RT Journal Article SR Electronic(1) A1 Ikeda, Sator A1 Neyts, Joha A1 Matsuura, Motohir A1 Kiso, Makot A1 Hasegawa, Akir A1 Nishimura, Chiak A1 Clercq, Erik DYR 1993 T1 Protective activity of the lipid A analogue GLA-60 against murine cytomegalovirus infection in immunodeficient mice JF Journal of General Virology, VO 74 IS 7 SP 1399 OP 1403 DO https://doi.org/10.1099/0022-1317-74-7-1399 PB Microbiology Society, SN 1465-2099, AB The immunomodulating and murine cytomegalovirus (MCMV)-inhibiting effects of the synthetic lipid A subunit analogue GLA-60 were investigated in different strains of immunodeficient mice. Peritoneal natural killer (NK) cells obtained from nude (nu/nu) C57BL/6 mice or normal NMRI mice, which had been treated intraperitoneally with 10 µg of GLA-60 1 day earlier, exhibited a greater cytolytic activity than those from untreated mice. GLA-60 also stimulated NK cell activity in SCID (severe combined immune deficiency) mice (which are T and B cell-defective), but not in NK cell-defective beige (C57BL/6 bg/bg) mice. GLA-60 also enhanced the phagocytic activity of peritoneal macrophages in beige, nude and NMRI mice, but not in SCID mice. GLA-60, when administered as a single 150 µg dose 1 day before infection, completely protected beige mice against MCMV-associated mortality. It also caused a significant increase in the life-span of MCMV-infected nude and SCID mice., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-7-1399