1887

Abstract

We examined the relationship between a measles virus isolate from a child with Kawasaki disease and two contemporaneous wild-type isolates from children with ‘classical’ measles and the Schwarz vaccine strain. Sequence analysis of 3118 bp from the nucleoprotein, matrix, fusion and haemagglutinin genes of each virus revealed that the isolate from the child with Kawasaki disease was not related to measles vaccine strains and did not contain any of the marked abnormalities previously found in subacute sclerosing panencephalitis isolates, but was more akin to wild-type isolates currently circulating in the U.K. A comparison of our sequences with those obtained from earlier wild-type U.K. isolates suggests significant evolution of measles virus in the U.K. over the last decade.

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1992-06-01
2022-08-10
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References

  1. Bellini W. J., Englund G., Richardson C. D., Rozenblatt S., Lazzarini R. A. 1986; Matrix genes of measles virus and canine distemper virus: cloning, nucleotide sequences and deduced amino acid sequences. Journal of Virology 58:408–416
    [Google Scholar]
  2. Buckland R., Gerald C., Barker R., Wild T. F. 1987; Fusion glycoprotein of measles virus: nucleotide sequence of the gene and comparison with other paramyxoviruses. Journal of General Virology 68:1695–1703
    [Google Scholar]
  3. Buckland R., Giraudon P., Wild T. F. 1989; Expression of measles virus nucleoprotein in Escherichia coli: use of deletion mutants to locate the antigenic sites. Journal of General Virology 70:435–441
    [Google Scholar]
  4. Burns J. C., Geha R. S., Schneeberger E. E., Newberger J. W., Rosen F. S., Glezen L. S., Huang A. S., Natale J., Leung D. Y. M. 1986; Polymerase activity in lymphocyte culture supernatants from patients with Kawasaki disease. Nature, London 323:814–816
    [Google Scholar]
  5. Cattaneo R., Schmid A., Eschle D., Baczko K., ter Meulen V., Billeter M. A. 1988; Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. Cell 55:255–265
    [Google Scholar]
  6. Cattaneo R., Schmid A., Spielhofer P., Kaelin K., Bazcko K., ter Meulen V., Pardovitz J., Flanagan S., Rima B. K., Udem S. A., Billeter M. A. 1989; Mutated and hypermutated genes of persistent measles virus which cause lethal human brain diseases. Virology 173:415–425
    [Google Scholar]
  7. Curran M. D., Rima B. K. 1988; Nucleotide sequence of the gene encoding the matrix protein of a recent measles virus isolate. Journal of General Virology 69:2407–2411
    [Google Scholar]
  8. Gerald C., Buckland R., Barker R., Freeman G., Wild T. F. 1986; Measles virus haemagglutinin gene: cloning, complete nucleotide sequence analysis and expression in COS cells. Journal of General Virology 67:2695–2703
    [Google Scholar]
  9. Giraudon P., Jacuier M. F., Wild T. F. 1988; Antigenic analysis of African measles virus field isolates: identification and localization of one conserved and two variable epitope sites on the NP protein. Virus Research 10:137–152
    [Google Scholar]
  10. Kawasaki T., Kosaki F., Okawa S., Shigematsu I., Yanagawa H. 1974; A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics 54:271–276
    [Google Scholar]
  11. Mäkelä M. J., Lund G. A., Salmi A. A. 1989a; Antigenicity of the measles virus haemagglutinin studied by using synthetic peptides. Journal of General Virology 70:603–614
    [Google Scholar]
  12. Mäkelä M. J., Salmi A. A., Norrby E., Wild T. F. 1989b; Monoclonal antibodies against measles virus react with synthetic peptides. Scandinavian Journal of Immunology 30:225–231
    [Google Scholar]
  13. Melish M. E., Marchette N. J. 1991; Kawasaki syndrome. In Textbook of Human Virology 2nd edn. pp 1021–1032 Edited by Belshe R. B. St Louis: Mosby Year Book;
    [Google Scholar]
  14. Melish M. E., Marchette N. J., Kaplan J. C., Kihara S., Ching D., Ho D. D. 1988; Absence of significant RNA-dependent DNA polymerase activity in lymphocytes from patients with Kawasaki syndrome. Nature, London 337:288–290
    [Google Scholar]
  15. Meyerhans A., Cheynier R., Albert J., Seth M., Kwok S., Sninsky J., Morfeldt-MAnson L., Åsjö B., Wain-Hobson S. 1989; Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential isolations. Cell 58:901–910
    [Google Scholar]
  16. Partidos C. D., Stanley C. M., Steward M. W. 1991; Immune responses in mice following immunization with chimeric synthetic peptides representing B and T cell epitopes of measles virus proteins. Journal of General Virology 72:1293–1299
    [Google Scholar]
  17. Rowley A. H., Gonzalez-Crussi F., Shulman S. T. 1988; Kawasaki syndrome. Reviews of Infectious Diseases 10:1–15
    [Google Scholar]
  18. Rozenblatt S., Eizenberg O., Ben-Levy R., La vie V., Bellini W. J. 1985; Sequence homology within the morbilliviruses. Journal of Virology 53:684–690
    [Google Scholar]
  19. Saiki R. K., Gelfand D. H., Stoffel S., Scharf S. J., Higuchi R., Horn G. T., Mullis K. B., Erlich H. A. 1988; Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491
    [Google Scholar]
  20. Shulman S., Rowley A. H. 1986; Does Kawasaki disease have a retroviral aetiology?. Lancet ii:545–546
    [Google Scholar]
  21. Taylor M. J., Godfrey E., Baczko K., ter Meulen V., Wild T. F., Rima B. K. 1991; Identification of several different lineages of measles virus. Journal of General Virology 72:83–88
    [Google Scholar]
  22. Tizard E. J., Suzuki A., Levin M., Dillon M. J. 1991; Clinical aspects of 100 patients with Kawasaki disease. Archives of Disease in Childhood 66185–188
    [Google Scholar]
  23. Vartanian J. P., Meyerhans A., Asjo B., Wain-Hobson S. 1991; Selection, recombination, and G to A hypermutation of human immunodeficiency virus type 1 genome. Journal of Virology 65:1779–1788
    [Google Scholar]
  24. Whitby D., Hoad J. G., Tizzard J., Dillon M., Weiss R. A., Schulz T. F. 1991; Isolation of measles virus from child with Kawasaki disease. Lancet 338:1215
    [Google Scholar]
  25. Winship P. R. 1989; An improved method for directly sequencing PCR amplified material using dimethyl sulphoxide. Nucleic Acids Research 171266
    [Google Scholar]
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