The Epstein-Barr virus (EBV) is a human B lymphotropic herpesvirus carried in a persistent state by over 90% of the world's population. Primary infection occurs by the oral route, generally in early childhood, and is asymptomatic. When infection is delayed until adolescence or later, infectious mononucleosis results in approximately 50% of cases. Although it has been postulated that the oropharynx provides a reservoir where circulating B cells can be infected during transit through this anatomical site, evidence has been presented suggesting that EBV can also persist in the B cell (Gratama , 1988; Yao , 1989 ). Cellular immune mechanisms are believed to be of the greatest importance in the suppression of infected cell proliferation, and the balance between continual infection and suppression results in a life-long carrier state (reviewed by Rickinson, 1986).


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error