1887

Abstract

Two macaque monkeys were inoculated with a chimeric human and simian immunodeficiency virus carrying the and genes of human immunodeficiency virus type 1. Infectious virus was recovered from one of the monkeys at 2 and 6 weeks post-infection. The hybrid nature of the isolated viruses was verified by Southern and Western blotting analyses. Both of the monkeys infected with the chimera elicited a humoral antibody response against the virus.

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/content/journal/jgv/10.1099/0022-1317-73-11-2983
1992-11-01
2021-10-17
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References

  1. Adachi A., Gendelman H. E., Koenig S., Folks T., Willey R., Rabson A., Martin M. A. 1986; Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. Journal of Virology 59:284–291
    [Google Scholar]
  2. Alter H. J., Eichberg J. W., Masur H., Saxinger W. C., Gallo R., Macher A. M., Lane H. C., Fauci A. S. 1984; Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS. Science 226:549–552
    [Google Scholar]
  3. Clapham P. R., Weiss R. A., Dalgleish A. G., Exley M., Whitby D., Hogg N. 1987; Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: receptor modulation and differentiation induced by phorbol ester. Virology 158:44–51
    [Google Scholar]
  4. Desrosiers R. C., Ringler D. J. 1989; Use of simian immunodeficiency viruses for AIDS research. Intervirology 30:301–312
    [Google Scholar]
  5. Dewhurst S., Embretson J. E., Anderson D. C., Mullins J. I., Fultz P. N. 1990; Sequence analysis and acute pathogenicity of molecularly cloned SIVSMM–PBjl4. Nature, London 345:636–640
    [Google Scholar]
  6. Filice G., Cereda P. M., Varnier O. E. 1988; Infection of rabbits with human immunodeficiency virus. Nature, London 335:366–369
    [Google Scholar]
  7. Folks T., Benn S., Rabson A., Theodore T., Hoggan M. D., Martin M., Lightfoote M., Sell K. 1985; Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immune deficiency syndrome (AIDS)-associated retrovirus. Proceedings of the National Academy of Sciences, U.S.A. 82:4539–4543
    [Google Scholar]
  8. Fultz P. N., McClure H. M., Swenson R. B., McGrath C. R., Brodie A., Getchell J. P., Jensen F. C., Anderson D. C., Broderson J. R., Francis D. P. 1986; Persistent infection of chimpanzees with human T-lymphotropic virus type III/lymphadenopathy-associated virus: a potential model for acquired immunodeficiency syndrome. Journal of Virology 58:116–124
    [Google Scholar]
  9. Gajdusek D. C., Amyx H. L., Gibbs C. J. Jr, Asher D. M., Rodgers-Johnson P., Epstein L. G., Sarin P. S., Gallo R. C., Maluish A., Arthur L. O., Montagnier L., Mildvan D. 1985; Infection of chimpanzees by human T-lymphotropic retroviruses in brain and other tissues from AIDS patients. Lancet i:55–56
    [Google Scholar]
  10. Hirt B. 1967; Selective extraction of polyoma DNA from infected mouse cell cultures. Journal of Molecular Biology 26:365–369
    [Google Scholar]
  11. Kestler H., Kodama T., Ringler D., Marthas M., Pedersen N., Lackner A., Regier D., Sehgal P., Daniel M., King N., Desrosiers R. 1990; Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. Science 248:1109–1112
    [Google Scholar]
  12. Kestler H. W. III, Ringler D. J., Mori K., Panicali D. L., Sehgal P. K., Daniel M. D., Desrosiers R. C. 1991; Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651–662
    [Google Scholar]
  13. Kulaga H., Folks T., Rutledge R., Truckenmiller M. E., Gugel E., Kindt T. J. 1989; Infection of rabbits with human immunodeficiency virus 1. Journal of Experimental Medicine 169:321–326
    [Google Scholar]
  14. Leonard J. M., Abramczuk J. W., Pezen D. S., Rutledge R., Belcher J. H., Hakim F., Shearer G., Lamperth L., Travis W., Fredrickson T., Notkins A. L., Martin M. A. 1988; Development of disease and virus recovery in transgenic mice containing HIV proviral DNA. Science 242:1665–1670
    [Google Scholar]
  15. Lusso P., Markham P. D., Ranki A., Earl P., Moss B., Dorner F., Gallo R. C., Krohn K. J. E. 1988; Cell-mediated immune response toward viral envelope and core antigens in gibbon apes (Hylobates lar) chronically infected with human immunodeficiency virus-1. Journal of Immunology 141:2467–2473
    [Google Scholar]
  16. McClure M. O., Sattentau Q. J., Beverley P. C. L., Hearn J. P., Fitzgerald A. K., Zuckerman A. J., Weiss R. A. 1987; HIV infection of primate lymphocytes and conservation of the CD4 receptor. Nature, London 330:487–489
    [Google Scholar]
  17. Naidu Y. M., Kestler H. W. III, Li Y., Butler C. V., Silva D. P., Schmidt D. K., Troup C. D., Sehgal P. K., Sonigo P., Daniel M., Desrosiers R. C. 1988; Characterization of infectious molecular clones of simian immunodeficiency virus (SIVMAC) and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly cloned SIVMAC. Journal of Virology 62:4691–4696
    [Google Scholar]
  18. Namikawa R., Kaneshima H., Lieberman M., Weissman I. L., McCune J. M. 1988; Infection of the SCID-hu mouse by HIV-1. Science 242:1684–1686
    [Google Scholar]
  19. Nara P. L., Robey W. G., Arthur L. O., Asher D. M., Wolff A. V., Gibbs C. J. Jr, Gajdusek D. C., Fischinger P. J. 1987; Persistent infection of chimpanzees with human immunodeficiency virus: serological responses and properties of reisolated viruses. Journal of Virology 61:3173–3180
    [Google Scholar]
  20. Ohta Y., Masuda T., Tsujimoto H., Ishikawa K., Kodama T., Morikawa S., Nakai M., Honjo S., Hayami M. 1988; Isolation of simian immunodeficiency virus from African green monkeys and seroepidemiologic survey of the virus in various non-human primates. International Journal of Cancer 41:115–122
    [Google Scholar]
  21. Saiki R. K., Gelfand D. H., Stoffel S., Scharf S. J., Higuchi R., Horn G. T., Mullis K. B., Erlich H. A. 1988; Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491
    [Google Scholar]
  22. Shibata R., Kawamura M., Sakai H., Hayami M., Ishimoto A., Adachi A. 1991; Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. Journal of Virology 65:3514–3520
    [Google Scholar]
  23. Willey R. L., Smith D. H., Laskey L. A., Theodore T. S., Earl P. L., Moss B., Capon D. J., Martin M. A. 1988; In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity. Journal of Virology 62:139–147
    [Google Scholar]
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