1887

Abstract

Although variation in the gene encoding the Epstein- Barr virus (EBV) nuclear protein 2 accounts for much of the difference in the transforming activities of the two EBV strain types, divergence in the principal lymphocyte growth-altering gene, LMP-1, has not been previously evaluated. We have now determined the nucleotide sequence of the LMP-1 gene of a type 2 isolate of EBV, AG876. Surprisingly, the AG876 LMP-1 protein is 93 % identical to the prototype type 1 EBV strain B95–8, and this is well within the range of variability previously noted among type 1 EBV LMP-1 genes.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-75-10-2741
1994-10-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/75/10/JV0750102741.html?itemId=/content/journal/jgv/10.1099/0022-1317-75-10-2741&mimeType=html&fmt=ahah

References

  1. Abdel-Hamid M., Chen J., Constantine N., Massoud M., Raab-Traub N. 1992; EBV strain variation: geographical distribution and relation to disease state. Virology 190:168–175
    [Google Scholar]
  2. Adldinger H., Delius H., Freese U., Clarke J., Bornkamm G. 1985; A putative transforming gene of the Jijoye virus differs from that of Epstein-Barr virus prototypes. Virology 141:221–234
    [Google Scholar]
  3. Arrand J., Young L., Tugwood J. 1989; Two families of sequences in the small RNA-encoding region of Epstein-Barr virus (EBV) types A and B. Journal of Virology 63:983–986
    [Google Scholar]
  4. Baer R., Bankier A. T., Biggin M. D., Deininger P. L., Farrell P. J., Gibson T. J., Hatfull G., Hudson G. S., Satchwell S. C., Sequin C., Tufnell P. S., Barrell B. G. 1984; DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature; London: 310207–211
    [Google Scholar]
  5. Baichwal V. R., Sugden B. 1988; Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus. Oncogene 2:461–467
    [Google Scholar]
  6. Bornkamm G., Delius H., Zimber U., Hudewentz J., Epstein M. 1980; Comparison of Epstein-Barr virus strains of different origin by analysis of the viral DNAs. Journal of Virology 35:603–618
    [Google Scholar]
  7. Busson P., Ganem G., Flores P., Mugneret F., Clausse B., Caillou B., Braham K., Wakasugi H., Lipinski M., Tursz T. 1988; Establishment and characterization of three transplantable EBV-containing nasopharyngeal carcinomas. International Journal of Cancer 42:599–606
    [Google Scholar]
  8. Chen M., Tsai C., Liang C., Shu C., Huang C., Sulitzeanu D., Liu S., Chang Y. 1992; Cloning and characterization of the latent membrane protein (LMP) of a specific Epstein-Barr virus variant derived from the nasopharyngeal carcinoma in the Taiwanese population. Oncogene 7:2131–2140
    [Google Scholar]
  9. Cohen J., Wang F., Mannick J., Kieff E. 1989; Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation. Proceedings of the National Academy of Sciences, U.S.A 86:9558–9562
    [Google Scholar]
  10. Dambaugh T., Hennessy K., Chamnankit L., Kieff E. 1984; U2 region of Epstein-Barr virus DNA may encode Epstein-Barr virus nuclear antigen 2. Proceedings of the National Academy of Sciences, U.S.A 81:7632–7636
    [Google Scholar]
  11. Epstein M., Achong B., Barr Y. 1964; Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet i:702–703
    [Google Scholar]
  12. Fennewald S., van Santen V., Kieff E. 1984; The nucleotide sequence of a messenger RNA transcribed in latent growth transforming virus infection indicates that it may encode a membrane protein. Journal of Virology 51:411–419
    [Google Scholar]
  13. Gilligan K., Sato H., Rajadurai P., Busson P., Young L., Rickinson A., Tursz T., Raab-Traub N. 1990; Novel transcription from the Epstein-Barr virus terminal EcoRI fragment, DIJhet, in a nasopharyngeal carcinoma. Journal of Virology 64:4948–4956
    [Google Scholar]
  14. Hatfull G., Banker A., Barrell B., Farrell P. 1988; Sequence analysis of Raji Epstein-Barr virus DNA. Virology 164:334–340
    [Google Scholar]
  15. Heller M., Dambaugh T., Kieff E. 1981; Epstein-Barr virus DNA. IX. Variation among viral DNAs from producer and nonproducer infected cells. Journal of Virology 38:632–648
    [Google Scholar]
  16. Henderson S., Rowe M., Gregory C., Croom-Carter D., Wang F., Kieff E., Rickinson A. 1991; Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 65:1107–1115
    [Google Scholar]
  17. Henle W., Diehl B., Kohn G., zur Hausen H., Henle G. 1967; Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells. Science 157:1064–1065
    [Google Scholar]
  18. Hu L.-F., Zabarovsky E. R., Chen F., Cao S.-L., Ernberg I., Klein G., Winberg G. 1991; Isolation and sequencing of the Epstein-Barr virus BNLF-1 gene (LMP1) from a Chinese nasopharyngeal carcinoma. Journal of General Virology 72:2399–2409
    [Google Scholar]
  19. Hu L.-F., Chen F., Zheng X., Ernberg I., Cao S. L., Christensson B., Klein G., Winberg G. 1993; Clonability and tumorigenicity of human epithelial cells expressing the EBV-encoded membrane protein LMP1. Oncogene 8:1575–1583
    [Google Scholar]
  20. Kaye K. M., Izumi K. M., Kieff E. 1993; Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proceedings of the National Academy of Sciences, U.S.A 90:9150–9154
    [Google Scholar]
  21. Kieff E., Liebowitz D. 1990; Epstein-Barr virus and its replication. In Virology, 2nd edn. pp. 1889–1920 Fields B. N., Knipe D. M. Edited by New York: Raven Press;
    [Google Scholar]
  22. Knecht H., Bachmann E., Brousset P., Sandvej K., Nadal D., Bachmann F., Odermatt B. F., Delsol G., Pallesen G. 1993; Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's disease and identical to those observed in nasopharyngeal carcinoma. Blood 82:2937–2942
    [Google Scholar]
  23. Miller G., Robinson J., Heston L., Lipman M. 1974; Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection, and interference. Proceedings of the National Academy of Sciences, U.S.A 71:4006–4010
    [Google Scholar]
  24. Miller W. E., Edwards R. H., Walling D. M., Raab-Traub N. 1994; Sequence variation in the Epstein-Barr virus latent mem-brane protein 1. Journal of General Virology 75:2729–2740
    [Google Scholar]
  25. Moorthy R. K., Thorley-Lawson D. A. 1993; Biochemical, genetic, and functional analyses of the phosphorylation sites on the Epstein-Barr virus-encoded oncogenic latent membrane protein LMP-1. Journal of Virology 67:2637–2645
    [Google Scholar]
  26. Mosier D. E., Gulizia R. J., Baird S. M., Wilson D. B. 1988; Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature; London: 335256–259
    [Google Scholar]
  27. Murray R., Wang D., Young L., Wang F., Rowe M., Kieff E., Rickinson A. B. 1988; Epstein-Barr virus specific cytotoxic T- cell recognition of transfectants expressing the virus-coded latent membrane protein LMP. Journal of Virology 62:3747–3755
    [Google Scholar]
  28. Murray R., Kurilla M., Brooks J., Thomas W., Rowe M., Kieff E., Rickinson A. 1992; Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies. Journal of Experimental Medicine 176:157–168
    [Google Scholar]
  29. Nonoyama M., Pagano J. 1973; Homology between Epstein-Barr virus DNA and viral DNA from Burkitt’s lymphoma and naso-pharyngeal carcinoma determined by DNA-DNA reassociation kinetics. Nature; London: 24244–47
    [Google Scholar]
  30. Pallesen G., Hamilton-Dutoit S. J., Rowe M., Young L. S. 1991; Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. Lancet 337:320–322
    [Google Scholar]
  31. Pizzo P. A., Magrath I. T., Chattopadhyay S. K., Biggar R. J., Gerber P. 1978; A new tumour-derived transforming strain of Epstein-Barr virus. Nature; London: 272629–631
    [Google Scholar]
  32. Pope J. H., Horne M. K., Scott W. 1968; Transformation of fetal human leukocytes in vitro by filtrates of a human leukemic cell line containing herpes-like virus. International Journal of Cancer 3:857–866
    [Google Scholar]
  33. Rickinson A., Young L., Rowe M. 1987; Influence of the Epstein-Barr virus nuclear antigen EBNA2 on the growth phenotype of virus-transformed B cells. Journal of Virology 61:1310–1317
    [Google Scholar]
  34. Rowe M., Young L., Cadwallader K., Petti L., Kieff E., Rickinson A. 1989; Distinction between Epstein-Barr virus type-A (EBNA-2A) and type-B (EBNA-2B) isolates extends to the EBNA-3 family of nuclear proteins. Journal of Virology 63:1031–1039
    [Google Scholar]
  35. Sample J., Young L., Martin B., Chatman T., Kieff E., Rickinson A., Kieff E. 1990; Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B and EBNA-3C genes. Journal of Virology 64:4084–4092
    [Google Scholar]
  36. Sculley T., Sculley D., Pope J., Bornkamm G., Lenoir G., Rickinson A. 1988; Epstein-Barr virus nuclear antigens 1 and 2 in Burkitt lymphoma cell lines containing either ‘A’- or ‘B’-type virus. Intervirology 29:77–85
    [Google Scholar]
  37. Sixbey J., Shirley P., Chesney P., Buntin D., Resnick L. 1989; Detection of a second widespread strain of Epstein-Barr virus. Lancet ii:761–765
    [Google Scholar]
  38. Staal S. P., Ambinder R., Beschorner W. E., Hayward G. S., Mann R. 1989; A survey of Epstein-Barr virus DNA in lymphoid tissue: frequent detection in Hodgkin’s disease. American Journal of Clinical Pathology 91:1–5
    [Google Scholar]
  39. Wang D., Liebowitz D., Kieff E. 1985; An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 43:831–840
    [Google Scholar]
  40. Wang D., Liebowitz D., Wang F., Gregory C., Rickinson A., Larson R., Springer T., Kieff E. 1988; Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity. Journal of Virology 62:4173–4184
    [Google Scholar]
  41. Wang F., Gregory C., Sample C., Murray R., Liebowitz D., Rowe M., Rickinson A., Kieff E. 1990; Epstein-Barr virus latent infection membrane and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA 2 and LMP cooperatively induce CD23. Journal of Virology 64:2309–2318
    [Google Scholar]
  42. Weiss L. M., Strickler J. G., Warnke R. A., Purtilo D. T., Sklar J. 1989; Epstein-Barr viral DNA in tissues of Hodgkin’s disease. American Journal of Clinical Pathology 129:86–91
    [Google Scholar]
  43. Young L. S., Yao Q. Y., Rooney C. M., Sculley T. B., Moss D. J., Rupani H., Laux G., Bornkamm G. W., Rickinson A. B. 1987; New type B isolates of Epstein-Barr virus from Burkitt’s lymphoma and from normal individuals in endemic areas. Journal of General Virology 68:2853–2862
    [Google Scholar]
  44. Young L. S., Dawson C. W., Clark D., Rupani H., Busson P., Tursz T., Johnson A., Rickinson A. B. 1988; Epstein-Barr virus gene expression in nasopharyngeal carcinoma. Journal of General Virology 69:1051–1065
    [Google Scholar]
  45. Young L., Alfieri C., Hennessy K., Evans H., O’Hara C., Anderson K. C., Ritz J., Shapiro R. S., Rickinson A., Kieff E., Cohen J. I. 1989; Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lympho-proliferative disease. New England Journal of Medicine 321:1080–1085
    [Google Scholar]
  46. Zimber U., Adldinger H., Lenoir G., Vuillaume M., Knebel-Doeberitz L., Desranges C., Wittman P., Freese U., Schneider U., Bornkamm G. 1986; Geographic prevalence of two Epstein-Barr virus types. Virology 154:56–66
    [Google Scholar]
  47. zur Hausen H., Schulte-Holthausen H., Klein G., Henle W., Henle G., Clifford P., Santesson L. 1970; EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature; London: 2281056–1058
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-75-10-2741
Loading
/content/journal/jgv/10.1099/0022-1317-75-10-2741
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error