@article{mbs:/content/journal/jgv/10.1099/0022-1317-74-7-1399, author = "Ikeda, Sator and Neyts, Joha and Matsuura, Motohir and Kiso, Makot and Hasegawa, Akir and Nishimura, Chiak and Clercq, Erik D", title = "Protective activity of the lipid A analogue GLA-60 against murine cytomegalovirus infection in immunodeficient mice", journal= "Journal of General Virology", year = "1993", volume = "74", number = "7", pages = "1399-1403", doi = "https://doi.org/10.1099/0022-1317-74-7-1399", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-7-1399", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "The immunomodulating and murine cytomegalovirus (MCMV)-inhibiting effects of the synthetic lipid A subunit analogue GLA-60 were investigated in different strains of immunodeficient mice. Peritoneal natural killer (NK) cells obtained from nude (nu/nu) C57BL/6 mice or normal NMRI mice, which had been treated intraperitoneally with 10 µg of GLA-60 1 day earlier, exhibited a greater cytolytic activity than those from untreated mice. GLA-60 also stimulated NK cell activity in SCID (severe combined immune deficiency) mice (which are T and B cell-defective), but not in NK cell-defective beige (C57BL/6 bg/bg) mice. GLA-60 also enhanced the phagocytic activity of peritoneal macrophages in beige, nude and NMRI mice, but not in SCID mice. GLA-60, when administered as a single 150 µg dose 1 day before infection, completely protected beige mice against MCMV-associated mortality. It also caused a significant increase in the life-span of MCMV-infected nude and SCID mice.", }