%0 Journal Article %A Malyshenko, S. I. %A Kondakova, O. A. %A Nazarova, Ju. V. %A Kaplan, I. B. %A Taliansky, M. E. %A Atabekov, J. G. %T Reduction of tobacco mosaic virus accumulation in transgenic plants producing non-functional viral transport proteins %D 1993 %J Journal of General Virology, %V 74 %N 6 %P 1149-1156 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-74-6-1149 %I Microbiology Society, %X Transgenic plants producing the 30K temperature-sensitive transport protein (TP) of tobacco mosaic virus (TMV) mutant Ni2519 (affecting cell-to-cell transport) were found to: (i) be susceptible to wild-type TMV U1 at 24 °C (a permissive temperature for Ni2519 TP), (ii) acquire a certain level of resistance to TMV U1 accumulation when maintained at 33 °C (a non-permissive temperature for Ni2519 TP) and (iii) lose the resistance to wild-type TMV after their transfer from 33 °C to 24 °C. It is suggested that reversible temperature-dependent conformational changes in Ni2519 TP are responsible for these phenomena and that production of a TP which is only partially functional in transgenic plants confers on these plants a resistance to the virus owing to reduction of the level of cell-to-cell transport. Transgenic tobacco plants producing the 32K TP of brome mosaic virus (BMV) acquired resistance to TMV U1 suggesting that BMV TP is partially functional in tobacco plants. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-6-1149