1887

Abstract

Resistance of mice to infection with herpes simplex virus type 2 (HSV-2) is strongly dependent on the function of macrophages (M). Infection of mouse M with HSV-2 results in an early (4 to 10 h) activation of the cells with an enhanced respiratory burst generated after membrane triggering with a phorbol ester. The role of monokines produced during this infection was analysed. Both interferon- (IFN-) and tumour necrosis factor- (TNF-) were produced within the very first hours after infection of M with HSV-2. Exogenously added IFN- conferred to M a respiratory burst capacity comparable to that seen after virus infection, whereas TNF- by itself was unable to prime M for a respiratory burst. In fact concentrations of TNF- comparable to those found in HSV-2-infected M cultures generally suppressed the response. However, when TNF- was added together with IFN-/ a dose-dependent synergistic enhancement of the IFN-induced M activation was seen. The kinetics of the synergistic activation by the two monokines was similar to that seen with IFN-/ alone. Neutralizing antibodies to IFN-/ and TNF- were able to diminish the HSV-induced priming of M for a respiratory burst. When the two antibodies were used together in subneutralizing concentrations an additional diminution of the responsiveness was seen, indicating that both monokines are involved in the virus-induced priming of M. However, high concentrations of antibodies to IFN-/ alone were able to abolish the activation completely, whereas this was not the case with anti-TNF-. Collectively these data demonstrate that autocrine secretion of IFN-/ by M infected with HSV-2 is a for the activation of M during the infection, and that this effect of IFN is synergistically enhanced, also in an autocrine manner, by TNF-. It is suggested that this reciprocal M-monokine interaction may be of importance in resistance to virus infections.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-74-10-2191
1993-10-01
2023-02-01
Loading full text...

Full text loading...

/deliver/fulltext/jgv/74/10/JV0740102191.html?itemId=/content/journal/jgv/10.1099/0022-1317-74-10-2191&mimeType=html&fmt=ahah

References

  1. Abramson J. S., Mills E. L., Giebink G. S., Quie P. G. 1982; Depression of monocyte and polymorphonuclear leukocyte oxidative metabolism and bactericidal capacity by influenza A virus. Infection and Immunity 35:350–355
    [Google Scholar]
  2. Arenzana-Seisdedos F., Mogensen S. C., Vuillier F., Fiers W., Virelizier J. L. 1988; Autocrine secretion of tumor necrosis factor under the influence of interferon-γ amplifies HLA-DR gene induction in human monocytes. Proceedings of the National Academy of Sciences, U. S. A. 85:6087–6091
    [Google Scholar]
  3. Balkwill F. R., Burke F. 1989; The cytokine network. Immunology Today 10:299–304
    [Google Scholar]
  4. Bancroft G. J., Sheehan K. C., Screiber R. D., Unanue E. R. 1989; Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in SCID mice. Journal of Immunology 143:127–130
    [Google Scholar]
  5. Bhaskaran G., Nii A., Sone S., Ogura T. 1992; Differential effects of interleukin-4 on superoxide anion production by human alveolar macrophages stimulated with lipopolysaccharide and interferon-y. Journal of Leukocyte Biology 52:218–223
    [Google Scholar]
  6. DeMaeyer E., DeMaeyer-Guignard J. 1983; Delayed hypersensitivity to Newcastle disease virus in high and low interferon-producing mice. Journal of Immunology 130:2392–2396
    [Google Scholar]
  7. Ding A. H., Nathan C. F. 1987; Trace levels of bacterial lipopolysaccharide prevent interferon-y or tumor necrosis factor-α from enhancing mouse peritoneal macrophage respiratory burst capacity. Journal of Immunology 139:1971–1977
    [Google Scholar]
  8. Ellermann-Eriksen S., Justesen J., Mogensen S. C. 1986a; Genetically determined difference in the antiviral action of α/β interferon in cells from mice resistant or susceptible to herpes simplex virus type 2. Journal of General Virology 67:1859–1866
    [Google Scholar]
  9. Ellermann-Eriksen S., Liberto M. C., Iannello D., Mogensen S. C. 1986b; X-linkage of the early in vitro α/β interferon response of mouse peritoneal macrophages to herpes simplex virus type 2. Journal of General Virology 67:1025–1033
    [Google Scholar]
  10. Ellermann-Eriksen S., Sommerlund M., Mogensen S. C. 1989; Differential sensitivity of macrophages from herpes simplex virus-resistant and -susceptible mice to respiratory burst priming by interferon-α/β. Journal of General Virology 70:2139–2147
    [Google Scholar]
  11. Faden H., Sutyla P., Ogra P. L. 1979; Effect of viruses on luminol-dependent chemiluminescence of human neutrophils. Infection and Immunity 24:673–678
    [Google Scholar]
  12. Ferrante A., Nandoskar M., Walz A., Goh D. H. B., Kowanko I. C. 1988; Effects of tumour necrosis factor alpha and interleukin-1 alpha and beta on human neutrophil migration, respiratory burst and degranulation. International Archives of Allergy and Applied Immunology 86:82–91
    [Google Scholar]
  13. Giridhar G., Hayakawa H., Kucera L. S., Myrvik Q. N. 1991; Priming of rabbit alveolar macrophages for enhanced oxidative responses by herpes simplex virus type 2 infection. Journal of Leukocyte Biology 49:442–448
    [Google Scholar]
  14. Haller O. (editor) 1981 Natural Resistance to Tumors and Viruses Berlin: Springer-Verlag;
    [Google Scholar]
  15. Huang T. T., Carlson E. J., Epstein L. B., Epstein C. J. 1992; The role of superoxide anions in the establishment of an interferon-a-mediated antiviral state. Free Radical Research Communications 17:59–72
    [Google Scholar]
  16. Ikeda T., Shimokata K., Daikoku T., Fukatsu T., Tsutsui Y., Nishiyama Y. 1992; Pathogenesis of cytomegalovirus-associated pneumonitis in ICR mice: possible involvement of superoxide radicals. Archives of Virology 127:11–24
    [Google Scholar]
  17. Ito M., O’Malley J. A. 1987; Antiviral effects of recombinant human tumor necrosis factor. Lymphokine Research 6:309–318
    [Google Scholar]
  18. Ito M., Karmali R., Krim M. 1985; Effect of interferon on chemiluminescence and hydroxyl radical production in murine macrophages stimulated by PMA. Immunology 56:533–541
    [Google Scholar]
  19. Jacobsen H., Mestan J., Mittnacht S., Dieffenbach C. W. 1989; Beta interferon subtype 1 induction by tumor necrosis factor. Molecular and Cellular Biology 9:3037–3042
    [Google Scholar]
  20. Jarstrand C., Einhorn S. 1981; Interferon enhances NBT-reduction and phagocytosis by human monocytes. Journal of Clinical and Laboratory Immunology 6:211–214
    [Google Scholar]
  21. Jones J. F. 1982; Interactions between human neutrophils and vaccinia virus: induction of oxidative metabolism and virus inactivation. Pediatric Research 16:525–529
    [Google Scholar]
  22. Kirchner H., Engler H., Schröder C. H., Zawatzky R., Storch E. 1983; Herpes simplex virus type 1-induced interferon production and activation of natural killer cells in mice. Journal of General Virology 64:437–441
    [Google Scholar]
  23. Kohase M., Henriksen-DeStefano D., May L. T., Vilcek J., Sehgal P. B. 1986; Induction of β2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell 45:659–666
    [Google Scholar]
  24. Lebon P. 1985; Inhibition of herpes simplex virus type 1-induced interferon synthesis by monoclonal antibodies against viral glycoprotein D and by lysosomotropic drugs. Journal of General Virology 66:2781–2786
    [Google Scholar]
  25. Mestan J., Digel W., Mittnacht S., Hillen H., Blohm D., Moller A., Jacobsen H., Kirchner H. 1986; Antiviral effects of recombinant tumour necrosis factor in vitro. Nature, London 323:816–819
    [Google Scholar]
  26. Mestan J., Brockhaus M., Kirchner H., Jacobsen H. 1988; Antiviral activity of tumour necrosis factor. Synergism with interferons and induction of oligo-2′, 5′-adenylate synthetase. Journal of General Virology 69:3113–3120
    [Google Scholar]
  27. Mogensen S. C. 1977; Genetics of macrophage-controled resistance to hepatitis induced by herpes simplex virus type 2 in mice. Infection and Immunity 17:268–273
    [Google Scholar]
  28. Mogensen S. C. 1979; Role of macrophages in natural resistance to virus infections. Microbiological Reviews 43:1–26
    [Google Scholar]
  29. Mogensen S. C., Virelizibr J. L. 1987; the interferon–macrophage alliance. In Interferon pp 55–84 Edited by Gresser I. London: Academic Press;
    [Google Scholar]
  30. Mogensen S. C., Teisner B., Andersen H. K. 1974; Focal necrotic hepatitis in mice as a biological marker for differentiation of Herpesvirus hominis type 1 and type 2. Journal of General Virology 25:151–155
    [Google Scholar]
  31. Mogensen S. C., Ellermann-Eriksen S., Sommerlund M. 1989; Herpes simplex virus type 2 primes mouse macrophages for an early and genetically determined respiratory burst mediated by interferon-α/β. Journal of General Virology 70:1371–1379
    [Google Scholar]
  32. Morahan P. S. 1984; Interactions of herpesviruses with mononuclear phagocytes. In Immunobiology of Herpes Simplex Virus Infection pp 71–90 Edited by Rouse B. T., Lopez C. Boca Raton: CRC Press;
    [Google Scholar]
  33. Müller S., Krasner J., Ozer H., Blumenson L. 1987; Modification of luminol-dependent chemiluminescence reactivity of peripheral blood leukocytes from patients with lymphoreticular tumor, solid cancer, or healthy blood donors by interferon-a. Journal of Interferon Research 7:1–15
    [Google Scholar]
  34. Oda T., Akaike T., Hamamoto T., Suzuki F., Hirano T., Maeda H. 1989; Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjungated SOD. Science 244:974–976
    [Google Scholar]
  35. Onozaki K., Urawa H., Tamatani T., Iwamura Y., Hashimoto T., Baba T., Suzuki H., Yamada M., Yamamoto S., Oppenheim J. J., Matsushima K. 1988; Synergistic interactions of interleukin 1, interferon-β, and tumor necrosis factor in terminally differentiating a mouse myeloid leukemic cell line (M1). Evidence that interferon-β is an autocrine differentiating factor. Journal of Immunology 140:112–119
    [Google Scholar]
  36. Orita K., Ando S., Kurimoto M. 1987; Synergism between human tumor necrosis factor and human interferon-a: effects on cells in culture. Acta medico Okayama 41:155–160
    [Google Scholar]
  37. Pedersen E. B., Haahr S., Mogensen S. C. 1983; X-linked resistance of mice to high doses of herpes simplex vims type 2 correlates with early interferon production. Infection and Immunity 42:740–746
    [Google Scholar]
  38. Rager-Zisman B., Kunkel M., Tanaka Y., Bloom B. R. 1982; Role of macrophage oxidative metabolism in resistance to vesicular stomatitis vims infection. Infection and Immunity 36:1229–1237
    [Google Scholar]
  39. Reis L. F. L., Lee T. H., Vilcek J. 1989; Tumor necrosis factor acts synergistically with autocrine interferon-β and increases interferon-β mRNA levels in human fibroblasts. Journal of Biological Chemistry 264:16351–16354
    [Google Scholar]
  40. Rinehart J. J., Gormus B. J., Lange P., Kaplan M. E. 1978; A new method for isolation of human monocytes. Journal of Immunological Methods 23:207–212
    [Google Scholar]
  41. Shparber M., Nathan C. 1986; Autocrine activation of macrophages by recombinant tumor necrosis factor but not recombinant interleukin-1. Blood 68: supplement 86a
    [Google Scholar]
  42. Thomson A. (editor) 1991 The Cytokine Handbook London: Academic Press;
    [Google Scholar]
  43. Trinchieri G., Kobayashi M., Rosen M., Loudon R., Murphy M., Perussia B. 1986; Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon. Journal of Experimental Medicine 164:1206–1225
    [Google Scholar]
  44. Wewers M. D., Rinehart J. J., She Z. W., Herzyk D. J., Hummel M. M., Kinney P. A., Davis W. B. 1990; Tumor necrosis factor infusions in humans prime neutrophils for hydrochlorous acid production. American Journal of Physiology 259:L276–1282
    [Google Scholar]
  45. Wong G. H. W., Goeddel D. V. 1986; Tumour necrosis factors a and β inhibit virus replication and synergize with interferons. Nature, London 323:819–822
    [Google Scholar]
  46. Zawatzky R., Kirchner H., DeMaeyer-Guignard J., De-Maeyer E. 1982; An X-linked locus influences the amount of circulating interferon induced in the mouse by herpes simplex virus type 1. Journal of General Virology 63:325–332
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-74-10-2191
Loading
/content/journal/jgv/10.1099/0022-1317-74-10-2191
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error