RT Journal Article SR Electronic(1) A1 Lal, Renu B. A1 Rudolph, Donna L. A1 Palker, Thomas J. A1 Coligan, John E. A1 Folks, Thomas M.YR 1991 T1 A synthetic peptide elicits antibodies reactive with the external glycoprotein of human T cell lymphotropic virus type I JF Journal of General Virology, VO 72 IS 9 SP 2321 OP 2324 DO https://doi.org/10.1099/0022-1317-72-9-2321 PB Microbiology Society, SN 1465-2099, AB A synthetic peptide derived from the external glycoprotein of human T cell lymphotropic virus type I (HTLV-I) (Env-5; amino acids 242 to 256) reacted with IgG antibodies in serum specimens from HTLV-I-infected individuals. C-terminal residues of Env-5 were crucial for the antibody reactivity. Polyclonal rabbit antibodies to Env-5 did not inhibit syncytium formation but such antibodies reacted specifically with gp68env and gp46env glycoproteins of HTLV-I in an immunoblot analysis. Immunoprecipitation of the surface-labelled MT-2 (HTLV-I-infected) cell line with anti-Env-5 precipitated the gp68env precursor protein. It was concluded that peptide Env-5 mimics a surface-exposed epitope on the HTLV-I external glycoprotein., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-72-9-2321