1887

Abstract

The 5′ terminal cap structure of the mRNAs of human respiratory syncytial virus synthesized in the presence of -adenosyl--methionine consists of a 7-methyl guanosine linked to an unmethylated guanosine through a 5′-5′ pyrophosphate linkage formed by using the α and β phosphates of GTP. The complete cap structure is G (5′)ppp(5′)Gp… which is devoid of ribose 2′--methylation. Capping, including methylation, is coupled to transcription. These results constitute the first report of a pneumoviral mRNA cap structure.

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1993-03-01
2021-09-24
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