1887

Abstract

The E4 region of human adenovirus type 2 is predicted to encode seven proteins as judged from its nucleotide sequence and the pattern of differential splicing of its transcript. Two of the open reading frames (ORFs), ORF1 and ORF2, had been identified as being disrupted in the recently published sequence of the related serotype 5 virus. These ORFs were resequenced and found to be intact in the wt300 strain of adenovirus type 5.

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/content/journal/jgv/10.1099/0022-1317-73-11-2975
1992-11-01
2022-01-20
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References

  1. Chroboczek J., Bieber F., Jacrot B. 1992; The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2. Virology 186:280–285
    [Google Scholar]
  2. Cutt J. R., Shenk T., Hearing P. 1987; Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells. Journal of Virology 61:543–552
    [Google Scholar]
  3. Downey J. F., Rowe D. T., Bacchetti S., Graham F. L., Bayley S. T. 1983; Mapping of a 14000-dalton antigen to early region 4 of the human adenovirus 5 genome. Journal of Virology 45:514–523
    [Google Scholar]
  4. Halbert D. N., Cutt J. R., Shenk T. 1985; Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. Journal of Virology 56:250–257
    [Google Scholar]
  5. Huang M. -M., Hearing P. 1989; Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection. Journal of Virology 63:2605–2615
    [Google Scholar]
  6. Roberts R. J., O’Neill K. E., Yen C. T. 1984; DNA sequences from the adenovirus 2 genome. Journal of Biological Chemistry 259:13968–13985
    [Google Scholar]
  7. Sarnow P., Hearing P., Anderson C. W., Halbert D. N., Shenk T., Levine A. J. 1984; Adenovirus early region 1B 58, 000-dalton tumor antigen is physically associated with an early region 4 25, 000-dalton protein in productively infected cells. Journal of Virology 49:692–700
    [Google Scholar]
  8. Steenbergh P. H., Sussenbach J. S. 1979; The nucleotide sequence of the right-hand terminus of adenovirus type 5 DNA: implications for the mechanism of DNA replication. Gene 6:307–318
    [Google Scholar]
  9. Tigges M., Raskas H. 1984; Splice junctions in adenovirus 2 early region 4 mRNAs: multiple splice sites produce 18 to 24 RNAs. Journal of Virology 50:106–117
    [Google Scholar]
  10. Virtanen A., Gilardi P., Naslund A., LeMoullec J. M., Petterson U., Perricaudet M. 1984; mRNAs from human adenovirus 2 early region 4. Journal of Virology 51:822–831
    [Google Scholar]
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