Introduction. Numerous approaches have been taken in the quest to understand and combat infection with human immunodeficiency virus (HIV), which leads to the fatal acquired immunodeficiency syndrome (AIDS) (Fields, 1994). Although extensive investigations have been performed and have yielded much information about HIV expression and regulation , such approaches are limited since they cannot duplicate effects mediated by cell-cell interactions and cytokine release from the many diverse cell types present . It is becoming widely accepted that animal models are essential (1) to study the temporal cascade of pathogenesis induced by the virus, (2) to study the effects of individual viral components within the context of a dynamic and constantly developing immune system and (3) to evaluate vaccine strategies and screen antiviral agents. To date the most appropriate AIDS model in animals is the simian immunodeficiency virus (SIV) infection of macaques (Letvin & King, 1990).


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