RT Journal Article SR Electronic(1) A1 Rixon, F. J. A1 Addison, C. A1 McLauchlan, J.YR 1992 T1 Assembly of enveloped tegument structures (L particles) can occur independently of virion maturation in herpes simplex virus type 1-infected cells JF Journal of General Virology, VO 73 IS 2 SP 277 OP 284 DO https://doi.org/10.1099/0022-1317-73-2-277 PB Microbiology Society, SN 1465-2099, AB Cells infected with a number of alphaherpesviruses produce non-infectious virion-related particles, termed L particles, in addition to infectious virions. L particles consist of the tegument and envelope components, but lack the virus capsid and DNA. Using a herpes simplex virus type 1 (HSV-1) temperature-sensitive mutant, ts1201, which fails to produce mature virions, we show that L particle production is independent of virion formation. Moreover, the quantity and protein composition of L particles generated by this mutant at the non-permissive temperature are indistinguishable from those produced in wild-type HSV-1 infections. Electron microscopy studies suggest that the processes governing the assembly of tegument and envelope components into L particles are similar to those involved in virion maturation., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-73-2-277