1887

Abstract

The foot-and-mouth disease virus field isolate Burg-wedel/1987 subtype O was found to differ genetically from the antigenically related strain O Kaufbeuren within the region encoding the non-structural proteins. This genetic difference was indicated by the RNase mismatch cleavage method and confirmed by nucleotide sequencing. An alignment of sequences encoding proteinase 3C of the Burgwedel isolate and several other virus strains identified this isolate as an intertypic recombinant; the parent strains were O Kaufbeuren and a subtype C strain. Recombination occurred between nucleotide positions 5493 and 5521, within the region encoding peptide 3B. Thus, the 5′ three-quarters of the O genome were fused to the 3′-terminal quarter of the C genome. Other contemporary isolates from the same district are not recombinants. Sequence alignment distinguished four patterns of proteinase 3C-coding sequences among the virus strains analysed: subtypes A, C and O exhibit one pattern each, and another pattern is common to subtypes A, A and O.

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1992-03-01
2021-10-22
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References

  1. Berger H. G., Straub O. C., Ahl R., Tesar M., Marquardt O. 1990; Identification of foot-and-mouth disease virus replication in vaccinated cattle by antibodies to non-structural virus proteins. Vaccine 8:213–216
    [Google Scholar]
  2. Carroll A. R., Rowlands D. J., Clarke B. E. 1984; The complete nucleotide sequence of the RNA coding for the primary translation product of foot-and-mouth disease virus. Nucleic Acids Research 12:2461–2472
    [Google Scholar]
  3. Forss S., Strebel K., Beck E., Schaller H. 1984; Nucleotide sequence and genome organization of foot-and-mouth disease virus. Nucleic Acids Research 12:6587–6601
    [Google Scholar]
  4. Giraudo A. T., Sagedahl A., Bergmann I. E., La Torre J. L., Scodeller E. A. 1987; Isolation and characterization of recombinants between attenuated and virulent aphthovirus strains. Journal of Virology 61:419–425
    [Google Scholar]
  5. Grubman M. J., Zellner M., Wagner J. 1987; Antigenic comparison of the polypeptides of foot-and-mouth disease virus serotypes and other picomaviruses. Virology 158:133–140
    [Google Scholar]
  6. Harris T. J. R., Brown F., Sangar D. V. 1981; Differential precipitation of foot-and-mouth disease virus proteins made in vivo and in vitro by hyperimmune and virus particle guinea pig antisera. Virology 112:91–98
    [Google Scholar]
  7. King A. M. Q., McCahon D., Slade W. R., Newman J. W. I. 1982; Recombination in RNA. Cell 29:921–928
    [Google Scholar]
  8. King A. M. Q., McCahon D., Saunders K., Newman J. W. I., Slade W. R. 1985; Multiple sites of recombination within the RNA genome of foot-and-mouth disease virus. Virus Research 3:373–384
    [Google Scholar]
  9. Kirkegaard K., Baltimore D. 1986; The mechanism of RNA recombination in poliovirus. Cell 47:433–443
    [Google Scholar]
  10. Klump W., Marquardt O., Hofschneider P. H. 1984; Biologically active protease of foot-and-mouth disease virus is expressed from cloned viral cDNA in Escherichia coli . Proceedings of the National Academy of Sciences, U.S.A 81:3351–3355
    [Google Scholar]
  11. Knowles N. J., Marquardt O., Samuel A. R. 1988; Antigenic and molecular characterization of virus isolates from recent outbreaks of foot-and-mouth disease in the Federal Republic of Germany. Report to the Session of the Research Group of the Standing Technical Committee of the European Commission for the Control of Foot-and-Mouth Disease, Prague
    [Google Scholar]
  12. Krebs O., Berger H. G., Niedbalski W., Marquardt O. 1991a; Foot-and-mouth disease virus O1 Lombardy is biochemically related to O2 isolates. Virus Genes 5:255–265
    [Google Scholar]
  13. Krebs O., Berger H. G., Marquardt O. 1991b; The capsid protein-encoding region of foot-and-mouth disease virus O2 Brescia. Archives of Virology 120:135–143
    [Google Scholar]
  14. McCahon D., Slade W. R. 1981; A sensitive method for the detection and isolation of recombinants of foot-and-mouth disease virus. Journal of General Virology 53:333–342
    [Google Scholar]
  15. McCahon D., King A. M. Q., Roe D. S., Slade W. R., Newman J. W. I., Cleary A. M. 1985; Isolation and biochemical characterization of intertypic recombinants of foot-and-mouth disease virus. Virus Research 3:87–100
    [Google Scholar]
  16. Marquardt O., Adam K. H. 1988; Sequences of capsid protein VP1 of two type A foot-and-mouth disease viruses. Virus Genes 2:283–291
    [Google Scholar]
  17. Marquardt O., Adam K. H., Straub O. C. 1991; Detection and localization of single-base sequence differences in foot-and-mouth disease virus genomes by the RNase mismatch cleavage method. Journal of Virological Methods 33:267–282
    [Google Scholar]
  18. Martínez-Salas E., Ortίn J., Domingo E. 1985; Sequence of the replicase gene from foot-and-mouth disease virus C-l-Santa Pau (C-S8). Gene 35:55–61
    [Google Scholar]
  19. Parry N., Fox G., Rowlands D., Brown F., Fry E., Acharya R., Logan D., Stuart D. 1990; Structural and serological evidence for a novel mechanism of antigenic variation in foot-and- mouth disease virus. Nature, London 347:569–572
    [Google Scholar]
  20. Pringle C. R. 1965; Evidence of genetic recombination in foot-and- mouth disease virus. Virology 25:48–54
    [Google Scholar]
  21. Robertson B. H., Grubman M. J., Weddel G. N., Moore D. M., Welsh J. D., Fischer T., Dowbenko D. J., Yansura D. G., Small B., Kleid D. G. 1985; Nucleotide and amino acid sequence coding for polypeptides of foot-and-mouth disease virus type A 12. Journal of Virology 54:651–660
    [Google Scholar]
  22. Sangar D. V., Clark R. P., Rowlands D. J., Bittle J. L., Houghten R. A. 1986; The genome-linked proteins of aphthoviruses: specific immunoprecipitation of the three species detected on virus RNA and identification of possible precursors. Journal of General Virology 67:2405–2414
    [Google Scholar]
  23. Sanger F., Nicklen S., Coulson A. R. 1977; DNA sequencing with chain-terminating inhibitors. Proceedings of the National Academy of Sciences, U.S.A 74:5463–5467
    [Google Scholar]
  24. Smith D. B., Inglis S. C. 1987; The mutation rate and variability of eukaryotic viruses: an analytical review. Journal of General Virology 68:2729–2740
    [Google Scholar]
  25. Steinhauer D. A., Holland J. J. 1987; Rapid evolution of RNA viruses. Annual Review of Microbiology 41:409–433
    [Google Scholar]
  26. Vakharia V. N., Devaney M. A., Moore D. M., Dunn J. J., Grubman M. J. 1987; Proteolytic processing of foot-and-mouth disease virus polyproteins expressed in a cell-free system from clone-derived transcripts. Journal of Virology 61:3199–3207
    [Google Scholar]
  27. Wilson V., Taylor P., Desselberger U. 1988; Crossover regions in foot-and-mouth disease virus (FMDV) recombinants correspond to regions of high local secondary structure. Archives of Virology 102:131–139
    [Google Scholar]
  28. Wittmann G. 1964; Subtypen des Maulund Klauenseuchevirus vom Typ O. Ihre antigenen und immunologischen Eigenschaften und Beziehungen zueinander. Zentrallblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene A1–25
    [Google Scholar]
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