1887

Abstract

The relationship of a Hantaan-like virus (HV114), isolated from a patient with haemorrhagic fever with renal syndrome in Hubei Province, People’s Republic of China, to other pathogenic hantaviruses was evaluated by cross-neutralization studies and nucleotide sequence analysis of the M genome segment. Plaque reduction neutralization assays indicated that HV114 is closely related to prototype Hantaan (HTN) virus, strain 76-118, which was originally isolated from an field mouse in Korea. Comparison of the M genome segments of HTN 76-118 and HV114 revealed sequence identity of 84·7% and 95·4% for nucleotides and deduced amino acids, respectively. These data demonstrate that HV114 and 76-118 are two closely related but different isolates of HTN virus, establishing the scientific basis for testing and future use in China of a recombinant vaccine expressing the genome of HTN virus strain 76-118.

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/content/journal/jgv/10.1099/0022-1317-74-8-1657
1993-08-01
2024-03-28
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References

  1. Antic D, Lim BU, Kang CY. 1991; Molecular characterization of the M genomic segment of the Seoul 80-39 virus: nucleotide and amino acid sequence comparisons with other hantaviruses reveal the evolutionary pathway.. Virus Research 19:47–57
    [Google Scholar]
  2. Huggins JW, Hsiang CM, Cosgriff TM, Guan MY, Smith JI, Wu ZO, LeDuc JW, Zheng ZM, Meegan JM, Wang QN, Oland DD, Gui XE, Gibbs PH, Yuan GH, Zhang TM. 1991; Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome.. Journal of Infectious Diseases 164:1119–1127
    [Google Scholar]
  3. Lee HW, Ahn CN, Song JW, Baek LJ, Seo TJ, Park SC. 1990; Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans.. Archives of Virology 1:35–47
    [Google Scholar]
  4. Parrington MA, Lee PW, Kang CY. 1991; Molecular characterization of the Prospect Hill virus M RNA segment: a comparison with the M RNA segments of other hantaviruses.. Journal of General Virology 72:1845–1854
    [Google Scholar]
  5. Sanger F, Nicklen S, Coulson AR. 1977; DNA sequencing with chain-terminating inhibitors.. Proceedings of the National Academy of Sciences, U.S.A. 74:5463–5467
    [Google Scholar]
  6. Schmaljohn CS, Hasty SE, Dalrymple JM, LeDuc JW, Lee HW, von Bonsdorff CH, Brummer-Korvenkontio M, Vaheri A, Tsai TF, Regnery HL, Goldgaber D, Lee PW. 1985; Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome.. Science 227:1041–1044
    [Google Scholar]
  7. Schmaljohn CS, Schmaljohn AL, Dalrymple JM. 1987; Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order.. Virology 157:31–39
    [Google Scholar]
  8. Schmaljohn CS, Hasty SE, Dalrymple JM. 1992; Preparation of candidate vaccinia-vectored vaccines for haemorrhagic fever with renal syndrome.. Vaccine 10:10–13
    [Google Scholar]
  9. Song G. 1982; The etiological studies of epidemic hemorrhagic fever. I. Isolation and characterization of a virus strain using the Apodemus agrarius from the unendemic area.. Acta Academiae medicinae sinica 4:66–73
    [Google Scholar]
  10. Song G, Huang YC, Hang CS, Hao FY, Li DX, Zheng XL, Liu WM, Li SL, Huo ZW, Huei LJ, Zhang QF. 1992; Preliminary human trial of inactivated golden hamster kidney cell (GHKC) vaccine against haemorrhagic fever with renal syndrome (HFRS).. Vaccine 10:214–216
    [Google Scholar]
  11. Vapalahti O, Kallio-Kokko H, Salonen EM, Brummer-Korvenkontio M, Vaheri A. 1992; Cloning and sequencing of Puumala virus Sotkamo strain S and M segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein.. Journal of General Virology 73:829–838
    [Google Scholar]
  12. Xiao SY, Zhu BL, Zhang MY, Zhang TM, Zheng ZM, Hsiang CM. 1986; A sequential study of serum specific IgM antibody responses in EHF and their relationship to the severity of illness.. Chinese Journal of Immunology 2:218–221
    [Google Scholar]
  13. Xiao SY, Zhu BL, Zhang M, Zheng Z, Hsiang JM, Meegan SY, LeDuc JW, Huggins JW, Cosgriff TM, Smith JI. 1987; Effect of ribavirin on the specific humoral immune responses of patients with hemorrhagic fever with renal syndrome.. Chinese Journal of Virology 3:243–247
    [Google Scholar]
  14. Xiao SY, Yanagihara R, Godec MS, Eldadah ZA, Johnson BK, Gajdusek DC, Asher DM. 1991; Detection of hantavirus RNA in tissues of experimentally infected mice using reverse transcriptase-directed polymerase chain reaction.. Journal of Medical Virology 33:277–282
    [Google Scholar]
  15. Xiao SY, Chu YK, Knauert FK, Lofts R, Dalrymple JM, LeDuc JW. 1992; Comparison of hantavirus isolates using a genus-reactive primer pair polymerase chain reaction.. Journal of General Virology 73:567–573 corrigendum 1601
    [Google Scholar]
  16. Yang ZQ, Zhu BL, Zhang M, Hu Z, Xiao SY, Zhang T, Zheng Z, Xiang J, Huggins JW. 1988; Isolation and identification of EHFV from plasma and urine of patients of EHF in fever phase.. Acta Academiae medicinae Hubei 9:301–306
    [Google Scholar]
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