1887

Abstract

Summary

Recent results have revealed novel features in the process of antigenic diversification of FMDV. (i) Antigenic variation is not necessarily the result of immune selection. (ii) Single, critical amino acid replacements may either have a minor effect on antigenic specificity or cause a drastic antigenic change affecting many epitopes on an antigenic site. (iii) The effect of such a critical replacement may be suppressed by additional substitutions at neighbouring sites. (iv) Antigenic diversification does not necessarily involve net accumulation of amino acid substitutions over time. We review evidence that some of these features apply also to other riboviruses and retroviruses. A model is proposed to relate antigenic variation without immune selection to the quasispecies structure of RNA virus populations.

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1993-10-01
2024-06-18
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References

  1. Acharya R., Fry E., Stuart D., Fox G., Rowlands D., Brown F. 1989; The three-dimensional structure of foot-and-mouth disease virus at 2. 9 Ǻ resolution. Nature, London 337:709–715
    [Google Scholar]
  2. Baer G. M., Bellini W. J., Fishbein D. B. 1990; Rhabdoviruses. In Virology 2nd edn, pp 883–930 Edited by Fields B. N., Knipe D. M. New York: Raven Press;
    [Google Scholar]
  3. Bean W. J., Schell M., Katz J., Kawaoka Y., Naeve C., Gorman O., Webster R. G. 1992; Evolution of the H3 influenza virus hemagglutinin from human and nonhuman hosts. Journal of Virology 66:1129–1138
    [Google Scholar]
  4. Bbnmansour A., Brahimi M., Tuffereau C., Coulon P., Lafay F., Flamand A. 1992; Rapid sequence evolution of street rabies glycoprotein is related to the highly heterogeneous nature of the viral population. Virology 187:33–45
    [Google Scholar]
  5. Bolwell C., Brown A. L., Barnett P. V., Campbell R. O., Clarke B. E., Parry N. R., Ouldridge E. J., Brown F., Rowlands D. J. 1989; Host cell selection of antigenic variants of foot-and-mouth disease virus. Journal of General Virology 70:45–57
    [Google Scholar]
  6. Both G. W., Sleigh M. J., Cox N. J., Kendal A. P. 1983; Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites. Journal of Virology 48:52–60
    [Google Scholar]
  7. Boyer M., Novak Z., Fotedar A., Fraga E., Singh B. 1990; Critical role of an amino acid residue in a T cell determinant is due to its interaction with a neighbouring non-critical residue. European Journal of Immunology 20:2145–2148
    [Google Scholar]
  8. Burns D. P. W., Desrosiers R. C. 1991; Selection of genetic variants of simian immunodeficiency virus in persistently infected rhesus monkeys. Journal of Virology 65:1843–1854
    [Google Scholar]
  9. Carman W. F., Zanetti A. R., Karayiannis P., Waters J., Manzillo G., Tanzi If., Zuckerman A. J., Thomas H. C. 1990; Vaccine-induced escape mutant of hepatitis B virus. Lancet 336:325–329
    [Google Scholar]
  10. Carpenter S., Evans L. H., Sevoian M., Chesebro B. 1987; Role of the host immune response in selection of equine infectious anemia virus variants. Journal of Virology 61:3783–3789
    [Google Scholar]
  11. Carpenter S., Evans L. H., Sevoian M., Chesebro B. 1990; In vivo and in vitro selection of equine infectious anemia virus variants. In Applied Virology Research Virus Variability, Epidemiology and Control vol 2 pp 99–115 Edited by Kurstak E., Marusyk R. G., Murphy F. A., Van Regenmortel M. H. V. New York: Plenum Press;
    [Google Scholar]
  12. Carrillo C., Plana J., Mascarella R., Bergada J., Sobrino F. 1990; Genetic and phenotypic variability during replication of foot- and-mouth disease virus in swine. Virology 179:890–892
    [Google Scholar]
  13. Clements J. E., Gdovin S. I., Montelaro R. C., Narayan O. 1988; Antigenic variation in lentiviral diseases. Annual Review of Immunology 6:139–159
    [Google Scholar]
  14. Cromeans T., Fields H. A., Sobsey M. D. 1989; Replication kinetics and cytopathic effect of hepatitis A virus. Journal of General Virology 70:2051–2062
    [Google Scholar]
  15. Diez J., Mateu M. G., Domingo E. 1989; Selection of antigenic variants of foot-and-mouth disease virus in the absence of antibodies, as revealed by an in situ assay. Journal of General Virology 70:3281–3289
    [Google Scholar]
  16. Diez J., Davila M., Escarmis C., Mateu M. G., Dominguez J., Perez J. J., Giralt E., Melero J. A., Domingo E. 1990; Unique amino acid substitutions in the capsid proteins of foot-and-mouth disease virus from a persistent infection in cell culture. Journal of Virology 64:5519–5528
    [Google Scholar]
  17. Domingo E., Holland J.J. 1988; High error rates, population equilibrium and evolution of RNA replication systems. In RNA Genetics vol 3 Variability of RNA Genomes, pp 3–36 Edited by Domingo E., Holland J. J., Ahlquist P. Boca Raton: CRC Press;
    [Google Scholar]
  18. Domingo E., Holland J. J. 1993; Mutation rates and rapid evolution of RNA viruses. In Evolutionary Biology of Viruses. Edited by Morse S. S. New York: Raven Press; (in press)
    [Google Scholar]
  19. Domingo E., Sabo D., Taniguchi T., Weissmann C. 1978; Nucleotide sequence heterogeneity of an RNA phage population. Cell 13:735–744
    [Google Scholar]
  20. Domingo E., Martinez-Salas E., Sobrino F., De La Torre J. C., Portela A., Ortin J., Lopez-Galindez C., Perez-Brena P., Villanueva N., Najera R., Vandepol S., Steinhauer D., Depolo N., Holland J. J. 1985; The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance - a review. Gene 40:1–8
    [Google Scholar]
  21. Domingo E., Escarmis C., Martinez M. A., Martinez-Salas E., Mateu M. G. 1992; Foot-and-mouth disease virus populations are quasiespecies. Current Topics in Microbiology and Immunology 176:33–47
    [Google Scholar]
  22. Domingo E., Holland J. J., Biebricher C., Eigen M. 1993; Viral quasispecies: the concept and the word. In Molecular Evolution of Viruses Edited by Gibbs A., Calisher C. H., García-Arenal F. Cambridge: Cambridge University Press; (in press)
    [Google Scholar]
  23. Eigen M., Biebricher C. 1988; Sequence space and quasispecies distribution. In RNA Genetics. vol 3 Variability of RNA Genomes pp 211–245 Edited by Domingo E., Holland J. J., Ahlquist P. Boca Raton: CRC Press;
    [Google Scholar]
  24. Eigen M., Schuster P. 1979; The Hypercycle. A Principle of Natural Self-organization Berlin: Springer-Verlag;
    [Google Scholar]
  25. Fox G., Parry N. R., Barnett P. V., McGinn B., Rowlands D. J., Brown F. 1989; The cell attachment site on foot-and-mouth disease virus includes the amino acid sequence RGD (arginine-glycine-aspartic acid). Journal of General Virology 70:625–637
    [Google Scholar]
  26. Gebauer F., De La Torre J. C., Gomes I., Mateu M. G., Barahona H., Tiraboschi B., Bergmann I., Auge De Mello P., Domingo E. 1988; Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle. Journal of Virology 62:2041–2049
    [Google Scholar]
  27. Goudsmit J., Back N. K. T., Nara P. L. 1991; Genomic diversity and antigenic variation of HIV-1: links between pathogenesis, epidemiology and vaccine development. FASEB Journal 5:2427–2436
    [Google Scholar]
  28. Hampar B., Keehn M. A. 1967; Cumulative changes in the antigenic properties of herpes simplex virus from persistently infected cell cultures. Journal of Immunology 99:554–557
    [Google Scholar]
  29. Holland J. J., Spindler K., Horodyski F., Grabau E., Nichol S., Vandepol S. 1982; Rapid evolution of RNA genomes. Science 215:1577–1585
    [Google Scholar]
  30. Holland J. J., De La Torre J. C., Steinhauer D. A. 1992; RNA virus populations as quasispecies. Current Topics in Microbiology and Immunology 176:1–20
    [Google Scholar]
  31. Hovi T., Cantell K., Huovilainen A., Kinnunen E., Kunonen T., Lapinlbimu K., Poyry T., Roivaianen M., Salama N., Stenvik M., Silander A., Tholen C. J., Salminen S., Weckstrom P. 1986; Outbreak of paralytic poliomyelitis in Finland: widespread circulation of antigenically altered poliovirus type 3 in a vaccinated population. Lanceti i:1427–1432
    [Google Scholar]
  32. Kilbourne E. D., Taylor A. H., Whitaker C. W., Sahai R., Caton A. J. 1988; Hemagglutinin polymorphism as the basis for low- and high-yield phenotypes of swine influenza virus. Proceedings of the National Academy of Sciences, U,. S,. A 85:7782–7785
    [Google Scholar]
  33. Kono Y., Kobayashi K., Fukunaga Y. 1973; Antigenic drift of equine infectious anemia virus in chronically infected horses. Archiv fur die gesamte Virusforschung 41:1–10
    [Google Scholar]
  34. Lemon S. M., Murphy P. C., Schields P. A., Ping L. H., Feinstone S. M., Cromeans T., Jansen R. W. 1991; Antigenic and genetic variation in cytopathic hepatitis A virus variants arising during persistent infection: evidence for genetic recombination. Journal of Virology 65:2056–2065
    [Google Scholar]
  35. Lutley R., Pertursson G., Palsson P. A., Georgsson G., Klein J., Nathanson N. 1983; Antigenic drift in visna: virus variation during long term infection of Icelandic sheep. Journal of General Virology 64:1433–1440
    [Google Scholar]
  36. Martell M., Esteban J. I., Quer J., Genesca J., Weiner A., Esteban R., Guardia J., Gomez J. 1992; Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution. Journal of Virology 66:3225–3229
    [Google Scholar]
  37. Martinez M. A., Carrillo C., Gonzalez-Candelas F., Moya A., Domingo E., Sobrino F. 1991a; Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies. Journal of Virology 65:3954–3957
    [Google Scholar]
  38. Martinez M. A., Hernandez J., Piccone M. E., Palma E. L., Domingo E., Knowles N., Mateu M. G. 1991b; Two mechanisms of antigenic diversification of foot-and-mouth disease virus. Virology 184:695–706
    [Google Scholar]
  39. Martinez M. A., Dopazo J., Hernandez J., Mateu M. G., Sobrino F., Domingo E., Knowles N. J. 1992; Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades. Journal of Virology 66:3557–3565
    [Google Scholar]
  40. Mateu M. G., Martinez M. A., Rocha E., Andreu D., Parejo J., Giralt E., Sobrino F., Domingo E. 1989; Implications of a quasispecies genome structure: effect of frequent, naturally occuring amino acid substitutions on the antigenicity of foot-and-mouth disease virus. Proceeding of the National Academy of Sciences, U,. S,. A 86:5883–5887
    [Google Scholar]
  41. Mateu M. G., Martinez M. A., Capucci L., Andreu D., Giralt E., Sobrino F., Brocchi E., Domingo E. 1990; A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C. Journal of General Virology 71:629–637
    [Google Scholar]
  42. Mateu M. G., Andreu D., Carreno C., Roig X., Cairo J. J., Camarero J. A., Giralt E., Domingo E. 1992; Non-additive effects of multiple amino acid substitutions on antigen-antibody recognition. European Journal of Immunology 22:1385–1389
    [Google Scholar]
  43. Meyerhans A., Cheynier R., Albert J., Seth M., Kwok S., Sminsky J., Morfeldt-Manson L., Asjo B., Wain-Hobson S. 1989; Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations. Cell 58:901–910
    [Google Scholar]
  44. Minor P. D., John A., Ferguson M., Icenogle J. P. 1986; Antigenic and molecular evolution of the vaccine strain of type 3 poliovirus during the period of excretion by a primary vaccinee. Journal of General Virology 67:693–706
    [Google Scholar]
  45. Montelaro R. C., Parekh B., Preggo A., Issel C. J. 1984; Antigenic variation during persistent infection by equine infectious anemia virus, a retrovirus. Journal of Biological Chemistry 259:10539–10544
    [Google Scholar]
  46. Nishikawa K., Hanada N., Morishima T., Yoshida T., Hama-guchi M., Toyoda T., Nagai T. 1987; Antigenic characterization of the internal proteins of Newcastle disease virus by monoclonal antibodies. Virus Research 1:83–92
    [Google Scholar]
  47. Oxford J. S., Salum S., Corcoran T., Smith A. J., Grilli E. A., Schild G. C. 1986; An antigenic analysis using monoclonal antibodies of influenza A (H3N2) viruses isolated from an epidemic in a semi-closed community. Journal of General Virology 67:265–274
    [Google Scholar]
  48. Palese P., Young J. F. 1982; Variation of influenza A, B, and C viruses. Science 215:1468–1474
    [Google Scholar]
  49. Rocha E., Cox N. J., Black R. A., Harmon M. W., Harrison A. J., Kendal A. P. 1991; Antigenic and genetic variation in influenza A (H1N1) virus isolates recovered from a persistently infected immunodeficient child. Journal of Virology 65:2340–2350
    [Google Scholar]
  50. Rossmann M. G., Johnson J. E. 1989; Icosahedral RNA virus structure. Annual Review of Biochemistry 58:533–573
    [Google Scholar]
  51. Russell P. H., Samson A. C. R., Alexander D. J. 1990; Newcastle disease virus variations. In Applied Virology Research vol 2 Virus Variability, Epidemiology and Control pp 177–195 Edited by Kurstak E., Marusyk R. G., Murphy F. A., Van Regenmortel M. H. V. New York: Plenum Press;
    [Google Scholar]
  52. Rydbeck R., Love A., Orvell C., Norrby E. 1986; Antigenic variation of envelope and internal proteins of mumps virus strains detected with monoclonal antibodies. Journal of General Virology 67:281–287
    [Google Scholar]
  53. Sanchez-Palomino S., Rojas J. M., Martinez M. A., Fenyo E. M., Najera R., Domingo E., Lopez-Galindez C. 1993; Dilute passage promotes the expression of genetic and phenotypic variants of HIV-1 in cell culture. Journal of Virology 67:2938–2943
    [Google Scholar]
  54. Sato T. A., Fukuda A., Sugiura A. 1985; Characterization of major structural proteins of measles virus with monoclonal antibodies. Journal of General Virology 66:1397–1409
    [Google Scholar]
  55. Schild G. C., Oxford J. S., De Jong J. C., Webster R. G. 1983; Evidence for host-cell selection of influenza virus antigenic variants. Nature, London 303:706–709
    [Google Scholar]
  56. Scraba D. G. 1990; Functional aspects of the capsid structure of Mengo virus. Journal of Structural Biology 104:52–62
    [Google Scholar]
  57. Skehel J. J., Wiley D. C. 1988; Antigenic variation in influenza virus hemagglutinins. Variability of RNA Genomes In RNA Genetics vol 3 pp 139–146 Edited by Domingo E., Holland J. J., Ahlquist P. Boca Raton: CRC Press;
    [Google Scholar]
  58. Smith J. S. 1989; Rabies virus epitopic variation: use in ecologic studies. Advances in Virus Research 36:215–251
    [Google Scholar]
  59. Smith J. S., Reid-Sanden F. L., Roumillat L. F., Trimarchi C., Clark K., Baer G. M., Winkler W. G. 1986; Demonstration of antigenic variation among rabies vims isolates by using monoclonal antibodies to nucleo-capsid proteins. Journal of Clinical Microbiology 24:573–580
    [Google Scholar]
  60. Steinhauer D. A., De La Torre J. C., Meier E., Holland J. J. 1989; Extreme heterogeneity in populations of vesicular stomatitis virus. Journal of Virology 63:2072–2080
    [Google Scholar]
  61. Temin H. 1989; Is HIV unique or merely different?. Journal of Acquired Immune Deficiency Syndromes 2:1–9
    [Google Scholar]
  62. Thormar H., Barshatzky M. R., Arnesen K., Kozlowski P. B. 1983; The emergence of antigenic variation is a rare event in long term visna vims infection in vivo. Journal of General Virology 64:1427–1432
    [Google Scholar]
  63. van Vloten-Doting L., Bol J. F. 1988; Variability, mutant selection, and mutant stability in plant RNA viruses. In RNA Genetics vol 3 Variability of RNA Genomes, pp 37–51 Edited by Domingo E., Holland J. J., Ahlquist P. Boca Raton: CRC Press;
    [Google Scholar]
  64. Webster R. G., Laver W. G., Air G. M., Schild G. C. 1982; Molecular mechanisms of variation in influenza viruses. Nature, London 296:115–121
    [Google Scholar]
  65. Wiktor T. J., Koprowski H. 1978; Monoclonal antibodies against rabies virus produced by somatic cell hybridization: detection of antigenic variants. Proceedings of the National Academy of Sciences U,. S,. A 75:3938–3942
    [Google Scholar]
  66. Wolfs T. F., Zwart G., Barker M., Valk M., Kuiken C. L., Goudsmit J. 1991; Naturally occurring mutations within HIV-1 V3 genomic RNA lead to antigenic variation dependent on a single amino acid substitution. Virology 185:195–205
    [Google Scholar]
  67. Yewdell J. W., Gerhard W. 1981; Antigenic characterization of viruses by monoclonal antibodies. Annual Review of Microbiology 35:185–206
    [Google Scholar]
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