1887

Abstract

Intragastric administration of live herpes simplex virus type 1 (HSV-1) was assessed for the induction of humoral immune responses and for protection against ocular and cutaneous challenge with virus. Mice showed no clinical abnormalities following intragastric inoculation with three different strains of virus (Miyama + GC, SC16, and PC, a thymidine kinase-defective mutant). Replication of virus was not detected in the oesophagus, superior cervical ganglia or coeliac ganglia of such animals and latent infection was not detected in these ganglia at later times after inoculation. Induction of a mucosal immune response was indicated by the presence of antibody (mainly IgG or IgA)-secreting cells in Peyerʹs patches. Intragastric immunization gave protection to some extent against ocular challenge and to a greater extent against cutaneous challenge with HSV-1. Following the latter challenge, particularly after intragastric immunization with strains SC16 and Miyama, the establishment of latency was almost completely prevented.

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1993-07-01
2021-10-21
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References

  1. Allansmith MR, Whitney CR. 1973; Immunoglobulins in the human eye. Archives of Ophthalmology 89:36–45
    [Google Scholar]
  2. Allansmith1 MR, Ebersole JL, Burna A. 1983; IgA antibody levels in human tears, saliva, and serum. Annals of the New York Academy of Sciences 409:766–768
    [Google Scholar]
  3. Blacklaws B, Krishna S, Nash A. Immunogenicity of herpes simplex virus type I glycoproteins expressed in vaccinia recombinants.. Virology 177:727–736
    [Google Scholar]
  4. Blyth W, Harbour D, Hill T. 1984; Pathogenesis of zosteriform spread of herpes simplex virus in the mouse.. Journal of General Virology 65:1477–1486
    [Google Scholar]
  5. Bowen JC, Alpar HO, Phillpots R, Brown MRW. 1992; Mucosal delivery of herpes simplex virus vaccine. Research in Virology 143:269–278
    [Google Scholar]
  6. Brandtzaeg P, Haltensen T, Kett K, Krajci P, Kvale D, Rognum TO, Scott H, Sollid LM. 1989; Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. . Gastroenterology 97:1562–1584
    [Google Scholar]
  7. Chen KS, Burlington DB, Quinnan GV, JR. 1987; Active synthesis of hemagglutinin-specific immunoglobulin A by lung cells of mice that were immunized intragastrically with inactivated influenza virus vaccine. Journal of Virology 61:2150–2154
    [Google Scholar]
  8. Cremer KJ, Mackett M, Wohlenberg C, Notkins AL, Moss L. 1985; Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice. . Science 228:737–740
    [Google Scholar]
  9. Eisenberg RJ, Cerini CP, Heilman CJ, Joseph AD, Dietzschold B, Golub E, Long D, Ponce de Leon M, Cohen GH. 1985; Synthetic glycoprotein D-related peptides protect mice against herpes simplex virus challenge.. Journal of Virology 56:1014–1017
    [Google Scholar]
  10. Erturk M, Hill TJ, Shimeld C, Jennings R. 1992; Acute and latent infection of mice immunized with HSV-1 ISCOM vaccine. Archives of Virology 125:87–101
    [Google Scholar]
  11. Ernst PB, Scicchitano R, Underdown B.J, Bienenstock J. 1988; Oral immunization and tolerance.. In Immunology of Gastrointestinal Tract and Liver pp. 125–144Edited by Heyworth MF, Jones AL. New York: Raven Press;
    [Google Scholar]
  12. Field H, Darby G. 1980; Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo.. Antimicrobial Agents and Chemotherapy 1 17:209–216
    [Google Scholar]
  13. Harbour DA, Hill TJ, Blyth WA. 1983; Recurrent herpes simplex in the mouse; inflammation in the skin and activation of the virus in the ganglia following peripheral stimulation. . Journal of General Virology 64:1491–1498
    [Google Scholar]
  14. Hill TJ, Blyth WA, Harbour D. 1975; Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease.. Journal of General Virology 28:341–353
    [Google Scholar]
  15. Hollander M, Wolfe DA. 1973 Non-parametric Statistical methods New York: John Wiley;
    [Google Scholar]
  16. Irie H, Harada Y, Kataoka M, Nagamuta M, Moriya Y, Handa M, Saito M, Matsubara S, Kojima K, Sugawara Y. 1992; Efficacy of oral administration of live herpes simplex virus type 1 as a vaccine.. Journal of Virology 66:2428–2434
    [Google Scholar]
  17. Jennings R, Quasim T, Sharrad R., Hockley D, Potter CW. 1988; Zwitterionic detergent solubilization of HSV-1 surface antigens.. Archives of Virology 98:137–153
    [Google Scholar]
  18. Johnson DC. 1991; Adenovirus vectors as potential vaccines against herpes simplex virus. . Reviews of Infectious Diseases 13: Supplement 11 912–916
    [Google Scholar]
  19. Liew FY, Russell SM, Appleyard G, Brand CM, Beale J. 1984; Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity. . European Journal of Immunology 14:350–356
    [Google Scholar]
  20. Long D, Madara TJ, Ponce de Leon M, Cohen GH, Montgomery PC, Eisenberg RJ. 1984; Glycoprotein D protects mice against lethal challenge with herpes simplex virus types 1 and 2.. Infection and Immunity 37:761–764
    [Google Scholar]
  21. McDermott MR, Bienenstock J. 1979; Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory and genital tissues. Journal of Immunology 122:1892–1898
    [Google Scholar]
  22. McDermott MR, Smiley JR, Lesile P, Brais J, Rudzroga HE, Bienenstock JR. 1984; Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2.. Journal of Virology 51:747–757
    [Google Scholar]
  23. Meignier B, Jourdier TM, Norrild B, Pereira L, Roizman B. 1987; Immunization of experimental animals with reconstituted glycoprotein mixtures of herpes simplex virus 1 and 2: protection against challenge with virulent virus.. Journal of Infectious Diseases 155:921–930
    [Google Scholar]
  24. Mertz GJ, Peterman G, Ashley R, Jourden JL, Salter D, Morrison L, McLean A. 1984; Herpes simplex virus type 2 glycoprotein subunit vaccine: tolerance and humoral and cellular responses in humans.. Journal of Infectious Diseases 150:242–249
    [Google Scholar]
  25. Mestecky J. 1987; The common mucosal immune system and current strategies for induction in external secretions. Journal of Clinical Immunology 7:265–276
    [Google Scholar]
  26. Mestecky J, McGhee JR, Arnold RR, Michalek SM, Prince SJ, Babb JL. 1978; Selective induction of an immune response in human external secretions by ingestion of bacterial antigen.. Journal of Clinical Investigation 61:731–737
    [Google Scholar]
  27. Montgomery P, Ayyildiz A. 1983; Induction and expression of antibodies in secretions: the ocular immune system.. Annals of the New York Academy of Sciences 409:424–439
    [Google Scholar]
  28. Nil S, Kamahora J. Studies on the growth of newly isolated herpes simplex virus in vivo.. Biken Journal 4:75–96
    [Google Scholar]
  29. Paoletti E, Lipinskas BR, Samsonoff C, Mercer S, Panacali D. Construction of live vaccines using genetically engineered poxviruses: biological activity of vaccinia virus recombinants expressing the hepatitis B surface antigen and the herpes simplex virus glycoprotein D.. Proceedings of the National Academy of Science. U.S.A. 81:193–197
    [Google Scholar]
  30. Peppard JV, Mann RV, Montgomery PC. 1991; Antibody production in rats following ocular topical or gastric intestinal immunization: kinetics of local and systemic antibody production. Current Eye Research 7:471–181
    [Google Scholar]
  31. Roizman B, Meignier B, Norrild B, Wagner JL. 1984; Bioengineering of herpes simplex virus variants of potential use as live vaccines. In Modern Approaches to Vaccines pp. 275–282Edited by Lerner RA, Chanock RM. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  32. Shimeld C, Hill TJ, Blyth WA, Easty D. 1990; Passive immunization protects the mouse eye from damage after herpes simplex virus infection by limiting spread of virus in the nervous system. . Journal of General Virology 71:681–687
    [Google Scholar]
  33. Sullivan DA, Allansmith MR. 1985; Hormonal influence on the secretory immune system of the eye: androgen modulation of IgA levels in tears of rats. Journal of Immunology 134:2978–2982
    [Google Scholar]
  34. Tullo AB, Shimeld C, Blyth WA, Hill TJ, Easty DL. 1983; Ocular infection with herpes simplex virus in nonimmune and immune mice. . Archives of Ophthalmology 101:961–964
    [Google Scholar]
  35. Wilson AD, Bailey M, Williams NA, Stokes CR. 1991; The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet haemocyanin using cholera toxin as an adjuvant. . European Journal of Immunology 21:2333–2339
    [Google Scholar]
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