1887

Abstract

Wild duck populations were investigated over a 4 year period for duck hepatitis B virus (DHBV) infection and liver disease. It appeared that DHBV is endemic in wild migratory mallards from France and the U.S.A., although neither hepatocellular carcinoma nor viral DNA integration could be detected in liver samples examined. The follow up of natural infection indicated that wild mallards developed significantly higher serum titres to DHBV DNA than Pekin ducks. The results of experimental transmission demonstrated that such differences in viraemia were not related to the breed of ducks but to the virus isolate, since the wild mallard-isolated DHBV (DHBV) induced significantly higher viraemia in both mallard and Pekin ducklings compared to the domestic Pekin DHBV (DHBV) isolate. The naturally infected mallard and Pekin ducks had only minor histological lesions of the liver compared with experimentally infected birds. There was no correlation between the intensity of viraemia and the severity of liver lesions, suggesting that as for mammalian hepadnaviruses the hepatic injury in DHBV-infected ducks is probably immunologically mediated.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-72-2-417
1991-02-01
2021-10-27
Loading full text...

Full text loading...

/deliver/fulltext/jgv/72/2/JV0720020417.html?itemId=/content/journal/jgv/10.1099/0022-1317-72-2-417&mimeType=html&fmt=ahah

References

  1. Alberti A. 1990; Do single nucleotide mutations result in clinically significant changes in hepatitis B virus pathogenicity?. Journal of Hepatology 10:268–270
    [Google Scholar]
  2. Alberti A., Tremolada F., Fattovich G., Bortolotti F., Realdi G. 1983; Virus replication and liver disease in chronic hepatitis B virus infection. Digestive Diseases and Sciences 28:962–966
    [Google Scholar]
  3. Brunetto M. R., Stemler M., Schodel F., Will H., Ottobrelli A., Rizetto M., Bonino F. 1989; Identification of HBV variants which cannot produce precore derived HBeAg and may be responsible for severe hepatitis. Italian Journal of Gastroenterology 21:151–154
    [Google Scholar]
  4. Carman W. E., Jacyna M. R., Hadziyannis S., Karayiannis P., McGarvey M. J., Makris A., Thomas H. C. 1989; Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 8663:588–591
    [Google Scholar]
  5. Cova L., Hantz O., Arliaud-Gassin M., Chevalier A., Berthillon P., Boulay J., Jacquet C., Chomel B., Vitvitski L., Trepo C. 1985; Comparative study of DHBV levels and endogenous DNA polymerase activity in naturally infected ducklings in France. Journal of Virological Methods 10:251–260
    [Google Scholar]
  6. Cova L., Lambert V., Chevalier A., Hantz O., Fourel I., Jacquet C., Pichoud C., Boulay J., Chomel B., Vitvitski L., Trepo C. 1986; Evidence for the presence of duck hepatitis B virus in wild migrating ducks. Journal of General Virology 67:537–547
    [Google Scholar]
  7. Cova L., Wild C. P., Mehrotra R., Turusov V., Shirai T., Lambert V., Jacquet C., Tomatis L., Trepo C., Montesano R. 1990; Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks. Cancer Research 50:2156–2163
    [Google Scholar]
  8. Fourel I., Gripon P., Hantz O., Cova L., Lambert V., Jacouet C., Watanabe K., Fox J., Guillouzo C., Trepo C. 1989; Prolonged duck hepatitis B virus replication in duck hepatocytes cocultivated with rat epithelial cells: a useful system for antiviral testing. Hepatology 10:186–191
    [Google Scholar]
  9. Frommel D., Crevat D., Vitvitski L., Pichoud C., Hantz O., Chevalier M., Grimaud J. A., Lindberg J., Trepo C. 1984; Immunopathologic aspects of woodchuck hepatitis. American Journal of Pathology 115:125–134
    [Google Scholar]
  10. Fukuda R., Fukumoto S., Shimada Y. 1987; A sequential study of viral DNA in serum in experimental transmission of duck hepatitis virus. Journal of Medical Virology 21:311–320
    [Google Scholar]
  11. Galle P. R., Schlicht H. J., Fischer M., Schaller H. 1988; Production of infectious duck hepatitis B virus in a human hepatoma cell line. Journal of Virology 62:1736–1740
    [Google Scholar]
  12. Jllbert A., FreimaN J., Burrell C. J., Holmes M., Gowans E. J., Rowland R., Hall P., Cossart Y. E. 1988; Virus-liver cell interaction in duck hepatitis B virus infection. Gastroenterology 95:1375–1382
    [Google Scholar]
  13. Lambert V., Fernholz D., Sprengel R., Fourel I., Deleage G., Wildner G., Peyret C., Trepo C., Cova L., Will H. 1990; Virus-neutralizing monoclonal antibody to a conserved epitope on the duck hepatitis B virus pre-S protein. Journal of Virology 64:1290–1297
    [Google Scholar]
  14. Marion P. L., Knight S. S., Ho B. K., Guo Y. Y., Robinson W. S., Popper H. 1984; Liver disease associated with duck hepatitis B virus infection of domestic ducks. Proceedings of the National Academy of Sciences, U,. S,. A 81:898–902
    [Google Scholar]
  15. Marion P. L., Van Davelaar M. J., Knight S. S., Salazar F. H., Garcia G., Popper H., Robinson W. S. 1986; Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virus. Proceedings of the National Academy of Sciences, U,. S,. A 83:4543–4546
    [Google Scholar]
  16. Popper H., Shih J. W. K., Gerin J. L., Wong D. C., Hoyer B. H., London W. T., Sly D., Purcell R. H. 1981; Woodchuck hepatitis and hepatocellular carcinoma: correlation of histologic with virologic observations. Hepatology 1:91–98
    [Google Scholar]
  17. Popper H., Roth L., Purcell R. H., Tennant B. C., Gerin J. L. 1987; Hepatocarcinogenicity of the woodchuck hepatitis B virus. Proceedings of the National Academy of Sciences, USA 84:866–870
    [Google Scholar]
  18. Rigby P. W. J., Dieckmann M., Rhodes C., Berg P. 1977; Labelling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. Journal of Molecular Biology 113:237–251
    [Google Scholar]
  19. Schodel F., Sprengel R., Weimer T., Fernholz D., Schneider R., Will H. 1989; Animal hepatitis B viruses. In Advances in Viral Oncology pp. 73–102 Edited by Klein G. New York: Raven Press;
    [Google Scholar]
  20. Solomon J. B. 1966; Induction of antibody formation to goat erythrocytes in the developing chick embryo and effects of maternal antibody. Immunology 11:89–96
    [Google Scholar]
  21. Sprengel R., Kaleta E. F., Will H. 1988; Isolation and characterization of a hepatitis B virus endemic in herons. Journal of Virology 62:3832–3839
    [Google Scholar]
  22. Tong S., Li J. S., Vitvitski L., Trepo C. 1990; Active hepatitis virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region. Virology 176:596–603
    [Google Scholar]
  23. Yokosuka O., Omata M., Zhou Y. Z., Imazeki F., Okuda K. 1985; Duck hepatitis B virus DNA in liver and serum of Chinese ducks: integration of viral DNA in a hepatocellular carcinoma. Proceedings of the National Academy of Sciences, U,. S,. A. 176:5180–5184
    [Google Scholar]
  24. Zhou Y. Z. 1980; A virus possibly associated with hepatitis and hepatoma in ducks. Shanghai Medical Journal 3:641–644
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-72-2-417
Loading
/content/journal/jgv/10.1099/0022-1317-72-2-417
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error