1887

Abstract

A cDNA containing almost all of the hepatitis A virus (HAV) P3 sequences was expressed as a fusion protein with Protein A. A novel poly(U) polymerase activity was detected in the periplasmic space of cells transformed with this plasmid, and this activity showed many of the expected properties of a picornavirus 3D. A number of HAV-specific polypeptides were detected in these cells, and it is unclear which of these was responsible for the polymerase activity.

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1993-03-01
2021-10-19
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