Variation in the characteristics of 10 mouse-passaged scrapie lines derived from five scrapie-positive sheep

References

1. Bolton D. C., Bendheim P. E. 1985; A modified host protein model of scrapie. In Novel Infectious Agents and the Central Nervous System, Ciba Foundation Symposium vol 135 pp. 164–177 Edited by Bock G., Marsh J. Chichester: John Wiley and Sons;
   [Google Scholar]
2. Carp R. I., Callahan S. M., Sersen E. A., Moretz R. C. 1984; Preclinical changes in weight of scrapie-infected mice as a function of scrapie agent-mouse strain combination. Intervirology 21:61–69
   [Google Scholar]
3. Carp R. I., Merz P. A., Moretz R. C., Somerville R. A., Callahan S. M., Wisniewski H. M. 1985; Biological properties of scrapie: an unconventional slow virus. In Subviral Pathogens of Plants and Animals: Viroids and Prions pp. 425–464 Edited by Maramorosch K., McKelvey J. J. New York: Academic Press;
   [Google Scholar]
4. Carp R. I., Moretz R. C., Natelli M., Dickinson A. G. 1987; Genetic control of scrapie: incubation period and plaque formation in I mice. Journal of General Virology 68:401–407
   [Google Scholar]
5. Carp R. I., Kascsak R. J., Wisniewski H. M., Merz P. A., Rubenstein R., Bendheim P., Bolton D. 1989a; The nature of the unconventional slow infection agents remains a puzzle. Alzheimer Disease and Associated Disorders 3:79–99
   [Google Scholar]
6. Carp R. I., Kim Y. S., Kascsak R. J., Merz P. A., Rubenstein R. 1989b; Classic genetics of scrapie. In Alzheimer’s Disease and Related Disorders pp. 567–582 Edited by Iqbal K., Wisniewski H. M., Winblad B. New York: Alan R. Liss;
   [Google Scholar]
7. Carp R. I., Kim Y. S., Callahan S. M. 1989c; Scrapie-induced alterations in glucose tolerance in mice. Journal of General Virology 70:827–835
   [Google Scholar]
8. Czub M., Braig H. R., Diringer H. 1986; Pathogenesis of scrapie: study of the temporal development of clinical symptoms, of infectivity titres and scrapie-associated fibrils in brains of hamsters infected intraperitoneally. Journal of General Virology 67:2005–2009
   [Google Scholar]
9. Czub M., Braig H. R., Diringer H. 1988; Replication of scrapie agent in hamsters infected intracerebrally confirms the pathogenesis of an amyloid-inducing virosis. Journal of General Virology 69:1753–1756
   [Google Scholar]
10. Dickinson A. G., Fraser H. 1977; Scrapie pathogenesis in inbred mice: an assessment of host control and response involving many strains of agent. In Slow Virus Infections of the Central Nervous System pp. 3–14 Edited by Ter Meulen V., Katz M. New York: Springer-Verlag;
    [Google Scholar]
11. Dickinson A. G., Fraser H. 1979; An assessment of the genetics of scrapie in sheep and mice. In Slow Transmissible Diseases of the Nervous System vol 1 pp. 367–385 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
12. Dickinson A. G., Meikle V. M. H. 1971; Host genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent. Molecular and General Genetics 112:73–79
    [Google Scholar]
13. Dickinson A. G., Outram G. W. 1979; The scrapie replication site hypothesis and its implications for pathogenesis. In Slow Transmissible Diseases of the Nervous System vol 2 pp. 13–32 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
14. Dickinson A. G., Outram G. W. 1983; Operational limitations in the characterization of the infective units of scrapie. In Virus Non Conventionnels et Affections du Système Nerveux Central pp. 3–16 Edited by Court L. A., Cathala F. Paris: Masson;
    [Google Scholar]
15. Dickinson A. G., Bruce M. E., Fraser H., Kimberlin R. H. 1984; Scrapie strain differences: the implications of stability and mutation. In Proceedings of Workshop on Slow Transmissible Diseases pp. 105–118 Edited by Tateishi J. Tokyo: Japanese Ministry of Health and Welfare;
    [Google Scholar]
16. Fraser H. 1979; The neuropathology of scrapie: the precision of the lesions and their diversity. In Slow Transmissible Diseases of the Nervous System vol 1 pp. 387–406 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
17. Gajdusek D. C. 1977; Unconventional viruses and the origin and disappearance of kuru. Science 197:943–960
    [Google Scholar]
18. Hadlow W. J., Race R. E., Kennedy R. C., Eklund C. M. 1979; Natural infection of sheep with scrapie virus. In Slow Transmissible Diseases of the Nervous System vol 2 pp. 3–12 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
19. Kim Y. S., Carp R. I., Callahan S. M., Wisniewski H. M. 1987a; Incubation periods and survival times for mice injected stereotaxically with three scrapie strains in different brain regions. Journal of General Virology 68:695–702
    [Google Scholar]
20. Kim Y. S., Carp R. I., Callahan S. M., Wisniewski H. M. 1987b; Scrapie-induced obesity in mice. Journal of Infectious Diseases 156:402–405
    [Google Scholar]
21. Kimberlin R. H. 1979; Early events in the pathogenesis of scrapie in mice: biological and biochemical studies. In Slow Transmissible Diseases of the Nervous System vol 2 pp. 33–54 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
22. Kimberlin R. H. 1982; Scrapie agent: prions or virinos?. Nature, London 297:107–108
    [Google Scholar]
23. Kimberlin R. H. 1984; Scrapie: the disease and the infectious agent. Trends in Neurosciences 7:312–316
    [Google Scholar]
24. Kimberlin R. H., Walker C. A. 1977; Characteristics of a short incubation model of scrapie in the golden hamster. Journal of General Virology 34:295–304
    [Google Scholar]
25. Kimberlin R. H., Walker C. A. 1978; Evidence that the transmission of one source of scrapie agent to hamsters involves separation of agent strains from a mixture. Journal of General Virology 39:487–496
    [Google Scholar]
26. Kimberlin R. H., Walker C. A. 1983; Invasion of the CNS by scrapie agent and its spread to different parts of the brain. In Virus Non Conventionnels et Affections du Système Nerveux Central pp. 17–33 Edited by Court L. A., Cathala F. Paris: Masson;
    [Google Scholar]
27. Kimberlin R. H., Cole S., Walker C. A. 1987; Temporary and permanent modifications to a single strain of mouse scrapie on transmission to rats and hamsters. Journal of General Virology 68:1875–1881
    [Google Scholar]
28. Kimberlin R. H., Walker C. A., Fraser H. 1989; The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice. Journal of General Virology 70:2017–2025
    [Google Scholar]
29. Manuelidis L., Murdoch G., Manuelidis E. E. 1988; Potential involvement of retroviral elements in human dementias. In Novel Infectious Agents and the Central Nervous System, Ciba Foundation Symposium vol 135 pp. 117–134 Edited by Bock G., Marsh J. Chichester: John Wiley and Sons;
    [Google Scholar]
30. Outram G. W. 1972; Changes in drinking and feeding habits of mice with experimental scrapie. Journal of Comparative Pathology 82:415–427
    [Google Scholar]
31. Prusiner S. B. 1982; Novel proteinaceous infectious particles cause scrapie. Science 216:136–144
    [Google Scholar]
32. Prusiner S. B. 1987; Prions and neurodegenerative diseases. New England Journal of Medicine 317:1571–1598
    [Google Scholar]
33. Prusiner S. B., Gabizon R., McKinley M. P. 1987; On the biology of prions. Acta neuropathologica 72:299–314
    [Google Scholar]
34. Rohwer R. G. 1984a; Scrapie infectious agent is virus-like in size and susceptibility to inactivation. Nature, London 308:658–662
    [Google Scholar]
35. Rohwer R. G. 1984b; Virus-like sensitivity of the scrapie agent to heat inactivation. Science 223:600–602
    [Google Scholar]