%0 Journal Article %A Ikeda, Sator %A Neyts, Joha %A Matsuura, Motohir %A Kiso, Makot %A Hasegawa, Akir %A Nishimura, Chiak %A Clercq, Erik D %T Protective activity of the lipid A analogue GLA-60 against murine cytomegalovirus infection in immunodeficient mice %D 1993 %J Journal of General Virology, %V 74 %N 7 %P 1399-1403 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-74-7-1399 %I Microbiology Society, %X The immunomodulating and murine cytomegalovirus (MCMV)-inhibiting effects of the synthetic lipid A subunit analogue GLA-60 were investigated in different strains of immunodeficient mice. Peritoneal natural killer (NK) cells obtained from nude (nu/nu) C57BL/6 mice or normal NMRI mice, which had been treated intraperitoneally with 10 µg of GLA-60 1 day earlier, exhibited a greater cytolytic activity than those from untreated mice. GLA-60 also stimulated NK cell activity in SCID (severe combined immune deficiency) mice (which are T and B cell-defective), but not in NK cell-defective beige (C57BL/6 bg/bg) mice. GLA-60 also enhanced the phagocytic activity of peritoneal macrophages in beige, nude and NMRI mice, but not in SCID mice. GLA-60, when administered as a single 150 µg dose 1 day before infection, completely protected beige mice against MCMV-associated mortality. It also caused a significant increase in the life-span of MCMV-infected nude and SCID mice. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-7-1399