1887

Abstract

Although variation in the gene encoding the Epstein- Barr virus (EBV) nuclear protein 2 accounts for much of the difference in the transforming activities of the two EBV strain types, divergence in the principal lymphocyte growth-altering gene, LMP-1, has not been previously evaluated. We have now determined the nucleotide sequence of the LMP-1 gene of a type 2 isolate of EBV, AG876. Surprisingly, the AG876 LMP-1 protein is 93 % identical to the prototype type 1 EBV strain B95–8, and this is well within the range of variability previously noted among type 1 EBV LMP-1 genes.

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1994-10-01
2022-09-24
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