1887

Abstract

An epitope involved in neutralization of foot-and-mouth disease virus (FMDV) of subtype C was generated by a single amino acid replacement in VP1 of FMDV of subtype C. The replacement [Ser (139) → Ile, in the immunodominant site A] was consistently found in those FMDV C Santa Pau-Sp/70 mutants resistant to neutralization by monoclonal antibody (MAb) SD6 (specific for most C viruses) that acquired the capacity to be neutralized by MAb 7AB5 (specific for C viruses).

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1992-01-01
2021-10-18
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References

  1. Acharya R., Fry E., Stuart D., Fox G., Rowlands D., Brown F. 1989; The three-dimensional structure of foot-and-mouth disease virus at 2-9 A resolution. Nature, London 337:709–716
    [Google Scholar]
  2. Bachrach H. L. 1968; Foot-and-mouth disease virus. Annual Review of Microbiology 22:201–224
    [Google Scholar]
  3. Domingo E., Mateu M. G., Martinez M. A., Dopazo J., Moya A., Sobrino F. 1990; Genetic variability and antigenic diversity of foot-and-mouth disease virus. In Applied Virology Research vol 2 pp 233–266 Edited by Kurstak E., Marusyk R. G. F. A. Murphy V. M. H. van Regenmortel; New York: Plenum Press
    [Google Scholar]
  4. Dopazo J., Sobrino F., Palma E. L., Domingo E., Moya A. 1988; Gene encoding capsid protein VP1 of foot-and-mouth disease virus: a quasispecies model of molecular evolution. Proceedings of the National Academy of Sciences, U.S.A. 85:6811–6815
    [Google Scholar]
  5. Fagg R. H., Hyslop N. St G. 1966; Isolation of a variant strain of foot-and-mouth disease virus (type O) during passage in partly immunized cattle. Journal of Hygiene 64:397–404
    [Google Scholar]
  6. Kitson J. D. A., McCahon D., Belsham G. J. 1990; Sequence analysis of monoclonal antibody resistant mutants of type O foot- and-mouth disease virus: evidence for the involvement of the three surface exposed capsid proteins in four antigenic sites. Virology 179:26–34
    [Google Scholar]
  7. Martinez M. A., Hernandez J., Piccone M. E., Palma E. L., Domingo E., Knowles N., Mateu M. G. 1991; Two mechanisms of antigenic diversification of foot-and-mouth disease virus. Virology 184:695–706
    [Google Scholar]
  8. Mateu M. G., Rocha E., Vicente O., Vayreda F., Navalpotro C., Andreu D., Pedroso E., Giralt E., Enjuanes L., Domingo E. 1987; Reactivity with monoclonal antibodies of viruses from an episode of foot-and-mouth disease virus. Virus Research 8:261–274
    [Google Scholar]
  9. Mateu M. G., Da Silva J. L., Rocha E., De Brum D. L., Alonso A., Enjuanes L., Domingo E., Barahona H. 1988; Extensive antigenic heterogeneity of foot-and-mouth disease virus of serotype C. Virology 167:113–124
    [Google Scholar]
  10. Mateu M. G., Martinez M. A., Rocha E., Andreu D., Parejo J., Giralt E., Sobrino F., Domingo E. 1989; Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus. Proceedings of the National Academy of Sciences, U.S.A. 86:5883–5887
    [Google Scholar]
  11. Mateu M. G., Martinez M. A., Capucci L., Andreu D., Giralt E., Sobrino F., Brocchi E., Domingo E. 1990; A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C. Journal of General Virology 71:629–637
    [Google Scholar]
  12. Parry N., Fox G., Rowlands D., Brown F., Fry E., Acharya R., Logan D., Stuart D. 1990; Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus. Nature, London 347:569–572
    [Google Scholar]
  13. Pereira H. G. 1977; Subtyping of foot-and-mouth disease virus. In Developments in Biological Standardization vol 35 pp 333–363 Edited by Mackowiak C., Regamey R. H. Basel: S. Karger;
    [Google Scholar]
  14. Piccone M. E., Kaplan G., Giavedoni L., Domingo E., Palma E. L. 1988; VP1 of serotype C foot-and-mouth disease virus: longterm conservation of sequences. Journal of Virology 62:1469–1473
    [Google Scholar]
  15. Prabhakar B. S., Menegus M. A., Notkins A. L. 1985; Detection of conserved and nonconserved epitopes on coxackievirus B4: frequency of antigenic change. Virology 146:302–306
    [Google Scholar]
  16. Strohmaier K., Franze R., Adam K.-H. 1982; Location and characterization of the antigenic portion of the FMDV immunizing protein. Journal of General Virology 59:295–306
    [Google Scholar]
  17. Takahashi H., Merli S., Putney D., Houghten R., Moss B., Germain R. N., Berzofsky J. A. 1989; A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gpl60. Science 246:118–121
    [Google Scholar]
  18. Villaverde A., Martinez M. A., Sobrino F., Dopazo J., Moya A., Domingo E. 1991; Fixation of mutations in the VP1 gene of foot-and-mouth disease virus. Can quasispecies define a transient molecular clock?. Gene 103147–153
    [Google Scholar]
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