1887

Abstract

Lymphocytes from mice immunized with human rhinovirus (HRV) serotypes 1A or 15 proliferated in response to HRV and the activated cells were shown to be helper T (Th) cells. Lymphocytes from mice primed with HRV-1A responded to seven of eight heterologous virus serotypes, the responses to other minor cell receptor group viruses being greater than to those belonging to the major cell receptor group. A similar bias was seen with cells from mice primed with HRV-15 in that they responded preferentially to other major receptor group viruses. This pattern of cross-serotype recognition was shown to be similar in three inbred mouse strains and was not dependent upon the major histocompatibility complex haplotype. These results have revealed that there are determinants within the viral proteins of a number of serotypes of HRV that are recognized by Th cells primed against a single HRV serotype. Thus, at the level of Th cell recognition of HRV, a cross-serotype reactivity is seen which is not reflected in the B cell antibody response to virus, which is generally highly serotype-specific.

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1991-12-01
2024-12-12
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References

  1. Abraham F., Colonno R. J. 1984; Many rhinovirus serotypes share the same cellular receptor. Journal of Virology 51:340–345
    [Google Scholar]
  2. Appleyard G., Russell S. M., Clarke B. E., Speller S. A., Trowbridge M., Vadolas J. 1990; Neutralization epitopes of human rhinovirus type 2. Journal of General Virology 71:1275–1282
    [Google Scholar]
  3. Bynoe M. L., Hobson D., Horner J., Kipps A., Schild G. C., Tyrrell D. A. J. 1961; Inoculation of human volunteers with a strain of virus isolated from a common cold. Lancet i:1194–1196
    [Google Scholar]
  4. Clatch R. J., Lipton H. L., Miller S. D. 1987; Class II-restricted T-cell responses in Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease. II. Survey of host immune responses and central nervous virus titres in inbred mouse strains. Microbial Pathogenesis 3:327–337
    [Google Scholar]
  5. Collen T., Doel T. R. 1990; Heterotypic recognition of foot-and-mouth disease virus by cattle lymphocytes. Journal of General Virology 71:309–315
    [Google Scholar]
  6. Colonno R. J., Callahan P. L., Long W. J. 1986; Isolation of a monoclonal antibody that blocks attachment of the major group of human rhinoviruses. Journal of Virology 57:7–12
    [Google Scholar]
  7. Cooney M. K., Fox J. P., Kenny G. E. 1982; Antigenic groupings of 90 rhinovirus serotypes. Infection and Immunity 37:642–647
    [Google Scholar]
  8. Doggett J. E. 1965; Prevention of colds by vaccination against a rhinovirus: a report by the scientific committee on common cold vaccines. British Medical Journal i:1344–1349
    [Google Scholar]
  9. Francis M. J., Clarke B. E. 1989; Peptide vaccines based on enhanced immunogenicity of peptide epitopes presented with T-cell determinants on hepatitis B core protein. Methods in Enzymology 178:659–675
    [Google Scholar]
  10. Francis M. J., Hastings G. Z., Sangar D. V., Clark R. P., Syred A., Clarke B. E., Rowlands D. J., Brown F. 1987; A synthetic peptide which elicits neutralizing antibody against human rhinovirus type 2. Journal of General Virology 68:2687–2691
    [Google Scholar]
  11. Francis M. J., Hastings G. Z., Campbell R. O., Peat N., Rowlands D. J., Brown F. 1989; T-cell help for B-cell antibody production to rhinovirus peptides. In Vaccines’89: Modern Approaches to New Vaccines Including Prevention of AIDS pp 437–444 Edited by Lerner R. A., Ginsberg H., Chanock R. M., Brown F. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  12. Greve J. M., Davis G., Meyer A. M., Forte C. P., Yost S. C., Marlor C. W., McClelland A. 1989; The major human rhinovirus receptor is ICAM-I. Cell 56:839–847
    [Google Scholar]
  13. Gwaltney J. M. Jr 1975; Medical reviews: rhinoviruses. Yale Journal of Biological Medicine 48:17–15
    [Google Scholar]
  14. Hamparian V. V., Colonno R. J., Cooney M. K., Dick E. C., Gwaltney J. M. Jr, Hughes J. H., Jordan W. S., Kapikian A. Z., Mogabgab W. J., Monto A., Phillips C. A., Rueckert R. R., Schieble J. H., Stott E. J., Tyrrell D. A. J. 1987; A collaborative report: rhinoviruses – extension of the numbering system from 89 to 100. Virology 159:191–192
    [Google Scholar]
  15. Hastings G. Z., Speller S. A., Francis M. J. 1990; Neutralizing antibodies to human rhinovirus produced in laboratory animals and humans that recognize a linear sequence from VP2. Journal of General Virology 71:3055–3059
    [Google Scholar]
  16. Hsia J., Goldstein A. L., Simon G. L., Sztein M., Hayden F. G. 1990; Peripheral blood mononuclear cell interleukin-2 and interferon production, cytotoxicity, and antigen-stimulated blastogenesis during experimental rhinovirus infection. Journal of Infectious Diseases 162:591–597
    [Google Scholar]
  17. Katrak K., Mahon B. P., Minor P. D., Mills K. H. G. 1991; Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus. Journal of General Virology 72:1093–1098
    [Google Scholar]
  18. Kim S., Smith T. J., Chapman M. S., Rossmann M. G., Pevear D. C., Dutko F. J., Felock P. J., Diana G. D., McKinlay M. A. 1989; The crystal structure of human rhinovirus serotype 1A (HRV1A). Journal of Molecular Biology 210:91–111
    [Google Scholar]
  19. Leclerc C., Deriaud E., Minic V., Van Der Werf S. 1991; Identification of a T-cell epitope adjacent to neutralization antigenic site 1 of poliovirus type 1. Journal of Virology 65:711–718
    [Google Scholar]
  20. Levandowski R. A., Ou D. W., Jackson G. G. 1986; Acute phase decrease of T lymphocyte subsets in rhinovirus infection. Journal of Infectious Diseases 153:743–748
    [Google Scholar]
  21. Mendappa K. C., McLean C., Rueckert R. R. 1971; On the structure of rhinovirus 1A. Virology 44:259–270
    [Google Scholar]
  22. Mishak H., Neubauer C., Kuechler E., Blaas D. 1988; Characteristics of the minor group receptor of human rhinoviruses. Virology 163:19–25
    [Google Scholar]
  23. Palmenberg A. C. 1989; Sequence alignment of picornaviral capsid proteins. In Molecular Aspects of Picornavirus Infection and Detection pp 211–241 Edited by Semler B. L., Ehrenfeld E. Washington, D.C.: American Society for Microbiology;
    [Google Scholar]
  24. Rothbard J. B. 1986; Peptides and their cellular immune response. Annals of the Institut Pasteur 137E:518–526
    [Google Scholar]
  25. Rueckert R. R. 1976; On the structure and morphogenesis of picornaviruses. In Comprehensive Virology vol 6 pp 131–213 Edited by Fraenkel-Conrat H., Wagner R. R. New York: Plenum Press;
    [Google Scholar]
  26. Skern T., Sommergruber W., Blaas D., Gruendler P., Fraundorfer F., Pieler C., Fogy I., Kuechler E. 1985; Human rhinovirus 2: complete nucleotide sequence and proteolytic processing signals in the capsid protein region. Nucleic Acids Research 13:2111–2126
    [Google Scholar]
  27. Staunton D. E., Meluzzi V. J., Rothlein R., Barton R., Marlin S. D., Springer T. A. 1989; A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Cell 56:849–853
    [Google Scholar]
  28. Stott E. J., Killington R. A. 1972; Rhinoviruses. Annual Review of Microbiology 26:503–524
    [Google Scholar]
  29. Uncapher C. R., Dewitt C. M., Colonno R. J. 1991; The major and minor group receptor families contain all but one human rhinovirus serotype. Virology 180:814–817
    [Google Scholar]
  30. Wang K., Sun L., Jabelt B., Waltenbaugh C. 1989; Cell-mediated immune responses to poliovirus. I. Conditions for induction, characterization of effector cells, and cross reactivity between serotypes for delayed hypersensitivity and T-cell proliferative responses. Cellular Immunology 119:252–262
    [Google Scholar]
  31. Yin F. H., Lomax N. B. 1983; Host range mutants of human rhinovirus in which nonstructural proteins are altered. Journal of Virology 48:410–418
    [Google Scholar]
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