%0 Journal Article %A Simon, James H. M. %A Schockmel, Gerard A. %A Illei, Peter %A James, William %T A rodent cell line permissive for entry and reverse transcription of human immunodeficiency virus type 1 has a pre-integration block to productive infection %D 1994 %J Journal of General Virology, %V 75 %N 10 %P 2615-2623 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-75-10-2615 %I Microbiology Society, %X Replication of human immunodeficiency virus type 1 (HIV-1) is restricted to CD4-expressing primate cells. This tropism may be due partly to the absence from nonprimate cells of a species-specific factor which has an accessory role to CD4 during virus penetration. In this study we describe a rat B lymphocyte cell line in which there is efficient CD4-dependent entry of HIV-1. However, this cell line has a block to productive infection of HIV-1 at a stage between reverse transcription and integration. Our results demonstrate that the putative accessory factor for HIV-1 penetration is not restricted to primate cells and that there is a novel, uncharacterized cell-virus interaction at a stage between penetration and integration. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-75-10-2615