RT Journal Article SR Electronic(1) A1 Sample, Jeffery A1 Kieff, Elizabeth F. A1 Kieff, Elliott D.YR 1994 T1 Epstein-Barr virus types 1 and 2 have nearly identical LMP-1 transforming genes JF Journal of General Virology, VO 75 IS 10 SP 2741 OP 2746 DO https://doi.org/10.1099/0022-1317-75-10-2741 PB Microbiology Society, SN 1465-2099, AB Although variation in the gene encoding the Epstein- Barr virus (EBV) nuclear protein 2 accounts for much of the difference in the transforming activities of the two EBV strain types, divergence in the principal lymphocyte growth-altering gene, LMP-1, has not been previously evaluated. We have now determined the nucleotide sequence of the LMP-1 gene of a type 2 isolate of EBV, AG876. Surprisingly, the AG876 LMP-1 protein is 93 % identical to the prototype type 1 EBV strain B95–8, and this is well within the range of variability previously noted among type 1 EBV LMP-1 genes., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-75-10-2741