1887

Abstract

The sequence of the H gene and flanking sequences in the F and L genes of canine distemper virus (CDV) have been determined. The H gene of CDV (1946 nucleotides) contains one large open reading frame starting at position 21 and terminating at position 1835, encoding a protein of 604 amino acid residues. This protein contains three potential glycosylation sites in the extracellular domain and, like all other paramyxoviruses, a N-terminal membrane-spanning hydrophobic anchor domain. The deduced H protein sequence shows an identity of 36% with rinderpest virus (RPV) and measles virus (MV). The identities at the nucleotide level are higher (RPV 52% and MV 53%). The amino acid sequence shows conservation of all the structural determinants with the H proteins of MV and RPV. The data also show that CDV is evolutionarily equidistant to RPV and MV with respect to the H gene.

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1991-02-01
2024-07-25
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References

  1. Alkhatib G., Briedis D. J. 1986; The predicted structure of the measles virus hemagglutinin. Virology 150:479–490
    [Google Scholar]
  2. Barrett T., Shrimpton S. B., Russell S. E. H. 1985; Nucleotide sequence of the entire protein coding region of canine distemper virus polymerase-associated (P) protein mRNA. Virus Research 3:367–372
    [Google Scholar]
  3. Barrett T., Clarke D. K., Evans S. A., Rima B. K. 1987; The nucleotide sequence of the gene encoding the F protein of canine distemper virus: a comparison of the deduced amino acid sequence with other paramyxoviruses. Virus Research 8:373–386
    [Google Scholar]
  4. Barrett T., Subbarao S. M., Belsham G. J., Mahy B. W. J. 1991; The molecular biology of the morbilliviruses. In The Paramyxoviruses pp. 83–102 Edited by Kingsbury D. W. New York & London: Plenum Press;
    [Google Scholar]
  5. Bellini W. J., Englund G., Richardson C. D., Rozenblatt S., Lazzarini R. A. 1986; Matrix genes of measles virus and canine distemper virus: cloning, nucleotide sequences and deduced amino acid sequences. Journal of Virology 58:408–416
    [Google Scholar]
  6. Cattaneo R., Rebmann G., Schmid A., Baczko K., Ter Meulen V., Billeter M. A. 1987; Altered transcription of a defective measles virus genome derived from a diseased human brain. EMBO Journal 6:681–688
    [Google Scholar]
  7. Cattaneo R., Schmid A., Spielhofer P., Kaelin K., Baczko K., Ter Meulen V., Pardowitz J., Flanagan S., Rima B. K., Udem S. A., Billeter M. A. 1989; Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases. Virology 173:415–425
    [Google Scholar]
  8. Gerald C., Buckland R., Barker R., Freeman G., Wild T. F. 1686; Measles virus haemagglutinin gene: cloning, complete nucleotide sequence analysis and expression in COS cells. Journal of General Virology 67:2695–2703
    [Google Scholar]
  9. Gupta K. C., Kingsbury D. W. 1984; Complete sequences of the intergenic and mRNA start signals in the Sendai virus genome: homologies with the genome of VSV. Nucleic Acids Research 12:3829–3841
    [Google Scholar]
  10. Horisberger M. A., Destritz C., Content J. 1980; Intracellular glycosylation of influenza hemagglutinin: the effect of glucosamine. Archives of Virology 64:9–16
    [Google Scholar]
  11. Keil W., Klenk H. D., Schwarz R. T. 1979; Carbohydrates of influenza virus. III. Nature of oligosaccharide protein linkage in viral glycoproteins. Journal of Virology 31:253–256
    [Google Scholar]
  12. Kozak M. 1986; Point mutations define a sequence flanking the AUG initiator codon that modulate translation by eukaryotic ribosomes. Cell 44:283–292
    [Google Scholar]
  13. Morrison T. G. 1988; Structure, function and intracellular processing of paramyxovirus membrane proteins. Virus Research 10:113–136
    [Google Scholar]
  14. Norrby E., Sheshberadaran H., McCullough K. C., Carpenter W. C., Ӧrvell C. 1985; Is rinderpest virus the archevirus of the morbillivirus genus?. Intervirology 23:228–232
    [Google Scholar]
  15. Rima B. K. 1983; The proteins of morbilliviruses. Journal of General Virology 64:1205–1219
    [Google Scholar]
  16. Rima B. K., Baczko K., Clarke D. K., Curran M. D., Martin S. J., Billeter M. A., Ter Meulen V. 1986; Characterization of clones for the sixth (L) gene and a transcriptional map for morbilliviruses. Journal of General Virology 67:1971–1978
    [Google Scholar]
  17. Rozenblatt S., Eizenberg O., Ben-Levy R., Lavie V., Bellini W. J. 1985; Sequence homology within morbilliviruses. Journal of Virology 53:684–690
    [Google Scholar]
  18. Russell S. E. H., Clarke D. K., Hoey E. M., Rima B. K., Martin S. J. 1985; cDNA cloning of the messenger RNAs of five genes of canine distemper virus. Journal of General Virology 66:433441
    [Google Scholar]
  19. Sanger F., Nicklen S., Coulson A. R. 1977; DNA sequencing with chain-terminating inhibitors. Proceedings of the National Academy of Sciences, U.S.A 74:5463–5467
    [Google Scholar]
  20. Sheshberadaran H., Norrby E., McCullough K. C., Carpenter W. C., Ӧrvell C. 1986; The antigenic relationship between measles, canine distemper and rinderpest viruses studied with monoclonal antibodies. Journal of General Virology 67:1381–1392
    [Google Scholar]
  21. Spriggs M. K., Collins P. L. 1986; Human parainfluenza virus type 3: mRNAs, polypeptide coding assignments, intergenic sequences and genetic map. Journal of Virology 59:649–654
    [Google Scholar]
  22. Tsukiyama K., Sugiyama M., Yoshikawa Y., Yamanouchi K. 1987; Molecular cloning and sequence analysis of the rinderpest virus mRNA encoding the hemagglutinin protein. Virology 160:4854
    [Google Scholar]
  23. Yamanaka M., Hsu D., Crisp T., Dale B., Grubman M., Yilma T. 1988; Cloning and sequence analysis of the hemagglutinin gene of the virulent strain of rinderpest virus. Virology 166:251–253
    [Google Scholar]
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