1887

Abstract

Infection of cultured vertebrate cells by Sindbis virus, an alphavirus, results in a reduction in the overall rate of protein synthesis and in selective termination (shutoff) of host-specified protein synthesis. The shutoff of host protein synthesis by Sindbis virus has been temporally correlated with a decrease in intracellular K concentration (and an increase in intracellular Na concentration) which occurs as a consequence of virus-mediated inhibition of the plasma membrane-associated Na/K ATPase. Incubation of Sindbis virus-infected cells in medium containing an elevated concentration of K resulted in an increase in the intracellular concentration of K, an increase in the overall rate of protein synthesis, and in partial reversal of the virus-induced termination of cell-specified protein synthesis. These results suggest that the virus-induced decrease in intracellular K concentration is required for efficient shutoff of host protein synthesis by Sindbis virus.

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/content/journal/jgv/10.1099/0022-1317-75-2-411
1994-02-01
2019-11-21
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-75-2-411
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