@article{mbs:/content/journal/jgv/10.1099/0022-1317-73-10-2751, author = "Hunter, Nora and Dann, Janine C. and Bennett, Alan D. and Somerville, Robert A. and McConnell, Irene and Hope, James", title = "Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice", journal= "Journal of General Virology", year = "1992", volume = "73", number = "10", pages = "2751-2755", doi = "https://doi.org/10.1099/0022-1317-73-10-2751", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-73-10-2751", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Congenic mouse strains VM/Dk and VM-Sinc s7/Dk differ at the Sinc gene, which controls the incubation period of scrapie in mice; VM/Dk mice are Sinc p7p7 and VM-Sinc s7/Dk mice are Sinc s7s7. Restriction fragment length polymorphism and DNA sequencing analysis demonstrated that the PrP genes also differ in these strains, confirming the close genetic linkage of Sinc and PrP. Using the restriction enzyme HhaI, we have shown that at least 100 kb of DNA flanking the PrP gene differs between the two strains, and therefore the congruence of the Sinc and PrP genes is still not certain.", }