1887

Abstract

We studied the effect of two cytokines, basic fibroblastic growth factor (bFGF) and transforming growth factor beta (TGF-) on human cytomegalovirus (HCMV) replication in cultured human lung fibroblasts. We show that TGF- increases HCMV production, probably by a transcriptional mechanism, and that bFGF represses HCMV replication in a dose-dependent manner. These actions were antagonistic and the mechanisms involved were independent of the effects of these factors on cell DNA synthesis and proliferation.

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1993-02-01
2022-10-07
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