@article{mbs:/content/journal/jgv/10.1099/0022-1317-73-10-2601, author = "Sáiz, J. C. and Rodríguez, A. and González, M. and Alonso, F. and Sobrino, F.", title = "Heterotypic Lymphoproliferative Response in Pigs Vaccinated With Foot-and-mouth Disease Virus. Involvement of isolated Capsid Proteins", journal= "Journal of General Virology", year = "1992", volume = "73", number = "10", pages = "2601-2607", doi = "https://doi.org/10.1099/0022-1317-73-10-2601", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-73-10-2601", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "The in vitro viral lymphoproliferative response of pigs vaccinated against foot-and-mouth disease virus (FMDV) has been characterized. Peripheral blood mononuclear cells from immunized animals up to 1 year post-immunization (p.i.) showed a time-dependent FMDV-specific response, as assayed by virus-specific cellular blastogenesis. The optimum viral concentration decreased with time (around 20 weeks p.i.), and the response was faster and weaker. Lymphoproliferation appeared to be mainly due to CD4+ T cells. The response was heterotypic, being induced by all FMDV serotypes tested (C, A and O) after only two vaccinations with FMDV of serotype C (C-S8). Each individual structural protein assessed (VP1, VP2 and VP3) induced proliferation, with VP3 and VP1 being more effective stimulators. In vitro serum neutralization activity and FMDV-specific IgG production were found to be active even at 1 year p.i.", }