RT Journal Article SR Electronic(1) A1 Mabondzo, Aloïse A1 Boussin, François A1 Raoul, Hervé A1 Le Naour, Richard A1 Gras, Gabriel A1 Vaslin, Bruno A1 Bartholeyns, Jacques A1 Romet-Lemonne, Jean-Loup A1 Dormont, DominiqueYR 1994 T1 Antibody-dependent cellular cytotoxicity and neutralization of human immunodeficiency virus type 1 by high affinity cross-linking of gp41 to human macrophage Fc IgG receptor using bispecific antibody JF Journal of General Virology, VO 75 IS 6 SP 1451 OP 1456 DO https://doi.org/10.1099/0022-1317-75-6-1451 PB Microbiology Society, SN 1465-2099, AB Human monocytes/macrophages, which express Fc receptors for IgG are involved in human immunodeficiency virus type 1 (HIV-1) infection and pathogenesis. These receptors are known to mediate numerous immunological functions including cell-mediated killing and possibly targeting of HIV to the lysophagosome monocyte-derived macrophage (MDM) entry route for virus neutralization. To study both activities in HIV-1 infection, MDM FcγRI was specifically selected using bispecific antibody (Bs-Ab) containing whole human monoclonal antibody against gp41 and the Fab′ fragment of murine anti- FcγRI 22.2 antibody. Bs-Ab was found to mediate potent antibody-dependent cellular cytotoxicity and virus neutralization., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-75-6-1451