1887

Abstract

We investigated the effects of pseudorabies virus (PRV), herpes simplex virus type 1 (HSV-1), and equine- herpesvirus type 1 (EHV-1) ICP4 homologues on feline immunodeficiency virus (FIV) long terminal repeat (LTR)-directed gene expression. This was done by using the transient expression chloramphenicol acetyltrans- ferase (CAT) assay in Crandell feline kidney (CRFK) and whole fetus 4 cells transfected with a chimeric FIV FTR-CAT reporter construct in combination with effector plasmids expressing the PRV, HSV-1 or EHV-1 ICP4 homologue. The experiments demonstrated that the ICP4 homologues could significantly inhibit FIV FTR-directed gene expression. Moreover, the ICP4 homologues also exhibited a marked inhibitory effect on FIV replication in CRFK cells cotransfected with an infectious molecular clone of FIV.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-75-10-2783
1994-10-01
2022-05-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/75/10/JV0750102783.html?itemId=/content/journal/jgv/10.1099/0022-1317-75-10-2783&mimeType=html&fmt=ahah

References

  1. Bacon L. D., Witter R. L., Fadly A. M. 1989; Augmentation of retrovirus-induced lymphoid leukosis by Marek’s disease herpesviruses in white leghorn chickens. Journal of Virology 63:504–512
    [Google Scholar]
  2. Colebunders R., Mann J. M., Francis H., Bila K., Izaley L., Ilwaja M., Kakonde N., Quinn T., Curran T., Piot A. 1988; Herpes zoster in African patients: a clinical predictor of human immunodeficiency virus infection. Journal of Infectious Diseases 157:314–318
    [Google Scholar]
  3. Evermann J. F., Derse D., Dorn P. L. 1991; Interactions between herpesviruses and retroviruses: implications in the initiation of disease. Microbial Pathogenesis 10:1–9
    [Google Scholar]
  4. Faber S. W., Wilcox K. W. 1986; Association of the herpes simplex virus regulatory protein ICP4 with specific nucleotide sequences in DNA. Nucleic Acids Research 14:6067–6083
    [Google Scholar]
  5. Fields B. N., Knipe D. M. 1991 Fundamental Virology pp. 839–949 New York: Raven Press;
    [Google Scholar]
  6. Gorman C. M., Moffat L. F., Howard B. H. 1982; Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Molecular and Cellular Biology 2:1044–1051
    [Google Scholar]
  7. Graham F. L., van der Eb A. J. 1973; A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456–467
    [Google Scholar]
  8. Holmberg S. D., Stuart J. A., Gerber A. R., Byers R. H., Lee F. K., O’Malley P. M., Nahmias A. J. 1988; Prior herpes simplex virus type 2 infection as a risk factor for HIV infection. Journal of the American Medical Association 259:1048–1050
    [Google Scholar]
  9. Ihara S., Feldman L., Watanabe S., Ben-Porat T. 1983; Characterization of the immediate-early functions of pseudorabies virus. Virology 131:437–454
    [Google Scholar]
  10. Jacobse-Geels H. E. L., Horzinek M. C. 1983; Expression of feline infectious peritonitis coronavirus antigens on the surface of feline macrophage-like cells. Journal of General Virology 64:1859–1866
    [Google Scholar]
  11. Kawaguchi Y., Miyazawa T., Horimoto T., Itagaki S., Fukasawa M., Takahashi E., Mikami T. 1991; Activation of feline immunodeficiency virus long terminal repeat by feline herpesvirus type 1. Virology 184:449–454
    [Google Scholar]
  12. Kawaguchi Y., Norimine J., Miyazawa T., Kai C., Mikami T. 1992; Sequences within the feline immunodeficiency virus long terminal repeat that regulate gene expression and respond to activation by feline herpesvirus type 1. Virology 190:465–468
    [Google Scholar]
  13. Kirisawa R., Ohmori H., Iwai H., Kawakami Y. 1993; The genomic diversity among equine herpesvirus-1 strains isolated in Japan. Archives of Virology 129:11–22
    [Google Scholar]
  14. Kiyomasu T., Miyazawa T., Furuya T., Shibata R., Sakai H., Sakuragi J.-I., Fukasawa M., Maki N., Hasegawa A., Mikami T., Adachi A. 1991; Identification of feline immunodeficiency virus rev gene activity. Journal of Virology 65:4539–4542
    [Google Scholar]
  15. Laurence J. 1990; Molecular interactions among herpesviruses and human immunodeficiency viruses. Journal of Infectious Diseases 162:338–346
    [Google Scholar]
  16. Macher A. M., Reichert C. M., Strauss S. E., Longo D. L., Parrillo J., Lane H. C., Fauci A. S., Rook A. H., Manischewitz J. F., Quinnan G. V. Jr 1983; Death in the AIDS patient. Role of cytomegalovirus. New England Journal of Medicine 309:1454
    [Google Scholar]
  17. Matsumura S., Ishida T., Washizu T., Tomoda I., Nagata S., Chiba J., Kurata T. 1993; Pathologic features of acquired immunodeficiency-like syndrome in cats experimentally infected with feline immunodeficiency virus. Journal of Veterinary Medical Science 55:387–394
    [Google Scholar]
  18. Mermod N., Williams T. J., Tjian R. 1988; Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro . Nature; London: 332557–561
    [Google Scholar]
  19. Miyazawa T., Mikami T. 1993; Biological nature of feline immunodeficiency virus. Journal of Veterinary Medical Science 55:519–526
    [Google Scholar]
  20. Neumann J. R., Morency C. A., Russian K. O. 1987; A novel rapid assay for chloramphenicol acetyltransferase gene expression. BioTechniques 5:444–447
    [Google Scholar]
  21. Norimine J., Miyazawa T., Kawaguchi Y., Niikura M., Kai C., Mikami T. 1992; Comparison of viral promoter activities in feline cell lines (CRFK and fcwf-4 cells). Journal of Veterinary Medical Science 54:189–191
    [Google Scholar]
  22. Ohta Y., Masuda T., Tsujimoto H., Ishikawa K., Kodama T., Morikawa S., Nakai M., Honjo S., Hayami M. 1988; Isolation of simian immunodeficiency virus from African green monkeys and seroepidemioiogic survey of the virus in various nonhuman primates. International Journal of Cancer 41:115–122
    [Google Scholar]
  23. Pedersen N. C., Ho E. W., Brown M. L., Yamamoto J. K. 1987; Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science 235:790–793
    [Google Scholar]
  24. Pei D., Shih C. 1990; Transcriptional activation and repression by cellular DNA-binding protein C/EBP. Journal of Virology 64:1517–1522
    [Google Scholar]
  25. Qurnn T. C., Piot P., Mccormick J., Feinsod F. M., Taelman H., Kapita B., Stevens W., Fauci A. S. 1987; Serologic and immunologic studies in patients with AIDS in North America and Africa. Journal of the American Medical Association 257:2617–2621
    [Google Scholar]
  26. Roizman B., Carmichael L. E., Deinhardt F., De The G., Nahmias A. J., Plowright W., Rapp F., Sheldrick P., Takahashi M., Wolf K. 1981; Herpesviridae: definition, provisional nomenclature and taxonomy. Intervirology 16:201–217
    [Google Scholar]
  27. Sakai H., Siomi H., Shida H., Shibata R., Kiyomasu T., Adachi A. 1990; Functional comparison of transactivation by human retrovirus rev and rex genes. Journal of Virology 64:5833–5839
    [Google Scholar]
  28. Shibata R., Miura T., Hayami M., Ogawa K., Sakai H., Kiyomasu T., Ishimoto A., Adachi A. 1990; Mutational analysis of the human immunodeficiency virus type 2 (HIV-2) genome in relation to HIV-1 and simian immunodeficiency virus SIVAGM . Journal of Virology 64:742–747
    [Google Scholar]
  29. Smiley J. R., Panning B., Smibert C. A. 1991; Regulation of cellular genes by HSV products. In Herpesvirus Transcription and its Regulation pp. 152–174 Wagner E. K. Edited by Boston: CRC Press;
    [Google Scholar]
  30. Smith R. H., Caughman G. B., O’Callaghan D. J. 1992; Characterization of the regulatory functions of the equine herpesvirus 1 immediate-early gene product. Journal of Virology 66:936–945
    [Google Scholar]
  31. Umene K. 1985; Variability of the region of the herpes simplex virus type 1 genome yielding defective DNA: SmaI fragment polymorphism. Intervirology 23:131–139
    [Google Scholar]
  32. Viček C., Kozmik Z., Paces V., Schirm S., Schwyzer M. 1990; Pseudorabies virus immediate-early gene overlaps with an oppositely oriented open reading frame: characterization of their promoter and enhancer regions. Virology 179:365–377
    [Google Scholar]
  33. Weiss R., Teich N., Varmus H., Coffin J. 1984; RNA Tumor Viruses. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  34. Wu C. L., Wilcox K. W. 1991; The conserved DNA-binding domains encoded by the herpes simplex virus type 1 ICP4, pseudorabies virus IE180, and varicella-zoster virus ORF62 genes recognize similar sites in the corresponding promoters. Journal of Virology 65:1149–1159
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-75-10-2783
Loading
/content/journal/jgv/10.1099/0022-1317-75-10-2783
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error