%0 Journal Article %A Sáiz, J. C. %A Rodríguez, A. %A González, M. %A Alonso, F. %A Sobrino, F. %T Heterotypic Lymphoproliferative Response in Pigs Vaccinated With Foot-and-mouth Disease Virus. Involvement of isolated Capsid Proteins %D 1992 %J Journal of General Virology, %V 73 %N 10 %P 2601-2607 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-73-10-2601 %I Microbiology Society, %X The in vitro viral lymphoproliferative response of pigs vaccinated against foot-and-mouth disease virus (FMDV) has been characterized. Peripheral blood mononuclear cells from immunized animals up to 1 year post-immunization (p.i.) showed a time-dependent FMDV-specific response, as assayed by virus-specific cellular blastogenesis. The optimum viral concentration decreased with time (around 20 weeks p.i.), and the response was faster and weaker. Lymphoproliferation appeared to be mainly due to CD4+ T cells. The response was heterotypic, being induced by all FMDV serotypes tested (C, A and O) after only two vaccinations with FMDV of serotype C (C-S8). Each individual structural protein assessed (VP1, VP2 and VP3) induced proliferation, with VP3 and VP1 being more effective stimulators. In vitro serum neutralization activity and FMDV-specific IgG production were found to be active even at 1 year p.i. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-73-10-2601