RT Journal Article SR Electronic(1) A1 Xiao, Shu-Yuan A1 Liang, Mifang A1 Schmaljohn, Connie SYR 1993 T1 Molecular and antigenic characterization of HV114, a hantavirus isolated from a patient with haemorrhagic fever with renal syndrome in China JF Journal of General Virology, VO 74 IS 8 SP 1657 OP 1659 DO https://doi.org/10.1099/0022-1317-74-8-1657 PB Microbiology Society, SN 1465-2099, AB The relationship of a Hantaan-like virus (HV114), isolated from a patient with haemorrhagic fever with renal syndrome in Hubei Province, People’s Republic of China, to other pathogenic hantaviruses was evaluated by cross-neutralization studies and nucleotide sequence analysis of the M genome segment. Plaque reduction neutralization assays indicated that HV114 is closely related to prototype Hantaan (HTN) virus, strain 76-118, which was originally isolated from an Apodemus field mouse in Korea. Comparison of the M genome segments of HTN 76-118 and HV114 revealed sequence identity of 84·7% and 95·4% for nucleotides and deduced amino acids, respectively. These data demonstrate that HV114 and 76-118 are two closely related but different isolates of HTN virus, establishing the scientific basis for testing and future use in China of a recombinant vaccine expressing the genome of HTN virus strain 76-118., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-8-1657