RT Journal Article SR Electronic(1) A1 Nakagomi, Osamu A1 Isegawa, Yuji A1 Hoshino, Yasutaka A1 Aboudy, Yair A1 Shif, Ilan A1 Silberstein, Ilana A1 Nakagomi, Toyoko A1 Ueda, Sigeharu A1 Sears, Johnna A1 Flores, JorgeYR 1993 T1 A new serotype of the outer capsid protein VP4 shared by an unusual human rotavirus strain Ro1845 and canine rotaviruses JF Journal of General Virology, VO 74 IS 12 SP 2771 OP 2774 DO https://doi.org/10.1099/0022-1317-74-12-2771 PB Microbiology Society, SN 1465-2099, AB The VP4 protein of human rotavirus (HRV) strain Ro1845 and canine rotavirus strains K9 and CU-1 exhibited greater than 98% amino acid identity within their group, but showed less identity with VP4 proteins of other HRV and animal rotavirus strains, the simian rotavirus strain RRV VP4 being most similar to them (90% amino acid identity). To exclude the possibility that these three strains were members of the RRV VP4 serotype P3, neutralization studies were performed using antisera to reassortant viruses containing the VP4 gene from each of Ro1845, CU-1 and RRV. The result established close antigenic similarity among the VP4 proteins of Ro1845, K9 and CU-1 and revealed only a marginal degree of similarity between the VP4 proteins of these three strains and that of strain RRV. These sequence and serological data suggest that the VP4 proteins of Ro1845, K9 and CU-1 represent a new P serotype which we propose to assign P13., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-12-2771