A monomeric, truncated form of the HA subunit of the haemagglutinin of fowl plague virus can be isolated from chorioallantoic membranes of infected eggs. This type of soluble HA seems to be generated by the elimination of the amino-terminal 19 amino acids from the native HA, including the disulphide linkage to the HA subunit. The same type of truncated HA could be isolated from a filtrate of the allantoic fluid of infected embryonated eggs. Antibodies prepared against this monomeric soluble form of HA did not inhibit haemagglutination or neutralize viral infectivity, but interfered with virus release and would be expected to impair the spread of virus after infection.


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