1887

Abstract

Immunization of mice with a recombinant vaccinia virus expressing the human papillomavirus type 16 (HPV-16) E6 gene elicits specific antibody, proliferative and cytotoxic T lymphocyte responses. T and B cell epitopes were mapped by using synthetic peptides. This study provides the background to future investigation aimed at developing prophylactic and therapeutic vaccines against HPV-16 infection and cervical cancer.

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1994-01-01
2021-10-22
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References

  1. Behbebani A. M. 1983; The smallpox story. Microbiological Reviews 47:455
    [Google Scholar]
  2. Benton C., Shahi-Dullah H., Hunter J. A. A. 1992; HPV in the immunosuppressed. In Papilloma Virus Report 3 pp. 23–26 Leeds: Leeds University Press;
    [Google Scholar]
  3. Chen L., Thomas E. K., Hu S.-L., Hellstrom I. 1991; Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen. Proceedings of the National Academy of Sciences, U.S.A 88:110–114
    [Google Scholar]
  4. Chen L., Miruno M. T., Singhal M. C., Hu S.-L., Galloway D. A., Hellstrom I., Hellstrom K. E. 1992; Induction of cytotoxic T lymphocytes specific for syngeneic tumor expressing the E6 oncoprotein of human papillomavirus type 16. Journal of Immunology 148:2618–2627
    [Google Scholar]
  5. Coupar B. E. H., Andrew M. E., Boyle D. B. 1988; A general method for the construction of recombinant vaccinia viruses expressing multiple foreign genes. Gene 68:1–10
    [Google Scholar]
  6. Crook T., Tidy J. A., Vousden K. H. 1991; Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and transactivation. Cell 67:547–556
    [Google Scholar]
  7. Davison A. J., Moss B. 1989; Structure of vaccinia virus early promoters. Journal of Molecular Biology 210:749–769
    [Google Scholar]
  8. Falk K., Rotzschke O., Stevannovic S., Jung G., Rammensee H. G. 1991; Allele-specific motifs revealed by sequencing of selfpeptides eluted from MHC molecules. Nature; London: 351290–296
    [Google Scholar]
  9. Falkner F. G., Moss B. 1988; Escherichia coli gpt gene provides dominant selection for vaccinia virus open reading frame expression vectors. Journal of Virology 62:1849–1854
    [Google Scholar]
  10. Friedrich U., Scheidman K. H., Walter G. 1986; Induction and characterization of antisera against terminal and internal peptides of SV40 large T antigen. Immunology Letters 12:207–215
    [Google Scholar]
  11. Higgins G. D., Uzelin D. M., Phillips G. E., Mcevoy P., Marin R., Burrell C. J. 1992; Transcription patterns of human papillomavirus type 16 in genital intraephithelialneoplasia: evidence for promoter usage within the E7 open reading frame during epithelial differentiation. Journal of General Virology 73:2047–2057
    [Google Scholar]
  12. Kotwal G. J., Moss B. 1989; Vaccinia virus encodes two proteins that are structurally related to members of the plasma serine inhibitor superfamily. Journal of Virology 63:600–606
    [Google Scholar]
  13. Mackett M., Smith G. L., Moss B. 1982; Vaccinia virus: a selectable eukaryotic cloning and expression vector. Proceedings of the National Academy of Sciences, U.S.A 79:7415
    [Google Scholar]
  14. Mann V. M., De Lao S. L., Brenes M., Brinton L. A., Rawls J. A., Green M., Reeves M. C., Rawls W. E. 1990; Occurrence of IgA and IgG antibodies to selected peptides representing human papillomavirus type 16 among cervical cancer cases and controls. Cancer Research 50:7815–7819
    [Google Scholar]
  15. Meneguzzi G., Cerni C., Kieny M. P., Lathe R. 1991; Immunization against human papillomavirus type 16 tumor cells with recombinant vaccinia viruses expressing E6 and E7. Virology 181:61–69
    [Google Scholar]
  16. Pirisi L., Yasumoto S., Feller M., Doniger J., Dipaolo J. A. 1987; Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. Journal of Virology 61:1061–1066
    [Google Scholar]
  17. Rudensky A. Y., Preston-Hurburlt P., Hong S. C., Barlow A., Janeway C. A. 1992; Sequence analysis of paptides bound to MHC class II molecules. Nature; London: 353622–627
    [Google Scholar]
  18. Scheffner M., Werness B. A., Huibregtse J. M., Levine A. J., Howley P. M. 1990; The E6 oncoprotein encoded by human papillomavirus type 16 and 18 promotes the degradation of p53. Cell 63:1129–1136
    [Google Scholar]
  19. Schlegel R., Phelps W. C., Zhang Y. L., Barbosa M. 1988; Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma. EMBO Journal 1:3181–3187
    [Google Scholar]
  20. Seedorf K., Ottersdorf T., Krämmer G., Röwekamp W. 1987; Identification of early proteins of the human papilloma virus type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells. EMBO Journal 6:139–144
    [Google Scholar]
  21. Smith G. L., Howard S. T., Chan Y. S. 1989; Vaccinia virus encodes a family of genes with homology to the serine proteinase inhibitors. Journal of General Virology 70:2333–2343
    [Google Scholar]
  22. Stauss H. J., Davies H., Sadovnikova E., Chain B., Horowitz N., Sinclair C. 1992; Induction of cytotoxic T lymphocytes with peptides in vitro: identification of candidate T-cell epitopes in human papillomavirus. Proceedings of the National Academy of Sciences, U.S.A 89:7871–7875
    [Google Scholar]
  23. Storey A., Pim D., Murray A., Osborn K., Banks L., Crawford L. 1988; Comparison of the in vitro transforming activities of human papillomavirus types. EMBO Journal 7:1815–1820
    [Google Scholar]
  24. Taichman L. B., Laporta R. F. 1987; The expression of papillomaviruses in epithelial cells. In The Papovaviriclae 2 pp. 109–139 Salzman N., Howley P. M. Edited by New York: Plenum Press;
    [Google Scholar]
  25. Tainer J. A., Getzoff E. D., Paterson Y., Olson A. J., Lerner R. A. 1985; The atomic mobility component of protein antigenicity. Annual Review of Immunology 3:501–535
    [Google Scholar]
  26. Townsend A. R. M., Rothbard J., Gotch F. M., Barhadur G., Wraith D., Mcmichael A. 1986; The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44:959–968
    [Google Scholar]
  27. Zhou J., Crawford L., Mclean L., Sun X. Y., Stanley M., Almond N., Smith G. L. 1990; Increased antibody responses to human papillomavirus type 16 LI protein expressed by recombinant vaccinia virus lacking serine protease inhibitor genes. Journal of General Virology 71:2185–2190
    [Google Scholar]
  28. Zhou J., Mcindoe A., Davies H., Sun X. Y., Crawford L. 1991; The induction of cytotoxic T-lymphocyte precursor cells by recombinant vaccinia virus expressing human papillomavirus type 16 L1. Virology 181:203–210
    [Google Scholar]
  29. zur Hausen H., Schneider A. 1987; The role of papillomaviruses in anogenital cancer. In The Papovaviridae 2 pp. 245–263 Salzman N., Howley P. M. Edited by New York: Plenum Press;
    [Google Scholar]
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