1887

Abstract

The role of brain neurotransmitter transport processes in rabies virus infection of neurons was examined. The uptake and release of γ-amino--butyric acid (GABA) in rabies virus-infected embryonic rat cortical neurons was assayed using tritiated ligands. A 45% reduction of [H]GABA uptake was observed 3 days post-infection, when a maximum level of infectious particle release occurs. At this time, kinetic analysis revealed significant changes in , whereas no changes were found in values in comparison with the control values. K and veratridine-induced [H]GABA release was increased in infected cultures (98% and 35%, respectively) as compared with control values. The results obtained from rabies virus-infected cultures provide some preliminary evidence of the involvement of GABA in the pathogenesis of rabies.

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/content/journal/jgv/10.1099/0022-1317-75-3-623
1994-03-01
2019-11-19
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-75-3-623
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