@article{mbs:/content/journal/jgv/10.1099/0022-1317-75-11-3229, author = "Stevenson, David and Colman, Kathryn L. and Davison, Andrew J.", title = "Delineation of a Sequence Required for Nuclear Localization of the Protein Encoded by Varicella-zoster Virus Gene 61", journal= "Journal of General Virology", year = "1994", volume = "75", number = "11", pages = "3229-3233", doi = "https://doi.org/10.1099/0022-1317-75-11-3229", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-75-11-3229", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "All characterized alphaherpesviruses encode a protein whose N-terminal region contains a novel zinc-binding motif, the C3HC4 domain. Homology between the different proteins is in general limited to key residues in this domain. In order to identify a separate landmark site in the C3HC4 protein encoded by varicella-zoster virus gene 61, namely the region required for nuclear localization, we have analysed a range of mutants in transient expression and immunofluorescence experiments. A basic region (RGAKRR) at residues 387 to 392 was found to be required for nuclear localization, and residues 390 and 391 were critical.", }