1887

Abstract

Six isolates of erythromelalgia-related poxvirus (ERPV) were characterized with respect to host range, c.p.e. and inclusions, pock formation on chorioallantoic membrane (CAM), morphogenesis, serological reactivity, pathogenesis in animals and DNA restriction fragment profile. The results suggest that ERPV is either a new member of the genus or a subspecies of ectromelia virus. Evidence is provided that (i) ERPV has a wide host range in which characteristic viral c.p.e. and inclusion bodies are induced; (ii) ERPV, unlike ectromelia virus, causes the formation of tiny greyish-white pocks on CAM both at 34 °C and 39 °C; (iii) eosinophilic A-type inclusions of ERPV do not contain viral particles; (iv) ERPV isolates are neutralized by both rabbit anti-vaccinia virus and mouse anti-ectromelia virus sera, but not vice versa; (v) young rabbits are not susceptible to ERPV by skin and/or corneal scratch infection even though ERPV is lethal for mice by intraperitoneal inoculation; (vi) the dIII and I fragment profiles of ERPV P-4 DNA are similar to, but obviously different from, those of Chinese ectromelia virus. These biological and pathogenic characteristics of ERPV are distinguishable from those of other members of the genus currently described in the literature.

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1992-08-01
2021-10-18
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References

  1. Andrewes C. H., Pereira H. G. 1972 Viruses of Vertebrates 3rd edn. pp. 373–414 Baltimore: Williams & Wilkins;
    [Google Scholar]
  2. Andrewes C. H., Pereira H. G., Wildy P. 1978 Viruses of Vertebrates 4th edn. pp. 356–389 London: Bailliere Tindall;
    [Google Scholar]
  3. Baxby D. 1982; The surface antigens of orthopoxviruses detected by cross-neutralization tests on cross-absorbed anti-sera. Journal of General Virology 58:251–262
    [Google Scholar]
  4. Baxby D. 1984; Poxviruses. In Textbook of Human Virology pp 929–950 Edited by Belshe R. B. Dittleton: MA PSG;
    [Google Scholar]
  5. Cai A. M., Zheng Z. M., Zhang J. H., Zhu W. P., Liu S. F. 1989; Preparation of high titres of immune sera to erythromelaigia-related poxvirus in rabbits. Wuhan Medical Journal (in Chinese) 13:73–74
    [Google Scholar]
  6. Doane F. W. 1986; Electron microscopy and immunoelectron microscopy. In Clinical Virology Manual pp. 71–88 Edited by Specter S., Lancz G. J. New York: Elsevier:
    [Google Scholar]
  7. Dumbell K. R. 1989; Poxviridae. In Andrewes’ Viruses of Vertebrates 5th edn. pp. 395–427 Edited by Porterfield J. S. London: Bailliere Tindall;
    [Google Scholar]
  8. Esposito J. J., Knight J. C. 1985; Orthopoxvirus DNA: a comparison of restriction profile and maps. Virology 143:230–251
    [Google Scholar]
  9. Esposito J. J., Obijeski J. F., Nakano J. H. 1978; Orthopoxvirus DNA: strain differentiation by electrophoresis of restriction endonuclease fragmented virion DNA. Virology 89:53–66
    [Google Scholar]
  10. Esposito J. J., Cabradilla C. D., Nakano J. H., Obijeski J. F. 1981; Intragenomic sequence transposition in monkeypox virus. Virology 109:231–243
    [Google Scholar]
  11. Fenner F., Witter R., Dumbell K. R. 1989 The Orthopoxviruses pp 1–28–269–302 San Diego: Academic Press;
    [Google Scholar]
  12. Gershon P. D., Black D. N. 1988; A comparison of the genomes of capripoxvirus isolates of sheep, goats and cattle. Virology 164:341–349
    [Google Scholar]
  13. Hsiung G. D. (editor) 1982 Diagnostic Virology p 22 New Haven: Yale University Press;
    [Google Scholar]
  14. Hubei Branch of the Chinese Medical Association 1988; Summary of the symposium on epidemic erythromelalgia. Clinical Journal of Internal Medicine (in Chinese) 5:43–45
    [Google Scholar]
  15. Ichihashi Y., Matsumoto S. 1966; Studies on the nature of Marchal bodies (A-type inclusion) during ectromelia virus infection. Virology 29:264–275
    [Google Scholar]
  16. Ichihashi Y., Matsumoto S. 1968; The relationship between poxvirus and A-type inclusion body during double infection. Virology 36:262–270
    [Google Scholar]
  17. Joklik W. K. 1962; The purification of four strains of poxvirus. Virology 18:9–18
    [Google Scholar]
  18. Mackett M., Archard L. C. 1979; Conservation and variation in Orthopoxvirus genome structure. Journal of General Virology 45:683–701
    [Google Scholar]
  19. Man Y. G., Chen M. H. 1989; Promotion effect of croton oil on the induction of cervical and vaginal cancers with herpes simplex virus types I and II in mice. Gynecological Oncology 33:27–33
    [Google Scholar]
  20. Müller H. K., Witter R., Schaffner W., Schumperli D., Menna A., Wyler R. 1978; Comparison of five poxvirus genomes by analysis with restriction endonucleases Hin dIII, Bam HI and Eco RI. Journal of General Virology 38:135–147
    [Google Scholar]
  21. Nakano J. H. 1986; Poxviruses. In Clinical Virology Manual pp. 417–435 Edited by Specter S., Lancz G. J. New York: Elsevier;
    [Google Scholar]
  22. Nakano J. H., Esposito J. J. 1989; Poxviruses. In Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections 6th edn pp 224–265 Edited by Schmidt N. J., Emmons R. W. Washington, D.C.: American Public Health Association;
    [Google Scholar]
  23. Patel D. D., Pickup D. J. 1987; Messenger RNAs of a strongly expressed late gene of cowpoxvirus contain 5′-terminal poly-A sequences. EMBO Journal 6:3787–3794
    [Google Scholar]
  24. Pickup D. J., Ink B. S., Hu W. S., Ray C. A., Joklik W. K. 1986; Hemorrhage in lesions caused by cowpoxvirus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. Proceedings of the National Academy of Sciences, U.S.A 83:7698–7702
    [Google Scholar]
  25. Rosen A., Pilaski J., Darai G. 1987; Genomic characterization of a poxvirus isolated from a child. Medical Microbiology and Immunology 176:181–188
    [Google Scholar]
  26. Rowson K. E. K., Rees T. A. L., Mahy B. W. J. 1981 A Dictionary of Virology; London: Blackwell:
  27. Sun W. C. 1964; Isolation and characterization of five ectromelia virus isolates in China. Newsletter of Bioproduct (in Chinese) 5:70–82
    [Google Scholar]
  28. Wu H. Y. 1986; Preliminary report of detecting virus antibodies in Chinese mice by an ELISA assay. Acta veterinariae zoologica sinica (in Chinese) 17:35–41
    [Google Scholar]
  29. Zhang J. H., Zheng Z. M., Zhu W. P., Cai A. M. 1990; Investigation and virus isolation of reappeared epidemic erythromelalgia in Wuhan. Wuhan Medical Journal (in Chinese) 14:41–42
    [Google Scholar]
  30. Zheng Z. M., Hsiung G. D. 1984; Complement-requiring neutralizing antibody in guinea-pigs with primary and recurrent genital herpes. Proceedings of the Society for Experimental Biology and Medicine 177:332–336
    [Google Scholar]
  31. Zheng Z. M., Mayo D. R., Hsiung G. D. 1983; Comparison of typing HSV-1 and HSV-2 isolates by biological, biochemical, immunological, and immunochemical techniques. Journal of Clinical Microbiology 17:396–399
    [Google Scholar]
  32. Zheng Z. M., Hu J. M., Liu S. F., Zhang J. H., Zhu W. P. 1987; Survey of epidemic erythromelalgia in Hanchuan and Puqi of Hubei province. Chinese Journal of Experimental and Clinical Virology (in Chinese) 1:34–39
    [Google Scholar]
  33. Zheng Z. M., Zhang J. H., Hu J. M., LIu S. F., Zhu W. P. 1988a; Poxviruses isolated from epidemic erythromelalgia in China. Lancet i:296
    [Google Scholar]
  34. Zheng Z. M., Zhang J. H., Hu J. M., LIu S. F., Zhu W. P., Cai A. M. 1988b; Poxvirus isolated from the throat swabs of patients with epidemic erythromelalgia. Chinese Journal of Experimental and Clinical Virology (in Chinese) 2:4–8
    [Google Scholar]
  35. Zheng Z. M., Zhang J. H., Zhu W. P., Cai A. M., LIu S. F., Liang H. L., Lei S. L., Fang P., Li L. 1988c; Some cellular ultrastructure changes and viral morphology observation in erythromelalgia-related poxvirus-infected cells. Chinese Journal of Experimental and Clinical Virology (in Chinese) 2:43–46
    [Google Scholar]
  36. Zheng Z. M., Specter S., Friedman H. 1991; Presence of specific IgG antibody to the A type inclusions of erythromelalgia-related poxvirus in the sera of patients with epidemic erythromelalgia. Archives of Dermatology Research 283:535–536
    [Google Scholar]
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