1887

Abstract

Chimpanzees infected with human immunodeficiency virus type 1 produce antibodies against the variable regions of the external envelope glycoprotein gp120. All five variable regions contain an epitope which is recognized by at least one of five chimpanzee sera. Each of the sera recognized a different pattern of epitopes. It is suggested that this varying response contributes to the emergence of variant viruses in the host. In contrast with the variability of the chimpanzees’ response to replicating virus, that of baboons to a candidate recombinant vaccine is more uniform. Baboons injected with recombinant gp120 produced high levels of antibodies to epitopes within both the variable and conserved regions which coincided with epitopes previously shown to induce neutralizing antibodies.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-73-5-1099
1992-05-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/73/5/JV0730051099.html?itemId=/content/journal/jgv/10.1099/0022-1317-73-5-1099&mimeType=html&fmt=ahah

References

  1. Albert J., Abrahamson B., Nagy K., Aurelius E., Gaines H., Nystrom G., Fenyo E. M. 1990; Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera. AIDS 4:107–112
    [Google Scholar]
  2. Balfe P., Simmonds P., Ludlam C. A., Bishop J. O., Leigh Brown A. J. 1990; Concurrent evolution of human immunodeficiency virus type 1 in patients infected from the same source: rate of sequence change and low frequency of inactivating mutations. Journal of Virology 64:6221–6233
    [Google Scholar]
  3. Berman P. W., Gregory T. J., Riddle L., Nakamura G. R., Champe M. A., Porter J. P., Wurm F. M., Hershberg R. D., Cobb E. K., Eichberg J. W. 1990; Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160. Nature, London 345:622–625
    [Google Scholar]
  4. Botarelli P., Houlden B. A., Haigwood N. L., Servis C., Montagns D., Abrignani S. 1991; N-glysosylation of HIV-gp120 may constrain recognition by T lymphocytes. Journal of Immunology 147:3128–3132
    [Google Scholar]
  5. Castro B. A., Walker C. M., Tateno M., Cheng-Mayer C., Heberling R., Eichberg J. W., Levy J. A. 1989; Human immunodeficiency virus (HIV) from experimentally infected chimpanzees: isolation and characterization. Journal of Medical Primatology 18:337–342
    [Google Scholar]
  6. Chahn T. L., Dreesman G. R., Kanda P., Linette G. P., Sparrow J. T., Ho D. H., Kennedy R. C. 1986; Induction of anti-HIV neutralizing antibodies by synthetic peptides. EMBO Journal 5:3065–3071
    [Google Scholar]
  7. Davis D., Chaudhri B., Stephens D. M., Carne C. A., Willers C., Lachmann P. J. 1990a; The immunodominance of epitopes within the transmembrane protein (gp41) of human immunodeficiency virus type 1 may be determined by the host’s previous exposure to similar epitopes on unrelated antigens. Journal of General Virology 71:1975–1983
    [Google Scholar]
  8. Davis D., Stephens D. M., Willers C., Lachmann P. J. 1990b; Glycosylation governs the binding of antipeptide antibodies to regions of hypervariable amino acid sequence within recombinant gp120 of human immunodeficiency virus type 1. Journal of General Virology 71:2889–2898
    [Google Scholar]
  9. Fung M., Sun C., Gordon W., Liou R., Daar E., Sun W., Chang N., Chang T. W., Ho D. 1991; An HIV-1 neutralizing monoclonal antibody recognizes an epitope in the V2 region of gp120. Abstracts of VII International Conference on AIDS, Florence vol 1: p 177
    [Google Scholar]
  10. Girard M., Kieny M. P., Pinter A., BarreSinoussi F., Nara P., Kolbe H., Kusumi K., Chaput A., Reinhart T., Muchmore E., Ronco J., Kacsorek M., Gomard E., Gluckman J. C., Fultz P. N. 1991; Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus. Proceedings of the National Academy of Sciences, U.S.A. 88:542–546
    [Google Scholar]
  11. Gnann J. W., Nelson J. A., Oldstone M. B. A. 1987; Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus. Journal of Virology 61:2639–2641
    [Google Scholar]
  12. Goudsmit J., Boucher C. A. B., Meloen R. H., Epstein L. G., Smit L., van der Hoek L., Bakker M. 1988; Human antibody response to a strain-specific HIV-1 gpl20 epitope associated with cell fusion inhibition. AIDS 2:157–164
    [Google Scholar]
  13. Hahn B. H., Shaw G. M., Taylor M. E., Redfield R. R., Markham P. D., Salahuddin S. Z., Wong-Staal F., Gallo R. C., Parks E. S., Parks W. P. 1986; Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS. Science 232:1548–1553
    [Google Scholar]
  14. Haigwood N. L., Nara P. L., Van Nest G., Scandella C. J., Eichberg J. W., Steimer K. S. 1991; Vaccination of primates with native recombinant HIV-1 gp120 generates broad spectrum neutralizing antibodies. In Vaccines’ 91 pp 51–58 Edited by Brown F., Chanock R. M., Ginsberg H., Lerner R. A. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  15. Ho D. H., Sarngadharan M. G., Hirsch M. S., Schooley R. T., Rota T. R., Kennedy R. C., Chanh T. C., Sato V. L. 1987; Human immunodeficiency virus neturalizing antibodies recognize several conserved domains on the envelope glycoproteins. Journal of Virology 61:2024–2028
    [Google Scholar]
  16. Ho D. H., Kaplan J. C., Rackauskas I. E., Gurney M. E. 1988; Second conserved domain of gp120 is important for HIV infectivity and antibody neutralization. Science 239:1021–1023
    [Google Scholar]
  17. Horal P., Svennerholm B., Jeansson S., Rymo L., Hall W. W., Vahlne A. 1991; Continuous epitopes of the human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein and reactivity of human sera to synthetic peptides representing various HIV-1 isolates. Journal of Virology 65:2718–2723
    [Google Scholar]
  18. Leonard C. K., Spellman M. W., Riddle L., Harris R. J., Thomas J. N., Gregory T. J. 1990; Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells. Journal of Biological Chemistry 265:10373–10382
    [Google Scholar]
  19. Mathiesen T., Broliden P. -A., Rosen J., Wahren B. 1989; Mapping of IgG subclass and T-cell epitopes on HIV proteins by synthetic peptides. Immunology 67:453–459
    [Google Scholar]
  20. Modrow S., Hahn B. H., Shaw G. M., Gallo R. C., Wong-Staal F., Wolf H. 1987; Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions. Journal of Virology 61:570–578
    [Google Scholar]
  21. Morrow W. J. W., Homsy J., Eichberg J. W., Krowka J., Pan L.-Z., Gaston I., Legg H., Lerche N., Thomas J., Levy J. A. 1989; Long-term observation of baboons, rhesus monkeys, and chimpanzees inoculated with HIV and given periodic immunosuppressive treatment. AIDS Research and Human Retroviruses 5:233–245
    [Google Scholar]
  22. Montefiori D. C., Zhou J., Barnes B., Lake D., Hersh E. M., Masuho Y., Lefkowitz L. B. 1991; Homotypic antibody responses to fresh clinical isolates of human immunodeficiency virus. Virology 182:635–643
    [Google Scholar]
  23. Nara P. L., Smit L., Dunlop N., Hatch W., Merges M., Waters D., Kelliher J., Gallo R. C., Fischinger P. J., Goudsmit J. 1990; Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees. Journal of Virology 64:3779–3791
    [Google Scholar]
  24. Neurath A. R., Strick N., Lee E. S. Y. 1990; B cell epitope mapping of human immunodeficiency virus envelope glycoproteins with long (19- to 36-residue) synthetic peptides. Journal of General Virology 71:85–95
    [Google Scholar]
  25. Palker T. J., Matthews T. J., Clark M. E., Cianciolo G. J., Randall R. R., Langlois A. F., White G. C., Safai B., Synderman R., Bolognesi D. P., Haynes B. F. 1987; A conserved region at the COOH terminus of human immunodeficiency virus gpl20 envelope protein contains an immunodominant epitope. Proceedings of the National Academy of Sciences, U.S.A. 84:2479–2483
    [Google Scholar]
  26. Ronco J., Charbit A., Dedieu J. F., Mancini M., Michel M. -L., Henin Y., O’Callaghan D., Kaczorek M., Girard M., Hofnung M. 1991; Is there a neutralization epitope in the second conserved domain of HIV-1 envelope protein. AIDS Research and Human Retroviruses 7:1–2
    [Google Scholar]
  27. Simmonds P., Balfe P., Ludlam C. A., Bishop J. O., Leigh Brown A. J. 1990; Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1. Journal of Virology 64:5840–5850
    [Google Scholar]
  28. Simmonds P., Zhang L. Q., McOmish F., Balfe P., Ludlam C. A., Leigh Brown A. J. 1991; Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo. Journal of Virology 65:6266–6276
    [Google Scholar]
  29. Stephens D. M., Davis D., Lachmann P. J. 1991; The second variable region of HIV-1 external envelope glycoprotein contains a neutralizing epitope. Abstracts of VII-International Conference on AIDS, Florence vol 2: p 72
    [Google Scholar]
  30. Tribbick G., Triantafyllou B., Lauricella R., Rodda S. J., Mason T. J., Geysen H. M. 1991; Systematic fractionation of serum antibodies using multiple antigen homologous peptides as affinity ligands. Journal of Immunological Methods 139:155–166
    [Google Scholar]
  31. Wain-Hobson S. 1989; HIV genome variability in vivo. AIDS 3: (supplement 1) S13–S18
    [Google Scholar]
  32. Warren R. Q., Wolf H., Shuler K. R., Eichberg J. W., Zajac R. A., Boswell R. N., Kanda P., Kennedy R. C. 1990; Synthetic peptides define the fine specificity of the human immunodeficiency virus (HIV) gp120 humoral immune response in HIV type-1 infected chimpanzees. Journal of Virology 64:486–492
    [Google Scholar]
  33. Willey R. L., Rutledge R. A., Dias S., Folks T., Theodore T., Buckler C. E., Martin M. A. 1986; Identification of conserved and divergent domains within the envelope gene of the acquired immunodeficiency syndrome retrovirus. Proceedings of the National Academy of Sciences, U.S.A. 83:5038–5042
    [Google Scholar]
  34. Wolfs T. F. W., Zwart G., Bakker M., Valk M., Kuiken C. L., Goudsmit J. 1991; Naturally occurring mutations within the HIV-1 V3 genomic RNA lead to antigenic variation dependent on a single amino acid substitution. Virology 185:195–205
    [Google Scholar]
  35. Zwart G., Langeduk H., Van Der Hoek L., de Jong J. -J., Wolfs T. F. W., Ramautarsing C., Bakker M., de Ronde A., Goudsmit J. 1991; Immunodominance and antigenic variation of the principal neutralization domain of HIV-1. Virology 181:481–489
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-73-5-1099
Loading
/content/journal/jgv/10.1099/0022-1317-73-5-1099
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error