1887

Abstract

Using sera from hosts infected with bovine leukaemia virus (BLV), human T cell lymphoma virus types I and II (HTLV-I and -II), or simian T cell lymphoma virus type I (STLV-I), we found that the major proteins of these viruses cross-react immunologically. The specificity of this cross-reactivity was demonstrated by absorption using purified viral proteins, virus lysates and extracts of infected cells. The data strongly suggested that the cross-reacting epitope(s), referred to as CE, differs from those responsible for cross-reactions between the major proteins of HTLV-I, HTLV-II and STLV-I, and between those of BLV and HTLV-I reported previously. The prevalence of antibodies to CE was low, even amongst infected hosts with high titres to other epitopes present in the major proteins of the homologous viruses. CE was not detected in any of the other C- or D-type retroviruses, or lentiviruses examined. Therefore, it is likely that CE can be used to define serologically a subgroup of C-type retroviruses, the genomes of which display unique features and functional activities.

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1991-09-01
2021-10-28
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References

  1. Chen I. S. Y., McLaughlin J., Golde D. W. 1984; Long terminal repeats of human T-cell leukemia virus II genome determine target cell specificity. Nature, London 309:276–279
    [Google Scholar]
  2. Daniel M. D., Letvin N. L., Sehgal P. K., Schmidt D. K., Silva D. P., Solomon K. R., Hodi F. S. Jr, Ringler D. T., Hunt R. D., King N. W., Desrosiers R. C. 1988; Prevalence of antibodies to 3 retroviruses in a captive colony of macaque monkeys. International Journal of Cancer 41:601–608
    [Google Scholar]
  3. Diglio C. A., Ferrer J. F. 1976; Induction of syncytia by the bovine C-type leukemia virus. Cancer Research 36:1056–1067
    [Google Scholar]
  4. Ferrer J. F. 1972; Antigenic comparison of bovine type C virus with murine and feline leukemia viruses. Cancer Research 32:1871–1877
    [Google Scholar]
  5. Ferrer J. F., Abt D. A., Bhatt D. M., Marshak R. R. 1974; Studies on the relationship between infection with bovine C-type virus, leukemia and persistent lymphocytosis in cattle. Cancer Research 34:893–900
    [Google Scholar]
  6. Ferrer J. F., Marshak R. R., Abt D. A., Kenyon S. J. 1979; Relationship between lymphosarcoma and persistent lymphocytosis in cattle. A review. Journal of the American Veterinary Medical Association 175:705–708
    [Google Scholar]
  7. Gilden R. V., Long C. W., Hanson M., Toni R., Charman H. P., Oroszlan S., Miller J. M., Van Der Maaten M. J. 1975; Characteristics of the major internal protein and RNA-dependent DNA polymerase of bovine leukaemia virus. Journal of General Virology 29:305–314
    [Google Scholar]
  8. Graves D. C., Diglio C. A., Ferrer J. F. 1977; A reverse transcriptase assay for detection of the bovine leukemia virus. American Journal of Veterinary Research 38:1739–1744
    [Google Scholar]
  9. Greenwood F. C., Hunter W. M., Glover J. S. 1963; The preparation of 131I-labelled human growth hormone of high specific radioactivity. Biochemical Journal 89:114–123
    [Google Scholar]
  10. Gupta P., Ferrer J. F. 1981; Comparison of various serological and direct methods for the diagnosis of BLV infection in cattle. International Journal of Cancer 28:179–184
    [Google Scholar]
  11. Johnson D. A., Gautsch J. W., Sportsman J. R., Elder J. H. 1984; Improved technique utilizing nonfat dry milk for analysis of proteins and nucleic acids transferred to nitrocellulose. Gene Analysis Techniques 1:3–8
    [Google Scholar]
  12. Kalyanaraman V. S., Sarngadharan M. G., Bunn P. A., Minna J. D., Gallo R. C. 1981a; Antibodies to human sera reactive against an internal structural protein of human T-cell lymphoma virus. Nature, London 294:271–273
    [Google Scholar]
  13. Kalyanaraman V. S., Sarngadharan M. G., Poiesz B. J., Ruscetti F. W., Gallo R. C. 1981b; Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma and comparison to other mammalian retroviruses. Journal of Virology 38:906–915
    [Google Scholar]
  14. Kenyon S. J., Ferrer J. F., McFeely R. A., Graves D. C. 1981; Induction of lymphosarcoma in sheep by bovine leukemia virus. Journal of the National Cancer Institute 67:1157–1163
    [Google Scholar]
  15. Laemmli U. K. 1970; Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, London 227:680–685
    [Google Scholar]
  16. McDonald H. C., Ferrer J. F. 1976; Detection, quantitation and characterization of the major internal virion antigen of the bovine leukemia virus by radioimmunoassay. Journal of the National Cancer Institute 57:875–882
    [Google Scholar]
  17. McDonald H. C., Graves D. C., Ferrer J. F. 1976; Isolation and characterization of an antigen of the bovine C-type virus. Cancer Research 36:1251–1257
    [Google Scholar]
  18. Maruyama K., Frikushima T., Mochizuki S. 1989; Cross reactive antibodies to BLV and HTLV in bovine and human hosts with retrovirus infection. Journal of Veterinary Immunology and Immunopathology 22:265–273
    [Google Scholar]
  19. Migushi T., Kubonishi T., Shizuo Y., Akayi F., Oktsuki G., Shiroishi Y., Nagata T., Hinuma G. 1981; Type C virus particles in a cord T-cell line derived by cocultivating normal human cord leukocytes and human leukaemic T-cells. Nature, London 294:770–771
    [Google Scholar]
  20. Nerukar L. S., Wong-Staal F., Gallo R. C. 1990; Human retroviruses, leukemia and AIDS. In Leukemia, 5th. edn., pp 225–252 Edited by Mackey T. Philadelphia: W. B. Saunders;
    [Google Scholar]
  21. Onuma M., Tsukiyama K., Ohya K., Morishima Y., Ohno R. 1987; Detection of cross-reactive antibody to BLV p24 in sera of human patients infected with HTLV. Microbiology and Immunology 31:131–137
    [Google Scholar]
  22. Oroszlan S., Sarngadharan M. G., Copeland T. D., Kalyanaraman V. S., Gilden R. V., Gallo R. C. 1982; Primary structure analysis of the major internal protein p24 of human type C T-cell leukemia virus. Proceedings of the National Academy of Sciences, U.S.A. 79:1291–1294
    [Google Scholar]
  23. Oroszlan S., Copeland T. D., Kalyanaraman V. S., Sarngadharan M. G., Schultz A. M., Gallo R. C. 1984; Chemical analysis of human T-cell leukemia virus structural proteins. In Human T-Cell Leukemia/Lymphoma Virus pp 101–110 Edited by Gallo R. C., Essex M. E., Gross L. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  24. Popovic M., Sarngadharan M. G., Read E., Gallo R. C. 1984; Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224:497–500
    [Google Scholar]
  25. Rasty S., Dhruva B. R., Schiltz R. L., Shih D. S., Isset C. J., Montelaro R. C. 1990; Proviral DNA integration and transcriptional patterns of equine infectious anemia virus during persistent and cytopathic infections. Journal of Virology 64:86–95
    [Google Scholar]
  26. Robert-Guroff M., Nakao M., Notake K., Ito Y., Sliski A., Gallo R. C. 1982; Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T-cell leukemia. Science 215:975–978
    [Google Scholar]
  27. Schupbach J. 1989; Human retroviology: facts and concepts. Current Topics in Microbiology and Immunology 142:1–115
    [Google Scholar]
  28. Voevodin A. F., Lapin B. A., Yakovleva L. A., Ponomaryeva T. I., Oganyan T. E., Razmadze E. N. 1985; Antibodies reacting with human T-lymphotropic retrovirus (HTLV-I) or related antigens in lymphomatous and healthy hamadryas baboons. International Journal of Cancer 36:579–584
    [Google Scholar]
  29. Weiss R. 1984; RNA tumor viruses. In Molecular Biology of Tumor Viruses, 2nd. edn., vol 2 pp 405–485 Edited by Weiss R. A., Teich N. M., Varmus H. E., Coffin J. M. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  30. Yoshida M. 1987; Expression of the HTLV-I genome and its association with a unique T-cell malignancy. Biochimica et biophysica acta 907:145–161
    [Google Scholar]
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