1887

Abstract

Primary cultures of normal human keratinocytes were inoculated with human papillomavirus type 1 (HPV-1), the agent responsible for deep plantar warts. Upon transfer to dead de-epidermized dermis and growth at the air-liquid interface, keratinocytes reconstituted a pseudoepidermis. Under these highly differentiating conditions, HPV-1 DNA amplification was found to take place in the reconstructed epidermis, being detectable from 7 days after the transfer and persisting for at least 10 days thereafter. The extent of keratinocyte differentiation may be insufficient to allow a complete HPV infectious cycle.

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/content/journal/jgv/10.1099/0022-1317-73-12-3269
1992-12-01
2019-11-23
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-73-12-3269
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