RT Journal Article SR Electronic(1) A1 Malyshenko, S. I. A1 Kondakova, O. A. A1 Nazarova, Ju. V. A1 Kaplan, I. B. A1 Taliansky, M. E. A1 Atabekov, J. G.YR 1993 T1 Reduction of tobacco mosaic virus accumulation in transgenic plants producing non-functional viral transport proteins JF Journal of General Virology, VO 74 IS 6 SP 1149 OP 1156 DO https://doi.org/10.1099/0022-1317-74-6-1149 PB Microbiology Society, SN 1465-2099, AB Transgenic plants producing the 30K temperature-sensitive transport protein (TP) of tobacco mosaic virus (TMV) mutant Ni2519 (affecting cell-to-cell transport) were found to: (i) be susceptible to wild-type TMV U1 at 24 °C (a permissive temperature for Ni2519 TP), (ii) acquire a certain level of resistance to TMV U1 accumulation when maintained at 33 °C (a non-permissive temperature for Ni2519 TP) and (iii) lose the resistance to wild-type TMV after their transfer from 33 °C to 24 °C. It is suggested that reversible temperature-dependent conformational changes in Ni2519 TP are responsible for these phenomena and that production of a TP which is only partially functional in transgenic plants confers on these plants a resistance to the virus owing to reduction of the level of cell-to-cell transport. Transgenic tobacco plants producing the 32K TP of brome mosaic virus (BMV) acquired resistance to TMV U1 suggesting that BMV TP is partially functional in tobacco plants., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-6-1149