1887

Abstract

Human monocytes/macrophages, which express Fc receptors for IgG are involved in human immunodeficiency virus type 1 (HIV-1) infection and pathogenesis. These receptors are known to mediate numerous immunological functions including cell-mediated killing and possibly targeting of HIV to the lysophagosome monocyte-derived macrophage (MDM) entry route for virus neutralization. To study both activities in HIV-1 infection, MDM FcRI was specifically selected using bispecific antibody (Bs-Ab) containing whole human monoclonal antibody against gp41 and the Fab′ fragment of murine anti- FcRI 22.2 antibody. Bs-Ab was found to mediate potent antibody-dependent cellular cytotoxicity and virus neutralization.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-75-6-1451
1994-06-01
2022-01-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/75/6/JV0750061451.html?itemId=/content/journal/jgv/10.1099/0022-1317-75-6-1451&mimeType=html&fmt=ahah

References

  1. Anderson C. L., Guyre P. M., Whiten J. C., Ryan D. H., Looney R. J., Fanger M. W. 1986; Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes: antibody characterization and induction of superoxide production in a monocyte cell line. Journal of Biological Chemistry 137:12856–12864
    [Google Scholar]
  2. Andreesen R., Bross K. J., Osteholz J., Emmrich F. 1986; Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens. Blood 67:1257–1264
    [Google Scholar]
  3. Barré-Sinoussi F., Chermann J. C., Rey F., Nugeyre M. T., Chamaret S., Gruest J., Dauguet C., Axler-Blin C., Brun-Vesinet F., Rouzioux C., Rozenbaum W., Montagnier L. 1983; Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS). Science 220:868–870
    [Google Scholar]
  4. Bernard J., Reveil B., Najman I., Liautaud-Roger F., Fouchard M., Picard O., Cattan A., Mabondzo A., Laverne S., Gallo R. C., Zagury D. 1990; Discrimination between protective and enhancing HIV antibodies. AIDS 6:242–249
    [Google Scholar]
  5. Boussin F., Dormont D., Merrouche Y., Fleury H., Dubeaux D., Bequet D., Gouasguen J., Brunet P. 1987; Possible involvement of HIV in neuropsychiatric episode in patient seronegative for two (or more) years. Lancet ii:571–572
    [Google Scholar]
  6. Boyer V., Broly H., Souche S., Madaule P., Rossier J., Zagury D., Desgranges C. 1991; Characterization and large production of human monoclonal antibodies against the HIV-1 envelope. Clinical and Experimental Immunology 83:452–459
    [Google Scholar]
  7. Connor R. L., Dinces N., Howell A. L., Romet-Lemonne J. L., Pasquali J. L., Fanger M. W. 1991; Fc receptors for IgG (FcyRs) on human monocytes and macrophages are not infectivity receptors for human immunodeficiency virus type 1 (HIV-1): studies using bispecific antibodies to target HIV-1 to various myeloid cell surface molecules, including the FcyR. Proceedings of the National Academy of Sciences U.S.A.: 889593–9597
    [Google Scholar]
  8. Desgranges C., Boyer V., Souche S., Sprucher S., Burny A., Gallo R. C., Bernard J., Reveil B., Zagury D. 1988; Monoclonal antibodies to HIV in a non infected, immunized volunteer. Lancet i:935–936
    [Google Scholar]
  9. Eron J. J., Gorczyca P., Kaplan J. C., D’Aquila R. T. 1992; Susceptibility testing by polymerase chain reaction DNA quantitation: a method to measure drug resistance of human immunodeficiency virus type 1 isolates. Proceedings of the National Academy of Sciences U.S.A.: 893241–3255
    [Google Scholar]
  10. Figdor C. G., Leemans J. M. M., Bont W. S., Vries J. E. 1983; Theory and practice of centrifugal elutriation (CE). Factors influencing the separation of human blood cells. Cell Biophysics 5:105–108
    [Google Scholar]
  11. Folks T., Powell D., Lightfoote M., Koenig S., Fauci A. S., Benn S., Rabson A., Daugherty D., Gendelman H. E., Hoggan M. D., Venkatesan S., Martin M. 1986; Biological and biochemical characterization of cloned leu-3 cell surving infection with the acquired immune deficiency syndrome retrovirus. Journal of Experimental Medicine 164:280–290
    [Google Scholar]
  12. Gartner S., Markovits P., Markovitz D. M., Kaplan M. H., Gallo R. C., Popovic M. 1986; The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233:215–219
    [Google Scholar]
  13. Gras G., Mabondzo A., Rostocker J., Beyssen V., Marce D., Herve F., Parnet-Mathieu F., Courpotin C., Dormont D. 1993; Vertical transmission of HIV-1 and humoral response in infected mothers. 2nd International Conference on HIV in Children and MothersSeptember Edinburgh:
    [Google Scholar]
  14. Guyre P. M., Graziano F. R., Vance A. B., Morganelli P. M., Fanger M. W. 1989; Monoclonal antibodies that bind to distinct epitopes on Fcγ RI are able to trigger receptor function. Journal of Immunology 143:1650–1655
    [Google Scholar]
  15. Hirt B. 1967; Selective extraction of polyoma DNA from infected mouse cell cultures. Journal of Molecular Biology 26:365
    [Google Scholar]
  16. Homsy J., Meyer M., Tatano M., Clarkson S., Levy J. A. 1989; The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells. Science 244:1357–1360
    [Google Scholar]
  17. Juoault T., Chapuis F., Olivier R., Bahraoui E., Gluckman J. C. 1991; Infection of monocytic cells by HIV1: combined role of FcR and CD4. Research in Virology 142:183–188
    [Google Scholar]
  18. Laure F., Courgnaud V., Rouzioux C., Blanche C. S., Veber F., Burgard M., Jaconet C., Griscelli C., Brechot C. 1988; Detection of HIV-1 DNA in infants and children by means of the polymerase chain reaction. Lancet ii:538–541
    [Google Scholar]
  19. Ljunggreen K., Fenyo E. M., Biberfeld M., Jondal M. 1987; Detection of antibodies which mediate human immunodeficiency virus-specific cellular cytotoxicity (ADCC) in vitro . Journal of Immunological Methods 104:7–14
    [Google Scholar]
  20. Mabondzo A., Aussage P., Bartholeyns J., Lenaour R., Raoul H., Romet-Lemonne J. L., Dormont D. 1992; Bispecific antibody targeting of human immunodeficiency virus type 1 (HIV-1) glycoprotein 41 to human macrophages through the Fc IgG receptor I mediates neutralizing effects in HIV-1 infection. Journal of Infectious Diseases 166:93–99
    [Google Scholar]
  21. McElrath M. J., Pruet J. E., Cohn Z. A. 1989; Mononuclear phagocytes of blood marrow: comparative role as viral reservoirs in human immunodeficiency virus type 1 infection. Proceedings of the National Academy of Sciences U.S.A.: 86675–679
    [Google Scholar]
  22. Madaule P., Gairin J. E., Benichou S., Rossier J. 1991; A peptide library expressed in yeast reveals new major epitopes from human immunodeficiency virus type 1. FEMS Microbiology and Immunology 76:99–108
    [Google Scholar]
  23. Munis J. R., Kornbluth R. S., Guatelli J. C., Richman D. D. 1992; Ordered appearance of human immunodeficiency virus type 1 nucleic acids following high multiplicity infection of macrophages. Journal of General Virology 73:1899–1906
    [Google Scholar]
  24. Ou C. Y., Kwork S., Mitchell S. W., Mack D. H., Sninsky J. J., Krebbs J. W., Feorino P., Warfield D., Schochetman G. 1988; DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells. Science 239:295–297
    [Google Scholar]
  25. Rey M., Spire B., Dormont D., Barré-Sinoussi F., Montagnier L., Chermann J. C. 1984; Characterization of the RNA- dependent DNA polymerase of a new human T-lymphotropic retrovirus (lymphadenopathy-associated virus). Biochemical and Biophysical Research Communications 121:126–133
    [Google Scholar]
  26. Robert-Guroff M., Brown M., Gallo R. C. 1985; HTLV-III neutralizing antibodies in patients with AIDS and AIDS related complex. Nature; London: 31672–74
    [Google Scholar]
  27. Roy S., Waimberg A. M. 1988; Role of the mononuclear phagocytic system in the development of acquired immunodeficiency syndrome (AIDS). Journal of Leukocyte Biology 43:91–97
    [Google Scholar]
  28. Saag S. M., Hahn B. H., Gibbons J., Li Y., Parks E., Parks W. P., Show G. M. 1988; Extensive variation of human immunodeficiency virus type-1 in vivo . Nature; London: 334440–444
    [Google Scholar]
  29. Takeda A., Tuazon C. U., Ennis F. A. 1988; Antibody- enhancement infection by HIV-1 via Fc receptor-mediating entry. Science 242:580–583
    [Google Scholar]
  30. Weiss R. A., Clapham P., Weber J., Chiensong-Popov R., Dalgleish A., Carne A., Weller I., Tedder R. S. 1985; Neutralization of human T-lymphotropic virus type III sera of AIDS and AIDS-risk patients. Nature; London: 31669–72
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-75-6-1451
Loading
/content/journal/jgv/10.1099/0022-1317-75-6-1451
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error