1887

Abstract

Cells infected with vaccinia viruses expressing the equine infectious anaemia virus (EIAV) gene (VGag) or plus the 5′ encoding protease (VGag/PR) were evaluated with monoclonal antibody to a p26 capsid protein linear epitope (QEISKFLTD). Both recombinant viruses expressed Gag precursor protein (55K) whereas only VGag/PR expressed a detectable Gag-Pol fusion protein (82K) with a functional protease, shown by subviral particles containing processed p26. Horses inoculated with VGag/PR produced antibodies reactive with EIAV Gag proteins.

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1994-04-01
2022-11-30
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