1887

Abstract

Transmission from four cases of bovine spongiform encephalopathy (BSE) to mice resulted in neurological disease in 100% of recipient animals, after incubation periods of between 265 and 700 days post-injection. The results from the four cases were very similar to one another. There were major differences in the incubation period between the four inbred strains of mice tested, and even between strains of the same genotype, and the incubation periods of heterozygote mice were much longer than those for any of the inbred strains. Transmission from a case of natural scrapie differed in two important respects: there were no differences in the incubation period between mouse strains of the same genotype, and that of the heterozygotes was between those of the homozygotic parental strains. The distribution of vacuolar degeneration in the brains of mice infected with scrapie also differed from those infected with the BSE isolates. Transmission was also achieved from formol-fixed BSE brain. These results show that the same strain of agent caused disease in the BSE cases, and that the relationship of BSE to scrapie in sheep is unclear.

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1992-08-01
2021-11-29
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References

  1. Barlow R. M., Middleton D. J. 1990; Dietary transmission of bovine spongiform encephalopathy to mice. Veterinary Record 126:111–112
    [Google Scholar]
  2. Brown P., Liberski P. P., Wolf A., Gajdusek D. C. 1990; Resistance of scrapie infectivity to steam autoclaving after formaldehyde fixation and limited survival after ashing at 360 °C; practical and theoretical implications. Journal of Infectious Diseases 161:467–472
    [Google Scholar]
  3. Bruce M. E., Dickinson A. G. 1979; Biological stability of different classes of scrapie agent. In Slow Transmissible Diseases of the Nervous System vol 2 pp. 71–86 Edited by Prusiner S. A., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
  4. Bruce M. E., Dickinson A. G. 1987; Biological evidence that the scrapie agent has an independent genome. Journal of General Virology 68:79–89
    [Google Scholar]
  5. Bruce M. E., Fraser H. 1982; Focal asymmetrical vacuolar lesions in the brains of mice infected with certain strains of scrapie. Acta neuropathologica 58:133–140
    [Google Scholar]
  6. Bruce M. E., Fraser H. 1991; Scrapie strain variation and its implications. Current Topics in Microbiology and Immunology 172:125–137
    [Google Scholar]
  7. Bruce M. E., Dickinson A. G., Fraser H. 1976; Cerebral amyloidosis in scrapie in the mouse: effect of agent and mouse genotype. Neuropathology and Applied Neurobiology 2:471–478
    [Google Scholar]
  8. Bruce M. E., Dickinson A. G., Fraser H. 1989; Mutation and asymmetrical vacuolation with a particular strain of scrapie. In Unconventional Virus Diseases of the Central Nervous System pp. 426–435 Edited by Court L. A., Brown P., Kingsbury D. T. La Melleray-de-Bretagne: Abbay de Melleray;
    [Google Scholar]
  9. Bruce M. E., McConnell I., Fraser H., Dickinson A. G. 1991; The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis. Journal of General Virology 72:595–603
    [Google Scholar]
  10. Carp R. I., Callahan S. M. 1991; Variation in the characteristics of 10 mouse-passaged scrapie lines derived from five scrapie-positive sheep. Journal of General Virology 72:293–298
    [Google Scholar]
  11. Dawson M., Wells G. A. H., Parker B. N. J. 1990; Preliminary evidence of the experimental transmissibility of bovine spongiform encephalopathy to cattle. Veterinary Record 126:112–113
    [Google Scholar]
  12. Dawson M., Wells G. A. H., Parker B. N. J., Scott A. C. 1991; Transmission studies of BSE in cattle, hamsters, pigs and domestic fowl. In Sub-acute Spongiform Encephalopathies pp. 25–32 Edited by Bradley R., Savey M., Marchant B. Commission of European Communities The Netherlands: Kluwer Academic;
    [Google Scholar]
  13. Dickinson A. G. 1976; Scrapie in sheep and goats. In Slow Virus Diseases in Animals and Man pp. 209–242 Edited by Kimberlin R. H. Amsterdam: North-Holland;
    [Google Scholar]
  14. Dickinson A. G., Meikle V. M. H. 1971; Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent. Molecular and General Genetics 112:73–79
    [Google Scholar]
  15. Dickinson A. G., Meikle V. M. H., Fraser H. 1968; Identification of a gene which controls the incubation period of some strains of scrapie in mice. Journal of Comparative Pathology 78:293–299
    [Google Scholar]
  16. Dickinson A. G., Meikle V. M. H., Fraser H. 1969; Genetical control of the concentration of ME7 scrapie agent in the brain of mice. Journal of Comparative Pathology 79:15–22
    [Google Scholar]
  17. Fraser H. 1976; The pathology of natural and experimental scrapie. In Slow Virus Diseases of Animals and Man pp. 267–305 Edited by Kimberlin R. H. Amsterdam: North-Holland;
    [Google Scholar]
  18. Fraser H. 1979; Neuropathology of scrapie: the precision of the lesions and their diversity. In Slow Transmissible Diseases of the Nervous System vol 1 pp. 387–406 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
  19. Fraser H. 1983; A survey of primary transmission of Icelandic scrapie (rida) to mice. In Virus Non-conventionnels et Affections du Systeme Nerveux Central pp. 34–46 Edited by Court L. A. Paris: Masson;
    [Google Scholar]
  20. Fraser H., Dickinson A. G. 1968; The sequential development of the brain lesions of scrapie in three strains of mice. Journal of Comparative Pathology 78:301–311
    [Google Scholar]
  21. Fraser H., Dickinson A. G. 1973; Scrapie in mice: agent strain differences in the distribution and intensity of grey matter vacuolation. Journal of Comparative Pathology 83:29–40
    [Google Scholar]
  22. Fraser H., McBride P. A. 1985; Parallels and contrasts between scrapie and dementia of the Alzheimer type: strategies and problems for experiments involving lifespan studies. In Senile Dementia of the Alzheimer Type pp. 250–268 Edited by Traber J., Gispen W. H. Berlin: Springer-Verlag;
    [Google Scholar]
  23. Fraser H., McConnell I., Wells G. A. H., Dawson M. 1988; Transmission of bovine spongiform encephalopathy to mice. Veterinary Record 123:472
    [Google Scholar]
  24. Fraser H., Bruce M. E., McBride P. A., Scott J. R. 1989; The molecular pathology of scrapie and the biological basis of lesion targeting. In Alzheimer’s Disease and Related Disorders pp. 637–644 Edited by Iqbal K., Wisniewski H. M., Winblad B. New York: Alan R. Liss:
    [Google Scholar]
  25. Fraser H., Bruce M. E., McConnell I. 1991; Murine scrapie strains, BSE models and genetics. In Sub-acute Spongiform Encephalopathies pp. 131–136 Edited by Bradley R., Savey M., Marchant B. Commission of European Communities The Netherlands: Kluwer Academic;
    [Google Scholar]
  26. Hartsough G. R., Burger D. 1965; Encephalopathy of mink. I. Epizootiologic and clinical observations. Journal of Infectious Diseases 115:387–392
    [Google Scholar]
  27. Jeffrey M., Wells G. A. H. 1988; Spongiform encephalopathy in a nyala (Tragelaphus angusi). Veterinary Pathology 25:398–399
    [Google Scholar]
  28. Jeffrey M., Scott J. R., Williams A., Fraser H. 1992; Ultrastructural features of bovine spongiform encephalopathy transmitted to mice from three bovine sources. Acta neuropathologica (in press)
    [Google Scholar]
  29. Kärber G. 1931; Beitrag zur kollectiven Behandlung pharmakolo-gische Reihenversuche. Archives of Experimental Pathology and Pharmacology 162:480–483
    [Google Scholar]
  30. Kimberlin R. H., Cole S., Walker C. A. 1987; Temporary and permanent modifications to a single strain of mouse scrapie on transmission to rats and hamsters. Journal of General Virology 68:1875–1881
    [Google Scholar]
  31. Kimberlin R. H., Walker C. A., Fraser H. 1989; The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice. Journal of General Virology 70:2017–2025
    [Google Scholar]
  32. Kirkwood J. K., Wells G. A. H., Wilesmith J. W., Cunningham A. A., Jackson S. I. 1990; Spongiform encephalopathy in an Arabian oryx (Oryx leucoryx) and a greater kudu (Tragelaphus strepsiceros). Veterinary Record 127:418
    [Google Scholar]
  33. Marsh R. F., Bessen R. A., Lehmann S., Hartsough G. R. 1991; Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy. Journal of General Virology 72:589–594
    [Google Scholar]
  34. Prusiner S. B., Westaway D. 1991; Infectious and genetic manifestations of prion diseases. Molecular and Plant Microbe Interactions 4:226–233
    [Google Scholar]
  35. Wells G. A. H., Scott A. C., Johnson C. T., Gunning R. F., Hancock R. D., Jeffrey M., Dawson M., Bradley R. 1987; A novel progressive spongiform encephalopathy in cattle. Veterinary Record 121:419–120
    [Google Scholar]
  36. Wilesmith J. W., Ryan J. B. M., Atkinson M. J. 1991; Bovine spongiform encephalopathy: epidemiological studies on the origin. Veterinary Record 128:199–203
    [Google Scholar]
  37. Williams E. S., Young S. 1980; Chronic wasting disease of captive mule deer; a spongiform encephalopathy. Journal of Wildlife Diseases 16:89–98
    [Google Scholar]
  38. Williams E. S., Young S. 1982; Spongiform encephalopathy of Rocky Mountain elk. Journal of Wildlife Diseases 18:465–471
    [Google Scholar]
  39. Wyatt J. M., Pearson G. R., Smerdon T. N., Gruffydd-Jones T. J., Wells G. A. H., Wilesmith J. W. 1991; Naturally occurring scrapie-like spongiform encephalopathy in five domestic cats. Veterinary Record 129:233–236
    [Google Scholar]
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