RT Journal Article SR Electronic(1) A1 Peng, Gao A1 Hongo, Seiji A1 Muraki, Yasushi A1 Sugawara, Kanetsu A1 Nishimura, Hidekazu A1 Kitame, Fumio A1 Nakamura, KiyotoYR 1994 T1 Genetic reassortment of influenza C viruses in man JF Journal of General Virology, VO 75 IS 12 SP 3619 OP 3622 DO https://doi.org/10.1099/0022-1317-75-12-3619 PB Microbiology Society, SN 1465-2099, AB We reported previously that the antigenicity of the haemagglutinin-esterase (HE) glycoprotein of the human influenza C virus strain C/Nara/1/85 was indistinguishable from that of strain C/Nara/82. However, the ribonuclease T1-oligonucleotide map of total virion RNA of C/Nara/1/85 differed remarkably from the map of C/Nara/82, resembling instead the map of C/Nara/ 2/85, which has an HE antigenicity dissimilar to C/Nara/82 and C/Nara/1/85. This observation raised the possibility that C/Nara/1/85 might have arisen by reassortment from two viruses closely related to C/Nara/ 82 and C/Nara/2/85, respectively. Here, we compared the total nucleotide sequence of the HE gene and partial sequences of the other genes of C/Nara/1/85 with those of C/Nara/82 and C/Nara/2/85. The results suggest that C/Nara/1/85 has inherited HE and NP genes from a C/Nara/82-related virus and the PB2, PB1, PA, M and NS genes from a C/Nara/2/85-related virus., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-75-12-3619