%0 Journal Article %A Gillespie, J. Stewar %A Cavanagh, Heather M. A. %A Behan, Wilhelmina M. H. %A Morrison, Lindsay J. A. %A McGarry, F. rance. %A Behan, Peter O. %T Increased transcription of interleukin-6 in the brains of mice with chronic enterovirus infection %D 1993 %J Journal of General Virology, %V 74 %N 4 %P 741-743 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-74-4-741 %I Microbiology Society, %X An animal model of chronic enteroviral infection was established by using PCR to detect viral genomes in animal tissues and to compare levels of transcription of a variety of cytokines in the brain. Chronic cocksackie-virus B1 infection was found in both brain and skeletal muscle of mice infected as neonates. The viral infection cleared by 240 days post-infection. Elevated levels of tumour necrosis factor α and interleukin-6 (IL-6) would appear to be linked to acute and chronic infection respectively. Levels of IL-6 return to normal upon clearance of the virus. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-4-741