@article{mbs:/content/journal/jgv/10.1099/0022-1317-75-7-1785, author = "Willcocks, M. M. and Brown, T. D. K. and Madeley, C. R. and Carter, M. J.", title = "The complete sequence of a human astrovirus", journal= "Journal of General Virology", year = "1994", volume = "75", number = "7", pages = "1785-1788", doi = "https://doi.org/10.1099/0022-1317-75-7-1785", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-75-7-1785", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "We have determined the complete genomic sequence of human astrovirus serotype 1 isolated in Newcastle upon Tyne. The genome is 6813 nucleotides long and contains three sequential open reading frames (ORFs). The two closest to the 5′ end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and RNA-dependent RNA polymerase. A nuclear addressing sequence is also located here. The 3′ ORF encodes the virion structural polypeptides as a polyprotein precursor. This genomic organization resembles that of the plant virus family Luteoviridae. Nucleotide sequence data described in this paper appear in the EMBL database under accession no. Z25771.", }